Category: 66346-87-0

66346-87-0, Name is 6-Chloro-5-methylpyridazin-3-amine, belongs to pyridazine compound, is a common compound. name: 6-Chloro-5-methylpyridazin-3-amineIn an article, once mentioned the new application about 66346-87-0.

SMA is an inherited disease that leads to loss of motor function and ambulation and a reduced life expectancy. We have been working to develop orally administrated, systemically distributed small molecules to increase levels of functional SMN protein. Compound 2 was the first SMN2 splicing modifier tested in clinical trials in healthy volunteers and SMA patients. It was safe and well tolerated and increased SMN protein levels up to 2-fold in patients. Nevertheless, its development was stopped as a precautionary measure because retinal toxicity was observed in cynomolgus monkeys after chronic daily oral dosing (39 weeks) at exposures in excess of those investigated in patients. Herein, we describe the discovery of 1 (risdiplam, RG7916, RO7034067) that focused on thorough pharmacology, DMPK and safety characterization and optimization. This compound is undergoing pivotal clinical trials and is a promising medicine for the treatment of patients in all ages and stages with SMA.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1101 – PubChem

 

Related Products of 66346-87-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.66346-87-0, Name is 6-Chloro-5-methylpyridazin-3-amine, molecular formula is C5H6ClN3. In a article，once mentioned of 66346-87-0

Imidazo[1,2-b]pyridazine-based compounds of the formula (I): are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 66346-87-0

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1071 – PubChem

 

Electric Literature of 66346-87-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.66346-87-0, Name is 6-Chloro-5-methylpyridazin-3-amine, molecular formula is C5H6ClN3. In a Patent，once mentioned of 66346-87-0

The invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R7, A, Y and L are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1072 – PubChem

 

Application of 66346-87-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.66346-87-0, Name is 6-Chloro-5-methylpyridazin-3-amine, molecular formula is C5H6ClN3. In a Patent，once mentioned of 66346-87-0

IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS

There is provided compounds of formula (I): wherein Z, M, R1, X, R3, R4 and R5 have meanings given in the description, an pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, an particularly in the treatment of cancer

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 66346-87-0

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1087 – PubChem

 

Synthetic Route of 66346-87-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.66346-87-0, Name is 6-Chloro-5-methylpyridazin-3-amine, molecular formula is C5H6ClN3. In a article，once mentioned of 66346-87-0

ALZHEIMER’S DISEASE IMAGING AGENTS

This invention provides compounds and methods of imaging amyloid deposits using radiolabeled compounds. This invention also provides a method of inhibiting the aggregation of amyloid proteins to form amyloid plaques or deposits, a method of determining a therapeutic compound’s ability to inhibit aggregation of amyloid protein, and a method of delivering a therapeutic agent to amyloid deposits.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 66346-87-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1080 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 66346-87-0, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 66346-87-0, Name is 6-Chloro-5-methylpyridazin-3-amine, molecular formula is C5H6ClN3

IMIDAZO [1,2-B] PYRIDAZINE AND IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AS JAK INHIBITORS

New imidazo[1,2-b]pyridazine and imidazo[4,5-b]pyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1079 – PubChem

 

Electric Literature of 66346-87-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 66346-87-0, Name is 6-Chloro-5-methylpyridazin-3-amine, molecular formula is C5H6ClN3. In a Patent，once mentioned of 66346-87-0

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 66346-87-0. In my other articles, you can also check out more blogs about 66346-87-0

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1089 – PubChem

 

Application of 66346-87-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 66346-87-0, Name is 6-Chloro-5-methylpyridazin-3-amine,introducing its new discovery.

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compotmds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1075 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: pyridazine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 66346-87-0, name is 6-Chloro-5-methylpyridazin-3-amine. In an article£¬Which mentioned a new discovery about 66346-87-0

2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF

The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy-C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl>C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, ?NR4R5, hydroxyl or C1-4 alkyloxy groups; A is a C1-7-alkylene group optionally substituted by one or two Ra groups; B is a C1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1-6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-allyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1078 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 6-Chloro-5-methylpyridazin-3-amine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 66346-87-0, Name is 6-Chloro-5-methylpyridazin-3-amine, molecular formula is C5H6ClN3

Imidazo<1,2-b>pyridazines. I Some 3-Alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl)inidazo<1,2-b>pyridazines and 3-Methoxy-2,6-diphenylimidazo<1,2-b>pyridazine

A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl)imidazo<1,2-b>pyridazines (1) and 3-methoxy-2,6-diphenylimidazo<1,2-b>pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O-alkylation of the corresponding imidazo<1,2-b>pyridazin-3(5H-ones with diazoalkanes. 6-Chloro-3-methoxy-2-phenylimidazo<2,1-a>phthalazine was prepared similarly.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 6-Chloro-5-methylpyridazin-3-amine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 66346-87-0, in my other articles.

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1097 – PubChem