Category: 51149-08-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

51149-08-7, Production Example 16 (1) [0971] A mixture of 693 mg of N2-methyl-5-trifluoromethylpyridine-2,3-diamine, 700 mg of 3,6-dichloropyridazine-carboxylic acid, 1.04 g of EDCI hydrochloride, 50 mg of HOBt and 2.5 ml of pyridine was stirred at room temperature for 4 hours and then allowed to stand at room temperature overnight. Water was poured to the reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.19 g of 3, 6-dichloropyridazine-4-carboxylic acid (2-methylamlno-5-trifluoromethylpyridin-3-yl)-amide. 3,6-Dichloropyridazine-4-carboxylic acid (2-methylamino-5-trifluoromethylpyridin-3-yl)-amide 1H-NMR (CDCl3) delta: 8.44 (1H, s), 8.01(1H, s), 7.78 (1H, s), 4.99(1H, brs), 3.10(3H, d).

The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company Limited; TAKAHASHI, Masaki; ITO, Mai; NOKURA, Yoshihiko; TANABE, Takamasa; SHIMIZU, Chie; EP2857397; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

3-hydrazino-4-carboxy-6-chloro-pyridazine A mixture of 3,6-dichloro-4-carboxy-pyridazine (20 g; 0.103 mole) and 22 ml of 98% hydrazine hydrate in 200 ml of 50% ethanol was refluxed, under stirring, for one hour. After cooling at 5 C., the solid precipitate was collected, washed with 20 ml of anhydrous ethanol. The solid was suspended in 100 ml of water, the mixture was brought to pH 1-2 with 23% HCl, after cooling at 5 C. the solid was filtered, dried under vacuum at 80 C. to give 18.29 g (93.4%) of the title compound, m.p. 198-201 C. Elemental analysis: found: C, 31.64; H, 2.64; N, 29.32; Cl, 18.53; calculated for C5 H5 ClN4 O2: C, 31.84; H, 2.67; N, 29.71; Cl, 18.80., 51149-08-7

The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Farmitalia Carlo Erba S.p.A.; US4331666; (1982); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

51149-08-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 3,6-dichloro-4-carboxy-pyridazine (7.5 g, 38.9 mmol, Aldrich) in DCM (30 mL) and MeOH (10 mL) cooled to 0 C. was added a solution of (trimethylsilyl)diazomethane (2.0 M in hexane), slowly via pipette, until a persistent yellow color is observed. After addition was complete, the solvents were removed in vacuo. The crude product was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient (10 to 25% EtOAc) to afford 3.89 g (86%) of 116b as a brown oil that solidifies on standing.

The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Roche Palo Alto LLC; US2008/45511; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

51149-08-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of 3,6-dichloropyridazine-4-carboxylic acid (1.00 g, 5.18 mmol), 4-tert-butylaniline (0.92 ml, 5.60 mmol), TBTU (1.75 g, 5.44 mmol), and DIEA (1.80 ml, 10.4 mmol) in 7.5 ml of anhydrous DMF was stirred at RT under N2 overnight. The mixtrue was diluted with H2O, extracted with EtOAc, and the combined organic portions were washed with brine, dried with Na2SO4, filtered, and condensed. The crude compound was purified by flash column chromatography (hexanes/EtOAc/CH2Cl2, 9:0:1 to 7:2:1), to provide the desired compound as a light yellowish solid. MS (ES+): 423.0 (M+H)+. Calc’d for C21H19ClN6O2 – 422.87.

51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; Amgen Inc.; US2003/225106; (2003); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem