Archives for Chemistry Experiments of 6-Methoxypyridazine-3-carboxylic acid

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Aralkyltriazole compounds

1-phenyl-lower alkyl-1H-1,2,3-triazole compounds of the formula STR1 in which Ph represents phenyl substituted by up to and including 3 substituents selected from lower alkyl, halogen and trifluoromethyl, alk represents lower alkylidene, and wherein either R1 represents hydrogen, lower alkyl, lower alkoxy, amino, N-lower alkylamino, N,N-di-lower alkylamino, N-lower alkanoylamino, carbamoyl, N-lower alkanoylcarbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl and R2 represents carbamoyl, N-lower alkanoylcarbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl or R1 represents carbamoyl, N-lower alkanoylcarbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl and R2 represents hydrogen or lower alkyl, have anti-convulsive properties and can be used as medicaments.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1992 – PubChem

 

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Influence of Fluorination on the Conformational Properties and Hydrogen-Bond Acidity of Benzyl Alcohol Derivatives

The effect of fluorination on the conformational and hydrogen-bond (HB)-donating properties of a series of benzyl alcohols has been investigated experimentally by IR spectroscopy and theoretically with quantum chemical methods (ab initio (MP2) and DFT (MPWB1K)). It was found that o-fluorination generally resulted in an increase in the HB acidity of the hydroxyl group, whereas a decrease was observed upon o,o?-difluorination. Computational analysis showed that the conformational landscapes of the title compounds are strongly influenced by the presence of o-fluorine atoms. Intramolecular interaction descriptors based on AIM, NCI and NBO analyses reveal that, in addition to an intramolecular OH…F interaction, secondary CH…F and/or CH…O interactions also occur, contributing to the stabilisation of the various conformations, and influencing the overall HB properties of the alcohol group. The benzyl alcohol HB-donating capacity trends are properly described by an electrostatic potential based descriptor calculated at the MPWB1K/6-31+G(d,p) level of theory, provided solvation effects are taken into account for these flexible HB donors.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1997 – PubChem

 

A new application about 56434-28-7

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CYANO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE

The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1994 – PubChem

 

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Chemoselective reduction of the carbonyl functionality through hydrosilylation: Integrating click catalysis with hydrosilylation in one pot

Herein we report the chemoselective reduction of the carbonyl functionality via hydrosilylation using a copper(I) catalyst bearing the abnormal N-heterocyclic carbene 1 with low (0.25 mol %) catalyst loading at ambient temperature in excellent yield within a very short reaction time. The hydrosilylation reaction of alpha,beta-unsaturated carbonyl compounds takes place selectively toward 1,2-addition (C=O) to yield the corresponding allyl alcohols in good yields. Moreover, when two reducible functional groups such as imine and ketone groups are present in the same molecule, this catalyst selectively reduces the ketone functionality. Further, 1 was used in a consecutive fashion by combining the Huisgen cycloaddition and hydrosilylation reactions in one pot, yielding a range of functionalized triazole substituted alcohols in excellent yields.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2001 – PubChem

 

Awesome Chemistry Experiments For 6-Methoxypyridazine-3-carboxylic acid

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Novel compounds and their use

A compound of the general formula (I): 1wherein R1, R2, X, Y and Z are as described in the specification.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1990 – PubChem

 

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Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use

The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1995 – PubChem

 

Properties and Exciting Facts About 6-Methoxypyridazine-3-carboxylic acid

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Thermodynamic study on the gas chromatographic separation of the enantiomers of aromatic alcohols using heptakis(2,3-di-O-methyl-6-O-tert- butyldimethylsilyl)-beta-cyclodextrin as a stationary phase

Gas chromatographic separation of the enantiomers of nineteen structurally related aromatic alcohols was investigated as a function of temperature using a heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-beta-cyclodextrin- coated capillary column. Thermodynamic parameters were determined and compared with those obtained with the nonchiral, reference stationary phase, OV-1701. While the -DeltaH and -DeltaS values for the more retained enantiomers of all nineteen alcohols are comparable on the chiral stationary phase used, the -Delta(DeltaH) and -Delta(DeltaS) values are considerably different. Of all the solutes tested, enantiodiscrimination was the greatest for the 2,6-difluoro-alpha-methylbenzyl alcohol.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2002 – PubChem