Category: 65202-52-0

Synthetic Route of C6H5BrN2O2In 2021, Heinrich, Timo;Sala-Hojman, Ada;Ferretti, Roberta;Petersson, Carl;Minguzzi, Stefano;Gondela, Andrzej;Ramaswamy, Shivapriya;Bartosik, Anna;Czauderna, Frank;Crowley, Lindsey;Wahra, Pamela;Schilke, Heike;Boepple, Pia;Dudek, Lukasz;Les, Marcin;Niedziejko, Paulina;Olech, Kamila;Pawlik, Henryk;Wloszczak, Lukasz;Zuchowicz, Karol;Suarez Alvarez, Jose Ramon;Martyka, Justyna;Sitek, Ewa;Mikulski, Maciej;Szczesniak, Joanna;Jaeckel, Sven;Krier, Mireille;Krol, Marcin;Wegener, Ansgar;Galezowski, Michal;Nowak, Mateusz;Becker, Frank;Herhaus, Christian published 《Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology》. 《Journal of Medicinal Chemistry》published the findings. The article contains the following contents:

Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporter that plays a central role in tumor pH modulation. The discovery and optimization of a novel class of MCT4 inhibitors (hit 9a), identified by a cellular screening in MDA-MB-231, is described. Direct target interaction of the optimized compound 18n with the cytosolic domain of MCT4 was shown after solubilization of the GFP-tagged transporter by fluorescence cross-correlation spectroscopy and microscopic studies. In vitro treatment with 18n resulted in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. Moreover, pharmacokinetic properties of 18n allowed assessment of lactate modulation and antitumor activity in a mouse tumor model. Thus, 18n represents a valuable tool for investigating selective MCT4 inhibition and its effect on tumor biol. And Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) was used in the research process.

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.Synthetic Route of C6H5BrN2O2 It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Related Products of 65202-52-0《Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors》 was published in 2016. The authors were Ohno, Hiroaki;Minamiguchi, Daiki;Nakamura, Shinya;Shu, Keito;Okazaki, Shiho;Honda, Maho;Misu, Ryosuke;Moriwaki, Hirotomo;Nakanishi, Shinsuke;Oishi, Shinya;Kinoshita, Takayoshi;Nakanishi, Isao;Fujii, Nobutaka, and the article was included in《Bioorganic & Medicinal Chemistry》. The author mentioned the following in the article:

Two classes of modified analogs of 4-(thiazol-5-yl)benzoic acid-type CK2 inhibitors were designed. The azabenzene analogs, pyridine- and pyridazine-carboxylic acid derivatives, showed potent protein kinase CK2 inhibitory activities [IC₅₀ (CK2α) = 0.014-0.017 μM; IC₅₀ (CK2α’) = 0.0046-0.010 μM]. Introduction of a 2-halo- or 2-methoxy-benzyloxy group at the 3-position of the benzoic acid moiety maintained the potent CK2 inhibitory activities [IC₅₀ (CK2α) = 0.014-0.016 μM; IC₅₀ (CK2α’) = 0.0088-0.014 μM] and led to antiproliferative activities [CC₅₀ (A549) = 1.5-3.3 μM] three to six times higher than those of the parent compound To complete the study, the researchers used Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) .

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.Related Products of 65202-52-0 It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Barlin, Gordon B.;Yap, C. Yoot published 《Some 3-halopyridazines》. The research results were published in《Australian Journal of Chemistry》 in 1977.COA of Formula: C6H5BrN2O2 The article conveys some information:

3-Halogenopyridazines including 3-fluoro-6-methyl- and 3-iodo-pyridazines; Me 3-fluoro-, 3-bromo- and 3-iodopyridazine-6-carboxylates and some intermediates were prepared Thus, Me 3-hydroxypyridazine-6-carboxylate was treated with POCl₃ to give Me 3-chloropyridazine-6-carboxylate. To complete the study, the researchers used Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) .

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.COA of Formula: C6H5BrN2O2 It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Recommanded Product: Methyl 6-bromopyridazine-3-carboxylateIn 2021, Heinrich, Timo;Sala-Hojman, Ada;Ferretti, Roberta;Petersson, Carl;Minguzzi, Stefano;Gondela, Andrzej;Ramaswamy, Shivapriya;Bartosik, Anna;Czauderna, Frank;Crowley, Lindsey;Wahra, Pamela;Schilke, Heike;Boepple, Pia;Dudek, Lukasz;Les, Marcin;Niedziejko, Paulina;Olech, Kamila;Pawlik, Henryk;Wloszczak, Lukasz;Zuchowicz, Karol;Suarez Alvarez, Jose Ramon;Martyka, Justyna;Sitek, Ewa;Mikulski, Maciej;Szczesniak, Joanna;Jaeckel, Sven;Krier, Mireille;Krol, Marcin;Wegener, Ansgar;Galezowski, Michal;Nowak, Mateusz;Becker, Frank;Herhaus, Christian published 《Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology》. 《Journal of Medicinal Chemistry》published the findings. The article contains the following contents:

Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporter that plays a central role in tumor pH modulation. The discovery and optimization of a novel class of MCT4 inhibitors (hit 9a), identified by a cellular screening in MDA-MB-231, is described. Direct target interaction of the optimized compound 18n with the cytosolic domain of MCT4 was shown after solubilization of the GFP-tagged transporter by fluorescence cross-correlation spectroscopy and microscopic studies. In vitro treatment with 18n resulted in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. Moreover, pharmacokinetic properties of 18n allowed assessment of lactate modulation and antitumor activity in a mouse tumor model. Thus, 18n represents a valuable tool for investigating selective MCT4 inhibition and its effect on tumor biol. And Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) was used in the research process.

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.Recommanded Product: Methyl 6-bromopyridazine-3-carboxylate It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

HPLC of Formula: 65202-52-0《Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors》 was published in 2016. The authors were Ohno, Hiroaki;Minamiguchi, Daiki;Nakamura, Shinya;Shu, Keito;Okazaki, Shiho;Honda, Maho;Misu, Ryosuke;Moriwaki, Hirotomo;Nakanishi, Shinsuke;Oishi, Shinya;Kinoshita, Takayoshi;Nakanishi, Isao;Fujii, Nobutaka, and the article was included in《Bioorganic & Medicinal Chemistry》. The author mentioned the following in the article:

Two classes of modified analogs of 4-(thiazol-5-yl)benzoic acid-type CK2 inhibitors were designed. The azabenzene analogs, pyridine- and pyridazine-carboxylic acid derivatives, showed potent protein kinase CK2 inhibitory activities [IC₅₀ (CK2α) = 0.014-0.017 μM; IC₅₀ (CK2α’) = 0.0046-0.010 μM]. Introduction of a 2-halo- or 2-methoxy-benzyloxy group at the 3-position of the benzoic acid moiety maintained the potent CK2 inhibitory activities [IC₅₀ (CK2α) = 0.014-0.016 μM; IC₅₀ (CK2α’) = 0.0088-0.014 μM] and led to antiproliferative activities [CC₅₀ (A549) = 1.5-3.3 μM] three to six times higher than those of the parent compound To complete the study, the researchers used Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) .

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.HPLC of Formula: 65202-52-0 It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Barlin, Gordon B.;Yap, C. Yoot published 《Some 3-halopyridazines》. The research results were published in《Australian Journal of Chemistry》 in 1977.Application In Synthesis of Methyl 6-bromopyridazine-3-carboxylate The article conveys some information:

3-Halogenopyridazines including 3-fluoro-6-methyl- and 3-iodo-pyridazines; Me 3-fluoro-, 3-bromo- and 3-iodopyridazine-6-carboxylates and some intermediates were prepared Thus, Me 3-hydroxypyridazine-6-carboxylate was treated with POCl₃ to give Me 3-chloropyridazine-6-carboxylate. To complete the study, the researchers used Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) .

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.Application In Synthesis of Methyl 6-bromopyridazine-3-carboxylate It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem