Category: 51355-94-3

51355-94-3, 6-Bromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 250-mL round-bottom flask was placed a solution of 2- chloro-N-[4-(trifluoromethyl)phenyl]propanamide (3 g, 11.92 mmol, as prepared in Example 1, step A) in acetone (120 mL) then K2CO3 (4.93 g, 35.67 mmol) and 6-bromo-2,3-dihydropyridazin-3-one (2.48 g, 14.17 mmol) were added. The reaction was heated to reflux for 16 h then the solids were filtered out and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography eluting with EtOAc/petroleum ether (1:20 up to 1: 1) affording 3.8 g (82%) of the title compound as a white solid. Mass Spectrum (LCMS, ESI pos): Calcd. for Ci4Hi2BrF3N302+: 390.0 (M+H); Found: 390.0., 51355-94-3

The synthetic route of 51355-94-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROTEOSTASIS THERAPEUTICS, INC.; PARKS, Daniel; MUNOZ, Benito; (66 pag.)WO2018/81378; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

51355-94-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51355-94-3,6-Bromopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

6-Bromopyridazin-3(2h)-one (0.57 mmol), triphenylphosphine (1.14 mmol), and di-tert-butyl azodicarboxylate (0.855 mmol) were placed in a vial and dissolved in dichloromethane. N,N-dimethylethanolamine (0.684 mmol) was added at once. After stirring overnight, the reaction was concentrated. The residue was purified by ISCO silica flash chromatography using a dichloromethane:methanol solvent system. The desired product eluted at 8% methanol. Fractions containing the desired product were concentrated to give 6-bromo-2-(2-(dimethylamino)ethyl)pyridazin-3(2H)-one as a white solid (60 mg, 42%).

As the paragraph descriping shows that 51355-94-3 is playing an increasingly important role.

Reference£º
Patent; OHIO STATE INNOVATION FOUNDATION; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; HODGETTS, Kevin; LIN, Chien-Liang, Glenn; (0 pag.)WO2019/236625; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem