Category: 64068-00-4

64068-00-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 64068-00-4, molecular formula is C5H6ClN3, introducing its new discovery.

2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF

The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy-C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl>C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, ?NR4R5, hydroxyl or C1-4 alkyloxy groups; A is a C1-7-alkylene group optionally substituted by one or two Ra groups; B is a C1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1-6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-allyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.64068-00-4, you can also check out more blogs about64068-00-4

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1042 – PubChem

 

64068-00-4, Name is 6-Chloro-4-methylpyridazin-3-amine, belongs to pyridazine compound, is a common compound. 64068-00-4In an article, authors is Barlin, Gordon B., once mentioned the new application about 64068-00-4.

Imidazo<1,2-b>pyridazines. I Some 3-Alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl)inidazo<1,2-b>pyridazines and 3-Methoxy-2,6-diphenylimidazo<1,2-b>pyridazine

A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl)imidazo<1,2-b>pyridazines (1) and 3-methoxy-2,6-diphenylimidazo<1,2-b>pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O-alkylation of the corresponding imidazo<1,2-b>pyridazin-3(5H-ones with diazoalkanes. 6-Chloro-3-methoxy-2-phenylimidazo<2,1-a>phthalazine was prepared similarly.

If you are interested in 64068-00-4, you can contact me at any time and look forward to more communication. 64068-00-4

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1058 – PubChem

 

64068-00-4, 6-Chloro-4-methylpyridazin-3-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

64068-00-4, 6-Chloro-4-methyl-pyridazin-3-amine (3.5 g, 24 mmol) was combined with ethanol (40 mL), triethylamine (8.7 mL, 62 mmol) and chloroacetone (4 mL, 49 mmol) in a 100 mL high pressure flask. The flask was sealed and heated behind a blast shield at 150 C for 45 min. The mixture was concentrated and chromatographed on silica gel, eluting with 30-80% EtOAc in CH2C12 to yield 6-chloro-2,8-dimethylimidazo[l,2-b]pyridazine (2.2 g, 49%). MS m/z 182.3, 184.3 [M+H]+.

The synthetic route of 64068-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PTC THERAPEUTICS, INC.; WOLL, Matthew, G.; AMEDZO, Lukiana; BABU, Suresh; BARRAZA, Scott, J.; BHATTACHARYYA, Anuradha; KARP, Gary, Mitchell; MAZZOTTI, Anthony, R.; NARASIMHAN, Jana; PATEL, Jigar; TURPOFF, Anthony; XU, Zhenrong; (251 pag.)WO2018/226622; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem