Category: 73963-42-5

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, molecular formula is C11H19ClN4, belongs to pyridazines compound, is a common compound. In a patnet, author is Becker, Christian, once mentioned the new application about 73963-42-5, HPLC of Formula: C11H19ClN4.

Determination of liquid chromatography/flame ionization detection response factors for N-heterocycles, carboxylic acids, halogenated compounds, and others

Many gas chromatography-flame ionization detection (GC/FID) studies are dealing with response behavior of analytes such as alcohols and alkanes. Studies in the field of liquid chromatography (LC)/FID mainly focused on volatile analytes. In contrast, studies on LC/FID by conveyor type interface covered high molecular weight non-volatile biopolymers, whereby no response factors were calculated. With this study, we fill the gap and present response factors of volatile and non-volatile analytes by LC/FID in terms of flow injection (FIA) measurements of the single compounds without an analytical separation by an LC column. In the present study, 56 different compounds such as carboxylic acids, N-heterocycles, halogenated acids, pharmaceuticals, and other compounds were investigated. In some cases, the obtained response factor data confirmed aspects known from GC/FID studies. But this study also disproves several assumptions done in previous response studies as well as the prediction models based upon the experimental data and literature. Especially the response factors and effective carbon number (ECN) values of structural isomers such as pyrazine, pyridazine, and pyrimidine are assumed to be equal in current response prediction models. Contradictory to these assumptions, the experimental response factors and ECN values of, e.g., the structural isomers pyrazine (RFExp = 0.59; ECNExp = 3.66), pyridazine (RFExp = 0.66; ECNExp = 4.1), and pyrimidine (RFExp = 0.63; ECNExp = 3.93) reveal different experimental response factors and ECN than proposed by response factor prediction models (RFExp = 0.64; ECNExp = 4). Graphical abstract

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 73963-42-5. The above is the message from the blog manager. HPLC of Formula: C11H19ClN4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a document, author is Bhatt, Ashish, introduce the new discover, Product Details of 73963-42-5.

Facile one-pot synthesis of N-fused 1,2,4-triazoles via oxidative cyclization using manganese dioxide

A facile one-pot synthesis of N-fused 1,2,4-triazoles from heterocyclic hydrazines and aldehydes is reported. The reaction is efficiently promoted by manganese dioxide to afford the desired products mostly in high yields and in relatively short times. The mild nature of the synthesis, cheap oxidizing agent, and short reaction time are notable advantages of the developed protocol. This protocol is effective toward various substrates having different functionalities.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 73963-42-5 is helpful to your research. Product Details of 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 73963-42-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a article, author is Lv, Lina, introduce new discover of the category.

A structural and thermodynamic study of the complexes of U(vi) with azinecarboxylates

Complexation of U(vi) with pyridazine-3-carboxylate (PDZ) and pyrazine-2-carboxylate (PAZ) was studied by spectrophotometry, potentiometry and microcalorimetry in 1.0 mol dm(-3) NaClO4. Three complexes, [UO2L](+), UO2L2(aq) and [UO2L3](-), were identified and their stability constants (log) and the corresponding formation enthalpies were determined. The thermodynamic parameters indicate that the formation of the three complexes is endothermic and driven exclusively by entropy. H-1 and C-13-NMR data provide insight into the coordination modes of the complexes which corroborate with the thermodynamic data. Ligands chelate to U(vi) via (2)(N,O) coordination mode in complexes [UO2L](+) and UO2L2(aq). The crystal structures of four U(vi) complexes, [(UO2)(PAZ)(2)(H2O)]H2O(i), [(UO2)(PDZ)(2)(H2O)](ii), [(UO2)(PDZ)(3)Na2ClO4]2H(2)O(iii), and [(UO2)(2)(PDZ)(4)(H2O)(2)]2H(2)O(iv), were determined by single-crystal X-ray diffraction and compared with the U(vi) complex with picolinate (PA) (CH6N3)[UO2(PA)(3)] in the literature. The structure data suggest that the carboxylates coordinate with uranium in O?C-O-U mode. The strengths of the U-O-C-C-N chelate cycles in the U(vi)/L complexes decrease with the trend of PA > PDZ > PAZ, which is in great agreement with the trend of thermodynamic parameters in aqueous solutions. It is interesting that in compound II two PDZ molecules coordinate with U(vi) in cis-planar positions via (2)(N,O) mode, but in other metal complexes of the three ligands having the same (2)(N,O) coordination mode the two ligand molecules are all in trans-arrangement. In the dimeric complex IV, one ligand coordinate with U(vi) in (2)(N,O) mode, while the other does it in (2)-L-(2)(O:O) mode respectively.

Reference of 73963-42-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is an experimental science, Name: 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, molecular formula is C11H19ClN4, belongs to pyridazines compound. In a document, author is Olejniczak, Anna.

Short N center dot center dot center dot N and CH center dot center dot center dot N Contacts in the Ambient and High-Pressure Polymorphs of a High-Nitrogen-Content Compound

The compression of high-nitrogen-content compound 6-azido-1,2,3,4-tetrazolo[1,5-b]pyridazine, (C4H2N8), was studied in situ in a diamond-anvil cell by single-crystal X-ray diffraction. The compression of ambient-pressure phase alpha is monotonic to 2.5 GPa at least, and high-pressure isochoric recrystallizations yield phase alpha, too. A new polymorph beta could also be recrystallized from the low-concentration acetone solution, at high pressure below 0.5 GPa and temperature lower than 320 K. However, above 0.5 GPa again only the ambient-pressure form alpha was obtained. Both polymorphs are built of the azide-tetrazole tautomer, and intermolecular CH center dot center dot center dot N and N center dot center dot center dot N interactions are similar, but the molecules aggregate into planar sheets in phase alpha and into a three-dimensional network in phase beta. Polymorph beta can be stored for a few years in an open vial in ambient conditions with no signs of changes.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 73963-42-5. Name: 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, molecular formula is C11H19ClN4, belongs to pyridazines compound, is a common compound. In a patnet, author is Ewida, Menna A., once mentioned the new application about 73963-42-5, Application In Synthesis of 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole.

Thiazolo[4,5-d]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study

A new series of 1,3-thiazoles and thiazolo[4,5-d] pyridazine both bearing the 2-thioureido function were designed, synthesized and evaluated for their in vitro DHFR inhibition and antitumor activities. Compound 26 proved to be the most active DHFR inhibitor (IC50 of 0.06 mu M). Compound 4, 20 and 21 showed in vitro antitumor activity against a collection of cancer cell lines. Compound 26 proved lethal to HS 578T breast cancer cell line with IC50 value of 0.8 mu M, inducing cell cycle arrest and apoptosis. Molecular modeling studies concluded that recognition with key amino acids Phe 31 and Arg 22 is essential for DHFR binding. The obtained model could be useful for the development of new class of DHFR inhibitors. (C) 2017 Elsevier Inc. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 73963-42-5. The above is the message from the blog manager. Application In Synthesis of 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, in an article , author is Marino, Nadia, once mentioned of 73963-42-5, Application In Synthesis of 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole.

Magneto-structural correlations in Ni(ii) [2 x 2] metallogrids featuring a variable number of -aquo or -hydroxo extra bridges

Four new [2 x 2] grid-type metallosupramolecular species have been obtained by using the ditopic 3,6-bis(2-pyridyl)pyridazine ligand (dppn) and nickel(ii) salts containing poorly coordinating anions. Three of them have the formula [Ni-4(-dppn)(4)(-OH)(2)(-H2O)(2)]X-6 center dot nH(2)O [with X = ClO4- (1), NO3- (2) and CF3SO3- (3), and n = 6.5 (1), 14 (2) and 4 (3)]. Their crystal structure shows the same tetranuclear core, constituted by four six-coordinate metal ions and four dppn molecules. Two hydroxo groups and two water molecules efficiently interact forming two hydrated hydroxide (H3O2-) supramolecular bridging anions, further stabilizing the grid. The other compound, [Ni-4(-dppn)(4)(-OH)(3)(-H2O)](ClO4)(5)5H(2)O2EtOH (4), also exhibits the same tetranuclear core but with three hydroxo groups and one water molecule as supporting bridges, thus featuring only one hydrated hydroxide ion. Cryomagnetic measurements on polycrystalline samples of 1-4 in the temperature range 1.9-300 K reveal an overall antiferromagnetic behaviour. The values of the intramolecular magnetic coupling (J) cover the range -50.4(3) to -63.6(4) cm(-1), the Hamiltonian being defined as H = -J(S1S2 + S2S3 + S3S4 + S1S4) + gH(S-1 + S-2 + S-3 + S-4). The magneto-structural data of 1-4 show that the larger the average value at the hydroxo/aquo bridges is, the greater the antiferromagnetic coupling.

Interested yet? Read on for other articles about 73963-42-5, you can contact me at any time and look forward to more communication. Application In Synthesis of 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, molecular formula is C11H19ClN4, belongs to pyridazines compound. In a document, author is Chaudhry, Faryal, introduce the new discover, Quality Control of 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole.

Green synthesis, inhibition studies of yeast alpha-glucosidase and molecular docking of pyrazolylpyridazine amines

An efficient and environmentally benign simple fusion reaction of 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1 yl) pyridazine (1a) or 3-chloro-6-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl) pyridazine (2a) with different aliphatic/aromatic amines have produced a series of novel pyrazolylpyridazine amines (4a-4c & 5a-5m). All compounds exhibited moderate in vitro yeast alpha-glucosidase inhibition except m-chloro derivative 5g, which was found potent inhibitor of this enzyme with IC50 value of 19.27 +/- 0.005 mu M. The molecular docking further helped in understanding the structure activity relationship of these compounds including 5g. (C) 2017 Elsevier Inc. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 73963-42-5. Quality Control of 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, molecular formula is , belongs to pyridazines compound. In a document, author is Adiloglu, Yadigar, Product Details of 73963-42-5.

Cycloaddition Reactions of Benzonorbornadiene and Homonorbornadiene: New Isoxazoline and Pyridazine Derivatives

Ten new isoxazoline derivatives were synthesized from the reactions of benzonorbornadiene and homonorbornadiene derivatives with nitrile oxides formed from benzaldehyde and 4-substituted benzaldehyde. Two new pyridazine derivatives were also synthesized from the reaction of the homonorbornadiene derivatives with 3,6-di (2-pyridyl)-s-tetrazine. It was seen that all cycloaddition reactions were realized as exo selectivity. Finally, -Gauche effect in the isoxazoline derivatives was discussed.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 73963-42-5, in my other articles. Product Details of 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, molecular formula is , belongs to pyridazines compound. In a document, author is Obruchnikova, N. V., SDS of cas: 73963-42-5.

Synthesis and structural investigation of 4,4-dimethyl-[3,3-bi(1,2,5-oxadiazole)] 5,5-dioxide

The oxidation of hexane-2,3,4,5-tetraone tetraoxime with dinitrogen tetroxide was studied in different solvents. The primary furoxan ring closure was found to occur involving either two central or two terminal oxime groups to form 4,7-dimethyl[1,2,5]oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide and the previously unknown 4,4-dimethyl-[3,3-bi(1,2,5-oxadiazole)] 5,5-dioxide. The structure of the latter compound was established by X-ray diffraction.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 73963-42-5, 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, in an article , author is Poormirzaei, Nazanin, once mentioned of 73963-42-5.

Synthesis and characterization of a novel supported N-piperidine sulfamic acid on magnetic nanoparticles as a nanocatalyst for synthesis of pyrimido[4,5-c]pyridazines derivatives under ambient conditions and theoretical study on the mechanism using a DFT method

In this study, magnetic nanoparticles (Fe3O4 NPs) were employed as good support for N-piperidine sulfamic acid to prepare a novel nanocatalyst (SA-PPCA-Fe3O4 NPs). This nanocatalyst was then characterized by different techniques such as FT-IR, XRD, TGA, SEM, TEM and VSM. The catalytic activity of the SA-PPCA-Fe3O4 NPs was studied by one-pot preparation of pyrimido[4,5-c]pyridazines derivatives from three-component reactions of 1,3-dimethylthiobarbituric acid or 1,3-diethylthiobarbituric acid with different arylglyoxals and hydrazine monohydrate at ambient conditions. SA-PPCA-Fe3O4 NPs exhibited excellent advantages such as simplicity, high yields, short reaction time, easily separation using an external magnet, bio eco-friendly and recoverability and reusability with no remarkable loss of catalytic efficiency. In this work, density functional theory and modeling were reported to investigate of mechanism of the reaction. In fact, this study gives an insight into the mechanism of the pyrimido[4,5-c]pyridazines reaction in the presence of nanocatalyst of SA-PPCA-Fe3O4 NPs. Graphic abstract

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 73963-42-5, you can contact me at any time and look forward to more communication. Recommanded Product: 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem