Category: 65202-50-8

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: pyridazine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 65202-50-8, name is Methyl 6-chloropyridazine-3-carboxylate. In an article£¬Which mentioned a new discovery about 65202-50-8

NEW COMPOUNDS

The present invention provides certain compounds according to formula (I) which are inhibitors of SSAO activity wherein V, W, X, Y, Z, R1 and R2 are as defined in the specification.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 65202-50-8, help many people in the next few years.category: pyridazine

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Pyridazine | C4H4N2410 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of Methyl 6-chloropyridazine-3-carboxylate, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 65202-50-8, name is Methyl 6-chloropyridazine-3-carboxylate. In an article£¬Which mentioned a new discovery about 65202-50-8

BICYCLIC COMPOUND

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 65202-50-8, help many people in the next few years.Safety of Methyl 6-chloropyridazine-3-carboxylate

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Pyridazine | C4H4N2430 – PubChem

 

65202-50-8, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 65202-50-8, name is Methyl 6-chloropyridazine-3-carboxylate, introducing its new discovery.

INHIBITORS OF JANUS KINASES

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.65202-50-8, you can also check out more blogs about65202-50-8

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2422 – PubChem

 

65202-50-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.65202-50-8, Name is Methyl 6-chloropyridazine-3-carboxylate, molecular formula is C6H5ClN2O2. In a Article, authors is Spanka, Carsten£¬once mentioned of 65202-50-8

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity

High throughput screening led to the identification of nicotinamide derivative 2 as a structurally novel mGluR5 antagonist. Optimization of the modular scaffold led to the discovery of 16m, a compound with high affinity for mGluR5 and excellent selectivity over other glutamate receptors. Compound 16m exhibits a favorable PK profile in rats, robust anxiolytic-like effects in three different animal models of fear and anxiety, as well as a good PK/PD correlation.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.65202-50-8. In my other articles, you can also check out more blogs about 65202-50-8

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2438 – PubChem

 

65202-50-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65202-50-8,Methyl 6-chloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.

Step 2; Methyl 6-(G-?)-3-r2-(trifluoromethyl)phenoxylpyrrolidin-l-vpipyridazine-3-carboxylate; A mixture of methyl 6-chloropyridazine-3-carboxylate (1.1 g, 6.4 mmol), (35)-3-[2- (trifluoromethyl)phenoxy]pyrrolidine (1.6 g, 6.9 mmol), potassium carbonate (1.8 g, 12.7 mmol) and tetrabutylammonium iodide (47 mg, 0.13 mmol) in dioxane (60 mL) was heated at 90-95 0C bath for 24 h. After cooling, the mixture was filtered through celite, washed with EtOAc and concentrated. The residue was re-dissolved in EtOAc, washed twice with water, dried and concentrated in vacuo, and swished with Et2O:hexane to give the title compound as a brown powder. EPO 1H NMR (500 MHz, acetone-d6): delta 7.88 (d, 1 H), 7.69-7.63 (m, 2 H), 7.43 (d, 1 H), 7.15 (t, 1 H), 6.96 (d, 1 H), 5.53 (s, 1 H), 4.00 (m, 3H), 3.90 (s, 3 H), 3.75 (m, 1 H), 2.54-2.44 (m, 2 H).

65202-50-8 Methyl 6-chloropyridazine-3-carboxylate 12379801, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/9236; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65202-50-8,Methyl 6-chloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.,65202-50-8

A solution of 6-chloro-pyridazine-3-carboxylic acid methyl ester in NaOMe in [MEOH] [(1M,] [10ML)] was refluxed on. [H20] was added and the mixture was extracted three times with DCM to give organic phase [I.] The combined organic phases I were dried and concentrated to give the title compound (40 mg, 10percent). The water phase was acidified with concentrated hydrochloric acid and extracted three times with DCM to give organic phase II. The combined organic phases II were dried and concentrated to give 6-methoxy-pyridazine-3-carboxylic acid (LC-MS [(M++1)] : 155) (230 mg, 65percent). A solution of 6-methoxy-pyridazine-3-carboxylic acid in thionyl chloride (6 ml) was refluxed for 3 h. The reaction was cooled to ambient temperature and evaporated to dryness. [MEOH] (10 ml) was added to the residue and the solution was stirred on at rt. Saturated [NAHC03] (aq) was added and the mixture was extracted three times with DCM. The combined organic phases were dried and concentrated to give the title compound (253 mg, 100percent). LC-MS [(M++1)] : 169.

The synthetic route of 65202-50-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,65202-50-8

To a suspension of methyl 6- chloropyridazine-3-carboxylate (1 g, 5.8 mmol) and imidazole (400 mg, 5.8 mmol) in dry DMF (10 mL), was added K2CO3 (950 mg, 6.8 mmol) and the reaction mixture was stirred at 120 C for 3h. The reaction was monitored by LCMS. After complete conversion to methyl 6- (1 H-imidazol-1-yl)pyridazine-3-carboxylate, 2.5 M aq. LiOH (2.8 mL, 6.96 mmol) was added to the reaction mixture and stirred at 60 C for 1 h. The reaction was monitored by LCMS. After completion of the reaction, the reaction mixture was acidified with aq.1 M HCI and the resulting precipitate was filtered and washed with water, to obtain the acid A (720 mg) as an off-white solid which was used in the next step without further purification. LC-MS (ESI+): m/z 191.0 [M+H]+.

As the paragraph descriping shows that 65202-50-8 is playing an increasingly important role.

Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; LAIRSON, Luke, L.; CHIN, Emily, N.; CHATTERJEE, Arnab; KUMAR, Manoj; ALBERO, Ana, Maria, Gamo; PETRASSI, Mike; SCHULTZ, Peter; YU, Chenguang; TAMIYA, Junko; VERNIER, William; GUPTA, Anil; MODUKURI, Ramkumar; (0 pag.)WO2019/165032; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65202-50-8,Methyl 6-chloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.,65202-50-8

:p 3: Methyl 6-(3- { [2-(trifluoromethyl)benzylloxyl azetidin- 1 -yl)pyridazine-3- carboxylate; A suspension of 3-{[2-(trifluoromethyl)benzyl]oxy}azetidine (595 mg, 2.58 mmol), methyl beta-chloropyridazine-S-carboxylate (450 mg, 2.58 mmol), potassium carbonate (715 mg, 5.15 mmol) and tetrabutylammonium iodide (20 mg, 0.052 mmol) in dioxane (10 mL) was heated to 95 ¡ãC for 16 h. The cooled reaction mixture was poured into a 125 mL separatory funnel containing water (50 mL) and extracted with ethyl acetate (3 x 30 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated. Purification by column chromatography through silica gel gave the title compound.1H NMR (J6-acetone, 400 MHz) delta 7.86-7.80 (2H, m), 7.75-7.51 (3H, m), 6.79 (IH, d, J= 9.5 Hz), 4.78-4.76 (3H, m), 4.49 (2H, dd, J= 10.0, 6.5 Hz), 4.15 (2H, dd, J= 10.0, 4.0 Hz), 3.88 (3H, s).MS (ESI, Q+) m/z 368 (M+ 1).

As the paragraph descriping shows that 65202-50-8 is playing an increasingly important role.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/143823; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,65202-50-8

Example 87 [0264] Formula 88] [0265] 1) In tetrahydrofuran (100 mL) was dissolved methyl 6-chloropyridazin-3-carboxylate (1.726 g), the solution was cooled to 0¡ãC, 1M diisobutyaluminum hydride-tetrahydro- furan solution (20 mL) was added dropwise to the solution, and the mixture was stirred at the same temperature for 20 minutes. To the reaction mixture were successively added water (10 mL) and IN hydrochloric acid (20 mL) at 0¡ãC. After adding a saturated aqueous sodium bicarbonate solution to the mixture at room temperature, the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and the residue obtained by concentrating the extract under reduced pressure was purified by silica gel column chromatography (n-hexane: ethyl acetate=90: 10 to 25:75) to obtain (6-chloropyridazin-3-yl)methanol (177 mg).MS (m/z): 147/145 [M+H]+

As the paragraph descriping shows that 65202-50-8 is playing an increasingly important role.

Reference£º
Patent; MITSUBISHI TANABE PHARMA CORPORATION; SAKURAI, Osamu; SARUTA, Kunio; HAYASHI, Norimitsu; GOI, Takashi; MOROKUMA, Kenji; TSUJISHIMA, Hidekazu; SAWAMOTO, Hiroaki; SHITAMA, Hiroaki; IMASHIRO, Ritsuo; WO2012/81736; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

65202-50-8, A solution of Example 65D (600mg, 3.48mmol), vinyl pinacol borate (803.2mg, 5.22mmol), potassium carbonate(961.07mg, 6.95mmol) and Pd(PPh3)4 (602.66mg, 521.53mmol) in DMF (8mL) was stirred at 100¡ãC for 5 hours undernitrogen atmosphere. The solution was cooled, filtered and concentrated in vacuo. The residue was purified by columnchromatography to give the title compound (500mg, yield 84.02percent). 1H NMR (400MHz, CHLOROFORM-d) ppm 8.18 (d,J=8.8 Hz, 1H), 7.72 (d, J=8.8 Hz, 1H), 7.16 (dd, J=11.0, 17.8 Hz, 1H), 6.44 (d, J=17.8 Hz, 1H), 5.85 (d, J=10.8 Hz, 1H),4.10 (s, 3H).

The synthetic route of 65202-50-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Harbin Zhenbao Pharmaceutical Co., Ltd.; Medshine Discovery Inc.; CHEN, Shuhui; CHEN, Zhengxia; DAI, Meibi; XIE, Cheng; LI, Peng; ZHANG, Yang; LIANG, Guibai; WANG, Qiang; LIAO, Jiangpeng; SUN, Fei; HU, Guoping; LI, Jian; (166 pag.)EP3333157; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem