Category: 5788-60-3

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C7H9ClN2O, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 5788-60-3, name is 3-Chloro-6-propoxypyridazine. In an article，Which mentioned a new discovery about 5788-60-3

Glycogen synthase kinase 3 regulates glycogen synthase, the rate-determining enzyme for glycogen synthesis. Liver and muscle glycogen synthesis is defective in type 2 diabetics, resulting in elevated plasma glucose levels. Inhibition of GSK-3 could potentially be an effective method to control plasma glucose levels in type 2 diabetics. Structure-activity studies on a N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine series have led to the identification of potent and selective compounds with good cellular efficacy. Molecular modeling studies have given insights into the mode of binding of these inhibitors. Since the initial leads were also potent inhibitors of CDK-2/CDK-4, an extensive SAR was performed at various positions of the pyrazolo[1,5-b] pyridazin core to afford potent GSK-3 inhibitors that were highly selective over CDK-2. In addition, these inhibitors also exhibited very good cell efficacy and functional response. A representative example was shown to have good oral exposure levels, extending their utility in an in vivo setting. These inhibitors provide a viable lead series in the discovery of new therapies for the treatment of type 2 diabetes.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research. 5788-60-3 is helpful to your research. Formula: C7H9ClN2O

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2446 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: pyridazine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 5788-60-3, name is 3-Chloro-6-propoxypyridazine. In an article，Which mentioned a new discovery about 5788-60-3

N-phenyl-4-pyrazolo[1,5-6]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacy

Glycogen synthase kinase 3 regulates glycogen synthase, the rate-determining enzyme for glycogen synthesis. Liver and muscle glycogen synthesis is defective in type 2 diabetics, resulting in elevated plasma glucose levels. Inhibition of GSK-3 could potentially be an effective method to control plasma glucose levels in type 2 diabetics. Structure-activity studies on a N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine series have led to the identification of potent and selective compounds with good cellular efficacy. Molecular modeling studies have given insights into the mode of binding of these inhibitors. Since the initial leads were also potent inhibitors of CDK-2/CDK-4, an extensive SAR was performed at various positions of the pyrazolo[1,5-b] pyridazin core to afford potent GSK-3 inhibitors that were highly selective over CDK-2. In addition, these inhibitors also exhibited very good cell efficacy and functional response. A representative example was shown to have good oral exposure levels, extending their utility in an in vivo setting. These inhibitors provide a viable lead series in the discovery of new therapies for the treatment of type 2 diabetes.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 5788-60-3, help many people in the next few years.category: pyridazine

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2446 – PubChem

 

Application of 5788-60-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 5788-60-3, 3-Chloro-6-propoxypyridazine, introducing its new discovery.

Allylthiopyridazine derivatives and process for preparing the same

The, present invention relates to a novel allylthiopyridazine derivative represented by formula (I) which exhibits a superior effect for prevention and treatment or hepatic diseases induced by toxic substances and for protection of human tissues from radiation: STR1 or a pharmaceutically acceptable salt thereof, in which R1 represents halogen atom, lower alkoxy, dialkylaminoalkoxy, hydroxyalkoxy, phenoxy substituted or unsubstituted with lower alkyl, benzyloxy, or phenyl, and R2 and R3 independently of one another represent hydrogen or lower alkyl, or R2 and R3 together with carbon atom to which they are attached can form a saturated or unsaturated 6-membered ring, provided that R2 and R3 are other than hydrogen when R1 is chloro; and to a process for preparing thereof and a pharmaceutical composition containing the same as an effective component.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 5788-60-3. In my other articles, you can also check out more blogs about 5788-60-3

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2445 – PubChem