Category: 5788-58-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5788-58-9,4,5-Dibromopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

A solution of 4,5-dibromopyridazin-3(2H)-one (0.80 g, 3.15 mmol), trans-(2-(2-methoxyphenyl)cyclopropyl)methanamine (0.559 g, 3.15 mmol), and DIPEA (1.21 1 ml, 6.93 mmol) in DMA (6.66 ml) was heated to 100C for 16 h. The reaction was cooled, diluted with saturated sodium bicarbonate to give 4-bromo-5- (((2-(2-methoxyphenyl)cyclopropyl)methyl)amino)pyridazin-3(2H)-one as a tan precipitate that was filtered and air dried. LCMS: Rt = 1.0 min, (M+H)+ = 359.

As the paragraph descriping shows that 5788-58-9 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5788-58-9, 4,5-Dibromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4,5-dibromo-2,3-dihydropyridazin-3-one (90.4 mg, 0.36 mmol, 1.2 equiv.) in DMA(2 mL, 21.51 mmol) were added 3-[(2-methylphenyl)methyl]-3,6- diazabicyclo[3.1.1]heptane (60 mg, 0.30 mmol, 1 equiv.) and DIEA(76.7 mg, 0.59 mmol, 2 equiv.) at room temperature. The resulted mixture was stirred for 16 h at 100 degrees C. The reaction mixture was purified by Prep-HPLC with the following conditions (Column: XBridge Prep C18 OBD Column 19X150mm 5um; Mobile Phase A: Water(10 mmol/L NH4HCO3), Mobile Phase B: MeCN; Flow rate: 20 mL/min; Gradient: 35% B to 65% B in 9 min; 254 nm; Rt: 7.4 min) to afford 4-bromo-5-[3-[(2-methylphenyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-6- yl]-2,3-dihydropyridazin-3-one (5.1 mg, 4.58%) as a light yellow solid

The synthetic route of 5788-58-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GOLDFINCH BIO, INC.; YU, Maolin; DANIELS, Matthew, H.; HARMANGE, Jean-christophe, P.; TIBBITTS, Thomas, T.; LEDEBOER, Mark, W.; WALSH, Liron; MUNDEL, Peter, H.; MALOJCIC, Goran; (860 pag.)WO2019/55966; (2019); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem