Related Products of 66346-83-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.66346-83-6, Name is 6-Chloropyridazine-3-carboxamide, molecular formula is C5H4ClN3O. In a article£¬once mentioned of 66346-83-6
SYNTHESIS OF 6-ALKYLAMINO-3-PYRIDAZINECARBOXYLIC ACID DERIVATIVES FROM METHYL 6-CHLORO-3-PYRIDAZINECARBOXYLATE
The synthesis of methyl 6-alkylamino-3-pyridazinecarboxylates (4a-c) was accomplished by the following reaction sequence.On treatment of methyl 6-chloro-3-pyridazinecarboxylate (1) with methanolic ammonia, 6-chloro-3-pyridazinecarboxamide (5) was precipitated almost quantitatively, which reacted with primary alkylamines to give the corresponding 6-alkylamino-3-pyridazinecarboxamide (6a-c).These products were smoothly converted into the methyl esters (4a-c) by treatment with methanol in the presence of boron trifluoride etherate.The reaction of 1 with butylamine in THF ga ve a complicated mixture in which N-butyl-6-chloro-3-pyridazinecarboxamide (2), N-butyl-6-butylamino-3-pyridazinecarboxamide (3), 4b, and 1 were involved.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 66346-83-6
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2024 – PubChem