Category: 70952-62-4

70952-62-4, 3,6-Dichloro-4-methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a mixed solvent of 1,4-dioxane (2.5 mL) and dimethylsulfoxide (2.5 mL) was dissolved 190 mg (1.16 mmol) of 2-cyclopropyl-3-methoxyphenol, 146 mg (1.30 mmol) of potassium tert-butoxide was added to the solution and the resulting mixture was stirred for 10 minutes. To the mixture was added 170 mg (0.950 mmol) of 3,6-dichloro-4-methoxypyridazine and the resulting mixture was stirred overnight. The reaction mixture was poured into ice water and extracted with ethyl acetate. The organic layers were combined, washed successively with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed, and the obtained residue was purified by silica gel chromatography (Wakogel C-100, hexane-ethyl acetate, gradient) to obtain 90.1 mg (0.293 mmol, Yield: 30.8%) of 6-chloro-3-(2-cycloprcpyl-3-methoxyphenoxy)-4-methoxypyridazine and 114 mg (0.371 mmol, Yield: 39.1%) of 3-chloro-6-(2-cyclopropyl-3-methoxyphenoxy)-4-methoxypyridazine., 70952-62-4

As the paragraph descriping shows that 70952-62-4 is playing an increasingly important role.

Reference£º
Patent; Sankyo Agro Company, Limited; EP1426365; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

70952-62-4, 3,6-Dichloro-4-methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,70952-62-4

In a mixed solvent of 1,4-dioxane (2 mL) and dimethylsulfoxide (2 mL) was dissolved 150 mg (0.670 mmol) of 2-[1-(ethylsulfanyl)ethyl]-3,5,6-trimethylphenol obtained in Example 633(5), 93 mg (0.83 mmol) of potassium tert-butoxide was added to the solution in an ice bath, and the resulting mixture was stirred at room temperature for 20 minutes. The mixture was again cooled in an ice bath, 120 mg (0.670 mmol) of 3,6-dichloro-4-methoxypyridazine was added to the mixture, and the resulting mixture was stirred at room temperature overnight. The reaction mixture was poured into water, and extracted with ethyl acetate. The organic layers were combined, washed successively with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed, and the obtained residue was purified by silica gel chromatography (Wakogel C-100, hexane-ethyl acetate, gradient) and by preparative thin-layer chromatography (available from MERCK CO., 1.05744, 2 plates were used, developed by hexane:ethyl acetate=2:1) to obtain 26.7 mg (0.0728 mmol, Yield: 10.9%) of 6-chloro-3-{2-[1-(ethylsulfanyl)ethyl]-3,5,6-trimethylphenoxy}-4-methoxypyridazine. Also, 60.0 mg (0.163 mmol, Yield: 24.3%) of 3-chloro-6-{2-[1-(ethylsulfanyl)ethyl]-3,5,6-trimethylphenoxy}-4-methoxypyridazine was obtained.

70952-62-4 3,6-Dichloro-4-methoxypyridazine 6401343, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Sankyo Agro Company, Limited; EP1426365; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

70952-62-4, 3,6-Dichloro-4-methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Description 1; 4-(6-Chloro-4-methoxy-pyridazin-3-ylamino)-piperidine-l-carboxylic acid tert- butyl ester (Dl); To a stirred solution of 3,6-dichloro-4-methoxy-pyridazine (0.73 g, 4.08mmol) (prepared by a procedure similar to that described in Eichenberger, K.; Rometsch, R..; Druey, J. Australian Journal of Chemistry 1956, 9, 1755-1764), 4-amino-piperidine-l- carboxylic acid tert-bvXy ester (0.98 g, 4.90 mmol) and cesium carbonate (2.66 g, 8.16 mmol) in toluene (15 ml) in a sealed tube under nitrogen, were added (R)-(+)-2,T- bis(diphenylphosphino)-l,r-binaphthyl (0.38 g, 0.61 mmol) and palladium(II) acetate (0.046 g, 0.20 mmol). The reactiom mixture was stirred at 110 C for 18 h.. After cooling to room temperature, the reaction mixture was filtered though Celite and the filtrate was evaporated. The crude product was purified by flash column chromatography (silica gel; 3 % ammonia in methanol (7M) / dichloromethane). The desired fractions were collected and evaporated in vacuo, to yield Dl (0.44 g, 32 %) as a yellow solid. Ci5H23ClN4O3 requires 342; Found 343 (MH+).

70952-62-4, The synthetic route of 70952-62-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/128995; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem