Category: 5469-70-5

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Gaddam, Lakshmi Teja and a compound is mentioned, 5469-70-5, 3-Aminopyridazine, introducing its new discovery. 5469-70-5

Synthesis of carboxamide and sulfonyl carboxamide linked heterocycles under green conditions

Direct coupling of heteroaldehydes with heteroaryl amines / sulfonylamines is performed under green conditions using PEG-400 in the presence of oxidant CCl3CN/H2O2. The presence of electron withdrawing substituents on heteroaldehydes increased the yield. Further heteroaryl amines favor the reaction when compared with heteroaryl sulfonylamines.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N71 – PubChem

 

5469-70-5, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 5469-70-5, name is 3-Aminopyridazine, introducing its new discovery.

BENZOPHENONE DERIVATIVES USEFUL FOR INHIBITING FORMATION OF MICROTUBULE

Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeutic drugs. The benzophenone derivatives have an inhibition activity of microtubule formation and can be used to treat a normal proliferative state of a malignant tumor by killing the actively proliferating cells.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.5469-70-5, you can also check out more blogs about5469-70-5

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Pyridazine – Wikipedia,
Pyridazine | C4H4N12 – PubChem

 

5469-70-5, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 5469-70-5, molcular formula is C4H5N3, introducing its new discovery.

POLYHYDROXY BENZOIC ACID DERIVATIVES AND THEIR USE AS NEURAMINIDASE INHIBITORS

The present invention is directed to compositions of the formula: wherein: R2 is H, or an alkyl group having 1 to 3 carbon atoms and 0 to 2 hydroxyls; R3 is H, or hydroxyl; R4 is H, or forms a hydrolyzable ester or amide with -C02-; R5 are H, or are taken together to form =NH; and R6 comprises an amine, or a group having 1 to 12 carbon atoms and 1 to 3 amine groups. The invention is also directed to methods of inhibiting the activity of neuraminidase using the compounds of the invention

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 5469-70-5, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 5469-70-5

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Pyridazine – Wikipedia,
Pyridazine | C4H4N33 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5469-70-5,3-Aminopyridazine,as a common compound, the synthetic route is as follows.

A RBF was charged with (P)-perfluorophenyl 2-oxo-1-(2,3′,4′-trifluoro-5-methoxy-[1,1′-biphenyl]-4-yl)-1,2-dihydroquinoline-6-sulfonate (151.1 mg, 0.241 mmol) and pyridazin-3-amine (34.4 mg, 0.361 mmol). DMSO (602 mul) was added to give a solution which was then diluted with THF (1806 mul). The flask was cooled in an ice-water bath for 10 min, then lithium bis(trimethylsilyl)amide (1M in THF) (530 mul, 0.530 mmol) was added dropwise. After 15 min total, the mixture was diluted with 1N aq. HCl and EtOAc. The layers were separated, and the aq. layer was extracted with EtOAc (1*). The combined organic extracts were dried over sodium sulfate, filtered, and concentrated. The residue was taken up in MeOH and filtered through a 0.2 micron filter. The resulting solution was purified by reverse-phase HPLC (25-70% CH3CN/H2O with 0.1% TFA). Fractions containing the desired product were combined and lyophilized to give (P)-2-oxo-N-3-pyridazinyl-1-(2,3′,4′-trifluoro-5-methoxy-4-biphenylyl)-1,2-dihydro-6-quinolinesulfonamide (55 mg, 0.102 mmol, 42.4% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) delta=14.5 (br. s, 1H), 8.52-8.06 (m, 3H), 8.01-7.76 (m, 3H), 7.76-7.30 (m, 5H), 6.91-6.62 (m, 2H), 3.73 (br. s., 3H). m/z (ESI) 539.0 (M+H)+., 5469-70-5

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Reference£º
Patent; Amgen Inc.; Weiss, Matthew; Boezio, Alessandro; Boezio, Christiane; Butler, John R.; Chu-Moyer, Margaret Yuhua; Dimauro, Erin F.; Dineen, Thomas; Graceffa, Russell; Guzman-Perez, Angel; Huang, Hongbing; Kreiman, Charles; La, Daniel; Marx, Isaac E.; Milgrim, Benjamin Charles; Nguyen, Hanh Nho; Peterson, Emily; Romero, Karina; Sparling, Brian; US9212182; (2015); B2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5469-70-5

General procedure: To a slurry of 6?-bromo-8?-methyl-2?H-spiro[cyclohexane-1,3?-imidazo[1,5-a]pyridine]-1?,5?-dione (12) and aromatic aminederivatives (1.2 eq) in 1,4-dioxane was added Cs2CO3 (3 eq). Themixture was stirred at room temperature for 20 min under nitrogen.To the mixture was then added Pd(OAc)2 (0.1 eq) and Xantphos(0.2 eq). After stirred at room temperature for additional 20 minunder nitrogen, the mixture was heated at 95 C for 12 h undernitrogen. The mixture was concentrated in vacuo, added with water,stirred and filtered. The filter cake was dried and purified by flashcolumn chromatography.

5469-70-5 3-Aminopyridazine 230373, apyridazine compound, is more and more widely used in various fields.

Reference£º
Article; Yuan, Xinrui; Wu, Hanshu; Bu, Hong; Zheng, Peiyuan; Zhou, Jinpei; Zhang, Huibin; Bioorganic and Medicinal Chemistry; vol. 27; 7; (2019); p. 1211 – 1225;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under an atmosphere of nitrogen, a 25 mL dry Schlenk flask was placed with Cu(acac)2 (1.6 mg, 0.01 mmol) and ligand A (2.6 mg, 0.012 mmol). Anhydrous MeOH (1.0 mL) was added, and the mixture was magnetically stirred at 20 C for 15 min. Then a solution of 1-phenylprop-2-yn-1-yl acetate 2a (0.24 mmol), 2-aminopyridine 1a (0.2 mmol) and diisopropylethylamine (0.07 mL, 0.4 mmol) in MeOH (0.5 mL) were added dropwise. The reaction flask was kept at room temperature for 6 h. After 1a was completely consumed as monitored by TLC, H2O (10 mL) was added to quench the reaction. The resulting mixture was then extracted three times with diethyl ether (10 mL*3). The combined organic layer was dried over Na2SO4. After evaporation of the volatile solvent under reduced pressure, the residue was purified by flash chromatography on silica gel to afford pure 3a (39 mg, 0.19 mmol) as a brown oil in a yield of 94%., 5469-70-5

The synthetic route of 5469-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cheng, Cang; Ge, Luo; Lu, Xuehe; Huang, Jianping; Huang, Haocheng; Chen, Jie; Cao, Weiguo; Wu, Xiaoyu; Tetrahedron; vol. 72; 43; (2016); p. 6866 – 6874;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-methyl-8-morpholino-6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-3-carboxylic acid (23.0 mg, 0.057 mmol) and 3-aminopyridazine (16.0 mg, 0.170 mmol) were dissolved in MeCN (1.2 mL). HATU (32.0 mg, 0.085 mmol) and pyridine (0.014 mL, 0.170 mmol) were added and the vial was sealed and heated to 50 C for 1 h, then to 80 C for 2 h. The reaction was cooled to room temp and bicarb (2 mL) and water (1 mL) were added. The mixture was extracted with EtOAc (3×5 mL) but there was precipitate in the organic layer. The solid was collected by filtration and washed with diethyl ether, and dried in vacuo to give 2-methyl-8-morpholino-N-(pyridazin-3-yl)-6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-3-carboxamide (8.0 mg, 29%). MS (ESI) calcd for C23H20F3N702: 483.16; found: 484 [M+H], 5469-70-5

5469-70-5 3-Aminopyridazine 230373, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; WO2013/59587; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5469-70-5,3-Aminopyridazine,as a common compound, the synthetic route is as follows.

A flask was charged with perfluorophenyl 1-(4-bromo-2-methoxyphenyl)-2-oxo-1,2-dihydroquinoline-6-sulfonate (3.33 g, 5.78 mmol) and pyridazin-3-amine (0.659 g, 6.93 mmol). A septum was attached and THF (28.9 ml) was added. The mixture was cooled to 0 C. and a THF solution of lithium bis(trimethylsilyl)amide (12.13 ml, 12.13 mmol, 1 M) was added dropwise to give a brown solution. The solution was maintained at 0 C. for 20 min. The reaction mixture was partitioned between 1 N HCl (200 mL) and EtOAc (200 mL), the layers were separated and the aqueous layer was extracted with DCM (100 mL) and EtOAc (200 mL). The combined organic layers were dried (Na2SO4) and concentrated to provide 1-(4-bromo-2-methoxyphenyl)-2-oxo-N-(pyridazin-3-yl)-1,2-dihydroquinoline-6-sulfonamide (3.39 g, 6.96 mmol, 120% yield) as a light yellow foam. Although contaminated with solvent, the product was of sufficient purity for use in the next step. m/z (ESI) 485.1 (M-H)-.

5469-70-5, As the paragraph descriping shows that 5469-70-5 is playing an increasingly important role.

Reference£º
Patent; Amgen Inc.; Weiss, Matthew; Boezio, Alessandro; Boezio, Christiane; Butler, John R.; Chu-Moyer, Margaret Yuhua; Dimauro, Erin F.; Dineen, Thomas; Graceffa, Russell; Guzman-Perez, Angel; Huang, Hongbing; Kreiman, Charles; La, Daniel; Marx, Isaac E.; Milgrim, Benjamin Charles; Nguyen, Hanh Nho; Peterson, Emily; Romero, Karina; Sparling, Brian; US9212182; (2015); B2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

5469-70-5,5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A microwave tube was charged with 6′-bromo-8′-chloro-2’H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione 3 (1.00 eq.), amine (1.00 eq.), Cs2CO3 (2.00 eq.), Pd2(dba)3 (0.10 eq.), xantphos (0.10 eq.) and 1,4-dioxane (4 mL). The reaction mixture was heated under microwave irradiation at 130 C for 30 min, concentrated under reduced pressure, and purified by flash column chromatography (silica gel, DCM ramping to DCM/CH3OH = 9:1) to yield the desired product.

As the paragraph descriping shows that 5469-70-5 is playing an increasingly important role.

Reference£º
Article; Abdelaziz, Ahmed M.; Basnet, Sunita K.C.; Islam, Saiful; Li, Manjun; Tadesse, Solomon; Albrecht, Hugo; Gerber, Cobus; Yu, Mingfeng; Wang, Shudong; Bioorganic and Medicinal Chemistry Letters; vol. 29; 18; (2019); p. 2650 – 2654;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5469-70-5

Phenyl pyridazin-3-ylcarbamateTo a solution of 3-amino-6-chloropyridazine (19.2 g,148 mmol; CASNo. 5469-69-2) in EtOH (500 mL) was added 10% Pd catalyst on 1940 carbon (unreduced, 55% water). Triethylamine (50 mL) was added and the mixture was hydrogenated under 500 psi/mole for 1.9 h. The reaction was filtered and the ethanol was washed with aqueous NH4CI. The organic layer was concentrated to give pyridazin-3-amine as a white solid (11 g, 78% yield). MS (APCI 10V) AP+ 1 96.2. To a suspension of pyridazin-3-amine (5 g, 50 mmol) in THF (50 mL) and CH3CN (70 mL) was added pyridine (5.10 mL, 63.1 mmol) followed by phenyl chloroformate (6.95 mL, 55.2 mmol) slowly. The reaction was stirred overnight. The reaction was filtered to remove the precipitate. The filtrate was concentrated and then taken up in CH2CI2 which was then washed with water. The organic layer was dried using SPE phase separators and concentrated. The residue was purified by silica gel column chromatography (0-5% MeOH/CH2CI2). An undesired side product eluted first followed by the title compound which was concentrated to give a white solid (7.5 g, 70% yield). MS (APCI 10V) AP+1 216.12; 1H NMR (400 MHz, DMSO-d6) delta ppm 7.20 – 7.24 (m, 2 H) 7.25 – 7.28 (m, 1 H) 7.39 – 7.44 (m, 2 H) 7.64 – 7.69 (m, 1 H) 8.05 (dd, 1 H) 8.94 (dd, 1 H) 11.34 (s, 1 H).

As the paragraph descriping shows that 5469-70-5 is playing an increasingly important role.

Reference£º
Patent; PFIZER INC.; LONG, Scott Allen; MEYERS, Marvin Jay; PELC, Matthew James; SCHWEITZER, Barbara Ann; THORARENSEN, Atli; WANG, Lijuan Jane; WO2010/58318; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem