Category: 62567-44-6

Application of 62567-44-6On October 31, 2009 ,《Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines》 appeared in Tetrahedron. The author of the article were Donohoe, Timothy J.; Bower, John F.; Basutto, Jose A.; Fishlock, Lisa P.; Procopiou, Panayiotis A.; Callens, Cedric K. A.. The article conveys some information:

Ring-closing olefin metathesis (RCM) has been applied to the efficient synthesis of densely and diversely substituted pyridine and pyridazine frameworks. Routes to suitable metathesis precursors have been investigated and the scope of the metathesis step has been probed. The metathesis products function as precursors to the target heteroaromatic structures via elimination of a suitable leaving group, which also facilitates earlier steps by serving as a protecting group at nitrogen. Further functionalization of the metathesis products is possible both prior to and after aromatization. The net result is a powerful strategy for the de novo synthesis of highly substituted heteroaromatic scaffolds. In the experiment, the researchers used 3-Ethoxypyridazine(cas: 62567-44-6Application of 62567-44-6)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Application of 62567-44-6

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

《Product class 8: pyridazines》 was published in Science of Synthesis in 2004. These research results belong to Haider, N.; Holzer, W.. Category: pyridazine The article mentions the following:

A review. Methods of preparing pyridazines are reviewed including cyclization, ring transformation, aromatization, and substituent modification. The experimental process involved the reaction of 3-Ethoxypyridazine(cas: 62567-44-6Category: pyridazine)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Kim, Chang Kon; Lee, Bon Su; Lee, Ikchoon published an article on February 20 ,1992. The article was titled 《Determination of reactivity by MO theory. 78. Theoretical studies on the gas-phase pyrolysis of 2-alkoxypyrimidines, 2-alkoxypyrazines, 4-ethoxypyrimidine and 3-ethoxypyridazine》, and you may find the article in Bulletin of the Korean Chemical Society.Synthetic Route of C6H8N2O The information in the text is summarized as follows:

The gas-phase pyrolysis reactions of 2-alkoxypyrimidines (II), 2-alkoxypyrazines (III), 4-ethoxypyrimidine (IV) and 3-ethoxypyridazine (V) are investigated theor. using the AM1 MO method. These compounds pyrolyze in a concerted retro-ene process with a six-membered cyclic transition state (TS). The relative order of reactivity is (IV) > (II) > (III) > (V), which can be rationalized by the two effects arising from electron-withdrawing power of the aza-substituent: (i) electron withdrawal from the C-O bond accelerates the rate and (ii) electron withdrawal from the N1-atom, that is participating in the six-membered TS, deactivates the reaction. The exptl. result of the greatest reactivity for pyridazine, (V), cannot be explained with the AM1 results. The reactivity increase accompanied by successive methylation of the ethoxy group, ethoxy < iso-propoxy > tert-butoxy, is due to a release of steric crowding in the activation process. In the part of experimental materials, we found many familiar compounds, such as 3-Ethoxypyridazine(cas: 62567-44-6Synthetic Route of C6H8N2O)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Synthetic Route of C6H8N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The author of 《The structures of diazine N-oxides. II. Dipole moments of some alkoxy derivatives of pyrimidine, pyridazine, and their N-oxides》 were Otomasu, Hirotaka; Takahashi, Hiroshi; Ogata, Michihiko. And the article was published in Chemical & Pharmaceutical Bulletin in 1964. Formula: C6H8N2O The author mentioned the following in the article:

cf. CA 58, 5159e. The dipole moments of some diazines and their N-oxides was measured in C6H6 at 25°. [Compound and μ (D.) given]: 4-ethoxy-6-methylpyrimidine (I), 2.20; I N-oxide, 3.95; 3-methoxypyridazine (II), 2.87; II N-oxide (III), 4.80; 3-ethoxypyridazine (IV), (b14 91-3°), 3.17; IV N-oxide (V), (m. 65-7°), 4.76; 3-ethoxy-6-methylpyridazine (VI), 2.86; VI N-oxide, 5.11. The dipole moments were consistent with the moment of cis configuration. The conclusions of Hayashi, et al. (CA 58, 3425c) concerning the position of the N-oxide with respect to the alkoxyl group were confirmed. In the experimental materials used by the author, we found 3-Ethoxypyridazine(cas: 62567-44-6Formula: C6H8N2O)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Formula: C6H8N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In 1977,Chemical & Pharmaceutical Bulletin included an article by Hasegawa, Hiroshi; Arai, Heihachiro; Igeta, Hiroshi. Category: pyridazine. The article was titled 《Studies on pyridazines. XXVI. The reaction of substituted N-acetyliminopyridazinium ylides with benzyne》. The information in the text is summarized as follows:

Reaction of N-acetyliminopyridazinium ylides I (R = Me, MeO, EtO, Ph, piperidino; R1 = R2 = H; R = MeO, R1 = Me, R2 = H; R = MeO, R1 = H, R2 = Me) with benzyne gave 1,3-dipolar cycloadducts II. Photolysis of II (R = MeO, EtO; R1 = R2 = H) gave α-alkoxynaphthalene and 3-(2-acetamidophenyl)pyridazines. Photolysis of II (R = Me, R1 = R2 = H) gave the indazolo[2,3-b]pyridazine (III). Reaction of II (R = MeO, Ph; R1 = R2 = H) with base gave 3-vinylindazole and the dihydroindazolopyridazine IV (R3 = MeO, Ph). Reaction of 3-pyridazinol 1-oxide with benzyne gave a 1,3-cycloadduct, which underwent N-O bond fission to give the pyridazinone V. In the experiment, the researchers used 3-Ethoxypyridazine(cas: 62567-44-6Category: pyridazine)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

《Hydrophobicity parameters determined by reversed-phase liquid chromatography. IX. Relationship between capacity factor and water-octanol partition coefficient of monosubstituted pyrimidines》 was written by Yamagami, Chisako; Yokota, Miho; Takao, Narao. HPLC of Formula: 62567-44-6 And the article was included in Chemical & Pharmaceutical Bulletin on April 30 ,1994. The article conveys some information:

The capacity factors, k’, of 2- and 5-substituted pyrimidines were determined by reversed-phase high performance liquid chromatog. (RPLC). The log k’ values were correlated with log P by using correction terms for the hydrogen-bond effects of the aza functions of the diazine ring and the substituent. By analogy with the case of the pyrazine series previously studied, a correlation equation with indicator variables categorizing the type and strength of the substituent hydrogen-bonding, and the elec. constant of substituents as addnl. parameters was obtained to describe the correlation between log k’ and log P. Suitable mobile-phase conditions to predict reliable log P values are proposed. In the experiment, the researchers used many compounds, for example, 3-Ethoxypyridazine(cas: 62567-44-6HPLC of Formula: 62567-44-6)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.HPLC of Formula: 62567-44-6

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Wang, Pan; Yang, Zhenlin; Wang, Ziwei; Xu, Chenyang; Huang, Lei; Wang, Shengchun; Zhang, Heng; Lei, Aiwen. Computed Properties of C6H8N2O. The article was titled 《Electrochemical Arylation of Electron-Deficient Arenes through Reductive Activation》. The information in the text is summarized as follows:

An electrochem. method has been developed to achieve arylation of electron-deficient arenes through reductive activation. Various electron-deficient arenes and aryldiazonium tetrafluoroborates are amenable to this transformation within the conditions of an undivided cell, providing the desired products in up to 92 % yield. Instead of preparing diazonium reagents, these reactions can begin from anilines, and they can be carried out in one pot. ESR studies indicate that cathodic reduction of quinoxaline occurs using the transformation. Moreover, cyclic voltammetry indicates that both quinoxaline and aryl diazonium salt have relatively low reduction potentials, which suggests they can be activated through reduction during the reaction. The experimental part of the paper was very detailed, including the reaction process of 3-Ethoxypyridazine(cas: 62567-44-6Computed Properties of C6H8N2O)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Computed Properties of C6H8N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The author of 《The mechanism of thermal eliminations. Part 19. Relative rates of pyrolysis of 2-ethoxypyrazine, 3-ethoxypyridazine, 2- and 4-ethoxypyrimidine, 3-chloro-6-ethoxypyridazine, and 2-chloro-4-ethoxypyrimidine: the effect of the aza ‘substituent’ and π-bond order on the elimination rate》 were Al-Awadi, Nouria; Taylor, Roger. And the article was published in Journal of the Chemical Society in 1986. Formula: C6H8N2O The author mentioned the following in the article:

The kinetics were examined of the 1st-order thermal decomposition of the title compounds into C2H4 and the corresponding aza-substituted pyridines at 650-713 K. The electronic effects of the aza substituent are small; a more important factor appears to be the C-N π-bond order, which accounts for the high reactivity of the pyridazines. The substituent effects of the Cl and aza groups are explicable in terms of the balance between electron withdrawal from the C-O bond, producing activation, and from the N in the cyclic transition state, producing deactivation. The most important reaction step is cleavage of the C-O bond. The statistically corrected rate (per ring N atom) of 2-ethoxypyrimidine is unexpectedly low. This may reflect difficulty in achieving the coplanar transition state in which the lone pairs in the s-orbitals of O and N not involved in the elimination are brought into close proximity. The experimental process involved the reaction of 3-Ethoxypyridazine(cas: 62567-44-6Formula: C6H8N2O)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Formula: C6H8N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Recommanded Product: 62567-44-6On May 21, 1998 ,《Vicarious nucleophilic substitution of pyridazinium N-dicyanomethylides》 appeared in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry. The author of the article were Itoh, Takashi; Matsuya, Yuji; Nagata, Kazuhiro; Miyazaki, Michiko; Tsutsumi, Nozomi; Ohsawa, Akio. The article conveys some information:

Pyridazines have been allowed to react with tetracyanoethylene oxide to give pyridazinium N-dicyanomethylides, which are subjected to vicarious nucleophilic substitution to afford the corresponding 4-substituted derivatives in moderate to good yields. The dicyanomethylene group is readily eliminated by a radical reaction, and 4-substituted pyridazines are obtained. The results came from multiple reactions, including the reaction of 3-Ethoxypyridazine(cas: 62567-44-6Recommanded Product: 62567-44-6)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Recommanded Product: 62567-44-6

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

SDS of cas: 62567-44-6On October 21, 1995 ,《A regiospecific reaction of pyridazines with vicarious nucleophilic substitution via their dicyanomethylide derivatives》 was published in Journal of the Chemical Society, Chemical Communications. The article was written by Itoh, Takashi; Matsuya, Yuji; Nagata, Kazuhiro; Okada, Mamiko; Ohsawa, Akio. The article contains the following contents:

The phenyl(or p-tolyl)sulfonylmethyl group is introduced with complete regiospecificity to the C-4 position of 3-substituted pyridazines using vicarious nucleophilic substitution of pyridazinium dicyanomethylides. In the experiment, the researchers used many compounds, for example, 3-Ethoxypyridazine(cas: 62567-44-6SDS of cas: 62567-44-6)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.SDS of cas: 62567-44-6

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem