Category: 53896-49-4

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: Pyridazine-3-carbonitrile, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 53896-49-4, Name is Pyridazine-3-carbonitrile, molecular formula is C5H3N3

C?H Cyanation of 6-Ring N-Containing Heteroaromatics

Heteroaromatic nitriles are important compounds in drug discovery, both for their prevalence in the clinic and due to the diverse range of transformations they can undergo. As such, efficient and reliable methods to access them have the potential for far-reaching impact across synthetic chemistry and the biomedical sciences. Herein, we report an approach to heteroaromatic C?H cyanation through triflic anhydride activation, nucleophilic addition of cyanide, followed by elimination of trifluoromethanesulfinate to regenerate the cyanated heteroaromatic ring. This one-pot protocol is simple to perform, is applicable to a broad range of decorated 6-ring N-containing heterocycles, and has been shown to be suitable for late-stage functionalization of complex drug-like architectures.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: Pyridazine-3-carbonitrile, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 53896-49-4, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N192 – PubChem

 

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SOLUBLE GUANYLATE CYCLASE ACTIVATORS

A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body’s production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I , or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof

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Pyridazine – Wikipedia,
Pyridazine | C4H4N181 – PubChem

 

Application of 53896-49-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 53896-49-4, molcular formula is C5H3N3, introducing its new discovery.

SOLUBLE GUANYLATE CYCLASE ACTIVATORS

The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body”s production of cyclic guanosine monophosphate (“”cGMP””) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 53896-49-4 is helpful to your research. Application of 53896-49-4

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Pyridazine – Wikipedia,
Pyridazine | C4H4N182 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 53896-49-4, name is Pyridazine-3-carbonitrile, introducing its new discovery. Product Details of 53896-49-4

New pyridazine endothelin antagonists

Compounds of formula (I) have affinity for endothelin receptors, are selective for ETAover ETB, and are potentially useful in the treatment of conditions mediated by endothelin.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 53896-49-4, and how the biochemistry of the body works.Product Details of 53896-49-4

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Pyridazine – Wikipedia,
Pyridazine | C4H4N174 – PubChem

 

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Synthesis and Selective Reactions of v-Triazolo<1,5-b>pyridazinium Salts with Nucleophiles. A Facile Access to Functionalized Ethenyl-1,2,3-triazoles

v-Triazolo<1,5-b>pyridazinium salts 5a-c synthesized from alpha-pyridazinyl ketone arylhydrazones and 2,4,4,6-tetrabromocyclohexa-2,5-dien-1-one (TBB) reacted selectively with nucleophiles to yield – besides substituted derivatives 6 – ring-opened cyano compound 9 and/or v-triazoles containing olefinic side chain 10-12.Mechanistic considerations reveal that cation 5 reacts with nucleophiles predominantly at C-7 unless other positions are especially activated.This selectivity proved to be in good agreement with results of semiempirical quantum chemical calculations.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N198 – PubChem

 

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Metal ion chelates of lipophilic alkyl diazinyl ketoximes as hydrolytic catalysts

A series of lipophilic dodecyl hetaryl ketoximes (hetaryl = pyridin-2-yl, pyridazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrazin-2-yl as well as their methyl hetaryl homologues was synthesized and hydrolytic activity of their chelates with Co2+, Ni2+, Cu2+ and Zn2+ in a micellar matrix of hexadecyltrimethylammonium bromide or in homogeneous aqueous solutions was investigated using 4-nitrophenyl acetate, 4-nitrophenyl hexanoate and 4-nitrophenyl diphenyl phosphate as model substrates. While Co2+ and Cu2+ chelates are almost inactive, those of Ni2+ and Zn2+ exhibit considerable activity. None of the studied chelates promotes hydrolysis of the used phosphate. The effective species are chelates of the metal : ligand stoichiometry 1 : 3 and 1 : 1 with Ni2+ and Zn2+, respectively, when the ester cleavage proceeds in the micellar matrix. The 1 : 2 stoichiometry was found in aqueous solutions of Ni2+ and Zn2+ chelates of methyl ketoximes.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N187 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. name: Pyridazine-3-carbonitrile, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 53896-49-4

SUBSTITUTED PYRIMIDINES

Disclosed are substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions

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Pyridazine – Wikipedia,
Pyridazine | C4H4N183 – PubChem

 

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Model Studies toward the Total Synthesis of Thebaine by an Intramolecular Cycloaddition Strategy

Three model compounds required for an approach to thebaine by intramolecular [4+2] cycloaddition were prepared. In the first two cases the anticipated cycloaddition products were obtained under thermal conditions. Thermolysis of the third, more advanced model compound, afforded products resulting from rearrangements and/or elimination. A study of analogous intra- and intermolecular reactions using benzofuran as dienophile and various electron-poor and electron-rich dienes (pyridazines, pyranones, Danishefsky diene) was undertaken.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N195 – PubChem

 

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Synthesis and antiviral activity of thiosemicarbazone derivatives of pyridazinecarbaldehydes and alkyl pyridazinyl ketones

Various novel thiosemicarbazones (TSCs) 15b-e, 16b-e, 17b-e, 18b-e, and 19b-e derived from 4-pyridazinecarbaldehyde, 3-pyridazinecarbaldehyde, 4-acetylpyridazine, 3-acetylpyridazine, and 3-propionylpyridazine were prepared and their cytotoxic and antiherpetic potentials were evaluated. It was found that the replacement of the 2-pyridyl-moiety in aldehyde derived compounds 20a-c by a 4-pyridazinyl group (compounds 15b-d) abolishes biological activity. However, in TSCs derived from 3-pyridazinecarbaldehyde (16b-d) the cytotoxic potency was considerably reduced (factor ~300), while the antiviral activity was largely retained. A total loss of biological activity occurred when the pyridyl group in TSC 20d, derived from 2-acetylpyridine, was replaced by the 4-pyridazinyl system (17d). By employment of the 3-pyridazinyl unit for isosteric modification, however, the cell toxicity could be reduced significantly (factor 100) without impairing the antiherpetic potential also in the series of TSCs derived from N-heteroaromatic ketones. It was observed that there is no obvious influence of the size of the cycloamino substituent on the biological activities in compounds 20a-d, 15b-d, 16b-d, 17b-d, and 18b-d. While the pyridine derived TSCs in our experiments proved clearly cytotoxic at lower concentrations than those being antivirally active, the aza-analogous compounds derived from 3-acetyl-pyridazine (18b-e) inhibited plaque formation at concentrations equal to those causing cytotoxic effects. The TSCs 16b-e derived from 3-pyridazinecarbaldehyde were found to show selective antiviral activity against HSV-1. In addition, a significant improvement of the water solubility of heteroaromatic TSCs could be achieved by the replacement of the CH-moiety in position 6 of the pyridine derivatives 20a-c by a nitrogen atom (compounds 16b-d).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N191 – PubChem

 

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SUBSTITUTED PYRIMIDINES

The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions

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Pyridazine – Wikipedia,
Pyridazine | C4H4N178 – PubChem