Category: 65632-62-4

65632-62-4, (S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,65632-62-4

a) Esterification of the Acid Function; The hexahydropyridazinic acid (40 g; 0.151 mol) is dissolved in 200 ml of methanol and cooled to 0 C. SOCl2 (36 ml; 0.45 mol) is added dropwise. The solution becomes clear; the temperature is allowed to return very gradually to ambient temperature and the solution is then refluxed for one hour. The mixture is poured onto a DCM(200 ml)/ice(500 g)/NaHCO3(60 g) mixture. The aqueous phase is extracted with DCM. The organic phase is washed with a saturated NaHCO3 solution and then dried over MgSO4. A colorless oil (41 g; 99%) is obtained and is used as it is.

As the paragraph descriping shows that 65632-62-4 is playing an increasingly important role.

Reference：
Patent; Aventis Pharma S.A.; US2005/171346; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

65632-62-4,65632-62-4, (S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: Preparation of l-(phenylmethyl) hydrogen tetrahydro-2-nitrosopyridazine-1 ,(35)(2H)-dicarboxylateA solution of sodium nitrite (1.03 g, 15.0 mmol) in 8 rnL of water was added dropwise over 10 minutes to a suspension of l-(phenylmethyl) hydrogen tetrahydropyridazine-l,(35)(2H)-dicarboxylate (2.64 g, 10.0 mmol; prepared as described inCoats et al. J. Org. Chem. 2004, 69, 1734) in 1 N hydrochloric acid (30 mL) at 4 0C. After3.5 h the reaction mixture was diluted with ethyl acetate (40 mL), and the layers were separated. The aqueous layer was extracted with ethyl acetate (2 X 20 mL), and the combined organic layers were dried over sodium sulfate, filtered and concentrated under reduced pressure to give 3.14 g of the title compound as a yellow oil. This compound was carried on without further purification or characterization.

The synthetic route of 65632-62-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; E.I. DU PONT DE NEMOURS AND COMPANY; WO2009/76440; (2009); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

65632-62-4, (S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,65632-62-4

a) Esterification of the Acid Function; The hexahydropyridazinic acid (40 g; 0.151 mol) is dissolved in 200 ml of methanol and cooled to 0 C. SOCl2 (36 ml; 0.45 mol) is added dropwise. The solution becomes clear; the temperature is allowed to return very gradually to ambient temperature and the solution is then refluxed for one hour. The mixture is poured onto a DCM(200 ml)/ice(500 g)/NaHCO3(60 g) mixture. The aqueous phase is extracted with DCM. The organic phase is washed with a saturated NaHCO3 solution and then dried over MgSO4. A colorless oil (41 g; 99%) is obtained and is used as it is.

As the paragraph descriping shows that 65632-62-4 is playing an increasingly important role.

Reference：
Patent; Aventis Pharma S.A.; US2005/171346; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65632-62-4,(S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.,65632-62-4

The hexahydropyridazinic acid (40 g; 0.151 mol) is dissolved in 200 ml of methanol and cooled to 0 C. SOCl2 (36 ml; 0.45 mol) is added dropwise. The solution becomes clear; the temperature is allowed to return very gradually to ambient temperature, and the solution is then refluxed for one hour. The mixture is poured onto a DCM(200 ml)/ice(500 g) /NaHCO3(60 g) mixture. The aqueous phase is extracted with DCM. The organic phase is washed with a saturated NaHCO3 solution and then dried over MgSO4. A colorless oil is obtained (41 g; 99%) and is used as it is.

65632-62-4 (S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid 11129166, apyridazine compound, is more and more widely used in various fields.

Reference：
Patent; Aventis Pharma S.A.; US2005/215553; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

65632-62-4,65632-62-4, (S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: Preparation of l-(phenylmethyl) hydrogen tetrahydro-2-nitrosopyridazine-1 ,(35)(2H)-dicarboxylateA solution of sodium nitrite (1.03 g, 15.0 mmol) in 8 rnL of water was added dropwise over 10 minutes to a suspension of l-(phenylmethyl) hydrogen tetrahydropyridazine-l,(35)(2H)-dicarboxylate (2.64 g, 10.0 mmol; prepared as described inCoats et al. J. Org. Chem. 2004, 69, 1734) in 1 N hydrochloric acid (30 mL) at 4 0C. After3.5 h the reaction mixture was diluted with ethyl acetate (40 mL), and the layers were separated. The aqueous layer was extracted with ethyl acetate (2 X 20 mL), and the combined organic layers were dried over sodium sulfate, filtered and concentrated under reduced pressure to give 3.14 g of the title compound as a yellow oil. This compound was carried on without further purification or characterization.

The synthetic route of 65632-62-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; E.I. DU PONT DE NEMOURS AND COMPANY; WO2009/76440; (2009); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65632-62-4,(S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.,65632-62-4

The hexahydropyridazinic acid (40 g; 0.151 mol) is dissolved in 200 ml of methanol and cooled to 0 C. SOCl2 (36 ml; 0.45 mol) is added dropwise. The solution becomes clear; the temperature is allowed to return very gradually to ambient temperature, and the solution is then refluxed for one hour. The mixture is poured onto a DCM(200 ml)/ice(500 g) /NaHCO3(60 g) mixture. The aqueous phase is extracted with DCM. The organic phase is washed with a saturated NaHCO3 solution and then dried over MgSO4. A colorless oil is obtained (41 g; 99%) and is used as it is.

65632-62-4 (S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid 11129166, apyridazine compound, is more and more widely used in various fields.

Reference：
Patent; Aventis Pharma S.A.; US2005/215553; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

65632-62-4, (S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,65632-62-4

a) Esterification of the Acid Function; The hexahydropyridazinic acid (40 g; 0.151 mol) is dissolved in 200 ml of methanol and cooled to 0 C. SOCl2 (36 ml; 0.45 mol) is added dropwise. The solution becomes clear; the temperature is allowed to return very gradually to ambient temperature and the solution is then refluxed for one hour. The mixture is poured onto a DCM(200 ml)/ice(500 g)/NaHCO3(60 g) mixture. The aqueous phase is extracted with DCM. The organic phase is washed with a saturated NaHCO3 solution and then dried over MgSO4. A colorless oil (41 g; 99%) is obtained and is used as it is.

As the paragraph descriping shows that 65632-62-4 is playing an increasingly important role.

Reference：
Patent; Aventis Pharma S.A.; US2005/171346; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

65632-62-4,65632-62-4, (S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: Preparation of l-(phenylmethyl) hydrogen tetrahydro-2-nitrosopyridazine-1 ,(35)(2H)-dicarboxylateA solution of sodium nitrite (1.03 g, 15.0 mmol) in 8 rnL of water was added dropwise over 10 minutes to a suspension of l-(phenylmethyl) hydrogen tetrahydropyridazine-l,(35)(2H)-dicarboxylate (2.64 g, 10.0 mmol; prepared as described inCoats et al. J. Org. Chem. 2004, 69, 1734) in 1 N hydrochloric acid (30 mL) at 4 0C. After3.5 h the reaction mixture was diluted with ethyl acetate (40 mL), and the layers were separated. The aqueous layer was extracted with ethyl acetate (2 X 20 mL), and the combined organic layers were dried over sodium sulfate, filtered and concentrated under reduced pressure to give 3.14 g of the title compound as a yellow oil. This compound was carried on without further purification or characterization.

The synthetic route of 65632-62-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; E.I. DU PONT DE NEMOURS AND COMPANY; WO2009/76440; (2009); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65632-62-4,(S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.,65632-62-4

The hexahydropyridazinic acid (40 g; 0.151 mol) is dissolved in 200 ml of methanol and cooled to 0 C. SOCl2 (36 ml; 0.45 mol) is added dropwise. The solution becomes clear; the temperature is allowed to return very gradually to ambient temperature, and the solution is then refluxed for one hour. The mixture is poured onto a DCM(200 ml)/ice(500 g) /NaHCO3(60 g) mixture. The aqueous phase is extracted with DCM. The organic phase is washed with a saturated NaHCO3 solution and then dried over MgSO4. A colorless oil is obtained (41 g; 99%) and is used as it is.

65632-62-4 (S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid 11129166, apyridazine compound, is more and more widely used in various fields.

Reference：
Patent; Aventis Pharma S.A.; US2005/215553; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem