Category: 57041-95-9

57041-95-9, 6-Aminopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57041-95-9, Step 32.1: 6-amino-2-methylpyridazin-3(2H)-one A mixture of 6-aminopyridazin-3-ol (2 g, 18.00 mmol), NaOH (0.720 g, 18.00 mmol) and MeI (1.126 mL, 18.00 mmol) was stirred for 2.5 hr at 85 C. under Ar. The reaction mixture was concentrated. The crude material was purified by silica gel column chromatography (NH3 1%/CH2Cl2/MeOH 4-7%) to afford the title product (538 mg, 4.30 mmol, 24% yield) as a yellow solid. tR: 0.25 min (LC-MS 2); ESI-MS: 126 [M+H]+ (LC-MS 2); Rf=0.36 (CH2Cl2/MeOH 9:1).

As the paragraph descriping shows that 57041-95-9 is playing an increasingly important role.

Reference：
Patent; NOVARTIS AG; BLANK, Jutta; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; US2014/349990; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57041-95-9,6-Aminopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

57041-95-9, A mixture of 6-aminopyridazin-3-ol (2 g, 18.00 mmol), NaOH (0.720 g, 18.00 mmol) and Mel (1.126 mL, 18.00 mmol) was stirred for 2.5 hr at 85 00 under Ar. The reaction mixture was concentrated. The crude material was purified by silica gel column chromatography (NH3 1% ICH2CI2/MeOH 4-7%) to afford the title product (538 mg, 4.30 mmol, 24 % yield) as a yellowsolid. tR: 0.25 mm (LC-MS 2); ESI-MS: 126 [M+H] (LC-MS 2); R = 0.36 (CH2CI2/MeOH 9:1).

The synthetic route of 57041-95-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NOVARTIS AG; BLANK, Jutta; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; WO2014/191896; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

57041-95-9, 6-Aminopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57041-95-9, Step 32.1: 6-amino-2-methylpyridazin-3(2H)-one A mixture of 6-aminopyridazin-3-ol (2 g, 18.00 mmol), NaOH (0.720 g, 18.00 mmol) and MeI (1.126 mL, 18.00 mmol) was stirred for 2.5 hr at 85 C. under Ar. The reaction mixture was concentrated. The crude material was purified by silica gel column chromatography (NH3 1%/CH2Cl2/MeOH 4-7%) to afford the title product (538 mg, 4.30 mmol, 24% yield) as a yellow solid. tR: 0.25 min (LC-MS 2); ESI-MS: 126 [M+H]+ (LC-MS 2); Rf=0.36 (CH2Cl2/MeOH 9:1).

As the paragraph descriping shows that 57041-95-9 is playing an increasingly important role.

Reference：
Patent; NOVARTIS AG; BLANK, Jutta; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; US2014/349990; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57041-95-9,6-Aminopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

57041-95-9, A mixture of 6-aminopyridazin-3-ol (2 g, 18.00 mmol), NaOH (0.720 g, 18.00 mmol) and Mel (1.126 mL, 18.00 mmol) was stirred for 2.5 hr at 85 00 under Ar. The reaction mixture was concentrated. The crude material was purified by silica gel column chromatography (NH3 1% ICH2CI2/MeOH 4-7%) to afford the title product (538 mg, 4.30 mmol, 24 % yield) as a yellowsolid. tR: 0.25 mm (LC-MS 2); ESI-MS: 126 [M+H] (LC-MS 2); R = 0.36 (CH2CI2/MeOH 9:1).

The synthetic route of 57041-95-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NOVARTIS AG; BLANK, Jutta; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; WO2014/191896; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

57041-95-9, 6-Aminopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57041-95-9, Step 32.1: 6-amino-2-methylpyridazin-3(2H)-one A mixture of 6-aminopyridazin-3-ol (2 g, 18.00 mmol), NaOH (0.720 g, 18.00 mmol) and MeI (1.126 mL, 18.00 mmol) was stirred for 2.5 hr at 85 C. under Ar. The reaction mixture was concentrated. The crude material was purified by silica gel column chromatography (NH3 1%/CH2Cl2/MeOH 4-7%) to afford the title product (538 mg, 4.30 mmol, 24% yield) as a yellow solid. tR: 0.25 min (LC-MS 2); ESI-MS: 126 [M+H]+ (LC-MS 2); Rf=0.36 (CH2Cl2/MeOH 9:1).

As the paragraph descriping shows that 57041-95-9 is playing an increasingly important role.

Reference：
Patent; NOVARTIS AG; BLANK, Jutta; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; US2014/349990; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57041-95-9,6-Aminopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

57041-95-9, A mixture of 6-aminopyridazin-3-ol (2 g, 18.00 mmol), NaOH (0.720 g, 18.00 mmol) and Mel (1.126 mL, 18.00 mmol) was stirred for 2.5 hr at 85 00 under Ar. The reaction mixture was concentrated. The crude material was purified by silica gel column chromatography (NH3 1% ICH2CI2/MeOH 4-7%) to afford the title product (538 mg, 4.30 mmol, 24 % yield) as a yellowsolid. tR: 0.25 mm (LC-MS 2); ESI-MS: 126 [M+H] (LC-MS 2); R = 0.36 (CH2CI2/MeOH 9:1).

The synthetic route of 57041-95-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NOVARTIS AG; BLANK, Jutta; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; WO2014/191896; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem