Category: 53180-92-0

Application of 53180-92-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.53180-92-0, Name is 5-Chloropyridazin-4-amine, molecular formula is C4H4ClN3. In a Patent，once mentioned of 53180-92-0

CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 53180-92-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N710 – PubChem

 

Application of 53180-92-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 53180-92-0, 5-Chloropyridazin-4-amine, introducing its new discovery.

COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I) or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 53180-92-0. In my other articles, you can also check out more blogs about 53180-92-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N708 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 5-Chloropyridazin-4-amine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 53180-92-0, Name is 5-Chloropyridazin-4-amine, molecular formula is C4H4ClN3

Synthetic method 5-chloro -4-aminopyridazine (by machine translation)

The invention relates to the technical field, of chemical synthesis 5 – and particularly discloses,aminopyridazine-3,6 -aminopyridazine as a starting material, and a synthetic route, of 4 -aminopyridin, chloro N – obtained by hydrogenation dechlorination (NCS) to yield, amino pyridazine key intermediate 5 – with .5 – chlorine – 4 4-aminopyridazine as an important intermediate, for drug synthesis, in particular to commercialized mass production, of the synthetic route, of the present invention for the first time to obtain. chlorine – 4 4-aminopyridazine, in a high yield and. high purity for the first time, 5 . (by machine translation)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 5-Chloropyridazin-4-amine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 53180-92-0, in my other articles.

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N711 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 5-Chloropyridazin-4-amine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 53180-92-0

1,2-PYRIDAZINES, 1,6-PYRIDAZINES AND PYRIMIDINES

This invention relates to novel 1,2-pyridazines, 1,6-pyridazines or pyrimidines of the formula wherein B1 to B3 an d R1 to R7 are as defined in the descrip-tion and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may therefore be useful as medicaments for the treatment of diseases such as type II diabetes.

If you are interested in 53180-92-0, you can contact me at any time and look forward to more communication. Recommanded Product: 5-Chloropyridazin-4-amine

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N709 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53180-92-0,5-Chloropyridazin-4-amine,as a common compound, the synthetic route is as follows.,53180-92-0

Preparation 9.2: 5-(2-methylpyridin-3-yl)pyridazin-4-amine 7v [00288] A mixture of 5-chloropyridazin-4-amine (50 mg, 0.386 mmol), (2-methyl-3- pyridyl)boronic acid (63.43 mg, 0.463 mmol), palladium triphenylphosphane (22.3 mg, 0.0193 mmol) and a2C03 (386 mu^ of 2M, 0.772 mmol) in dioxane (2 mL) was heated at 140C for lh. The mixture was then cooled to room temperature and partitioned between DCM and water. The organic layer was filtered through a SCX column, eluting with a 2M solution of H3 in MeOH. The eluate was concentrated in vacuo to give the title compound 7v (72 mg, 100% Yield).

The synthetic route of 53180-92-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; BRENCHLEY, Guy; CHARRIER, Jean-damien; DAVIS, Chris; DURRANT, Steven; JARDI, Gorka, Etxebarria I; FRAYSSE, Damien; JIMENEZ, Juan-miguel; KAY, David; KNEGTEL, Ronald; PIERARD, Francoise; PINDER, Joanne; SHAW, David; STORCK, Pierre-henri; STUDLEY, John; TWIN, Heather; WO2014/143241; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem