Category: 5096-73-1

Chemistry is traditionally divided into organic and inorganic chemistry. SDS of cas: 5096-73-1, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 5096-73-1

Palladium-catalyzed C-2 selective arylation of quinolines

An efficient method for the Pd-catalyzed regioselective C-2 arylation of quinolines is presented. Reactions of various substituted quinolines and unactivated arenes have been conducted under mild conditions. The result shows good product yields of 2-arylquinolines, which are highly useful building blocks for the synthesis of bioactive alkaloid natural products and drug molecules.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2063 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C5H3ClN2O2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 5096-73-1, name is 6-Chloropyridazine-3-carboxylic acid. In an article£¬Which mentioned a new discovery about 5096-73-1

An efficient palladium-catalyzed synthesis of 1-heteroaryl-4-aminopiperidine derivatives from heteroaryl chlorides

An efficient protocol for the synthesis of 1-heteroaryl-4-(N-methyl)aminopiperidines starting from heteroaryl chloride derivatives is described. A broad range of 1-heteroaryl-4-(N-Boc-N-methyl)aminopiperidine derivatives were obtained in good to excellent yields using DavePhos as optimal ligand for Pd-catalyzed Buchwald-Hartwig amination reaction. After a mild and efficient acidolysis the amination products could be obtained successfully.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2074 – PubChem

 

5096-73-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 5096-73-1, Name is 6-Chloropyridazine-3-carboxylic acid,introducing its new discovery.

Imidazolium supported palladium-chloroglycine complex: Recyclable catalyst for Suzuki-Miyaura coupling reactions

1-Glycyl-3-methyl imidazolium chloride-palladium(II) complex [[Gmim]Cl-Pd(II)] was found to be a catalyst for the Suzuki-Miyaura reaction with excellent yields with high turnover number (6.5 ¡Á 102-9.4 ¡Á 102).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2053 – PubChem

 

5096-73-1, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 5096-73-1, molcular formula is C5H3ClN2O2, introducing its new discovery.

PROCESS FOR PRODUCING BIARYL COMPOUND

A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2039 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 5096-73-1, name is 6-Chloropyridazine-3-carboxylic acid, introducing its new discovery. 5096-73-1

Pd/Cu bimetallic co-catalyzed direct 2-arylation of benzoxazole with aryl chloride

An efficient Palladium/Copper bimetallic co-catalyzed direct 2-arylation of benzoxazoles with aryl chlorides is presented. The Pd(OAc)2/CuI/NiXantphos-based catalyst enables the installation of various aryl and heteroaryl groups in good to excellent yields (75?99%). Preliminary mechanism investigation indicates that Pd/Nixantphos complex activates C-Cl bond of aryl chlorides via oxidative addition, and Cu/Nixantphos complex chelates with nitrogen atom to lower the pKa of the 2-H in benzoxazoles.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5096-73-1 is helpful to your research. 5096-73-1

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2076 – PubChem

 

5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 2; Synthesis of 6-CHLOROPYRIDAZINE-3-CARBOXYLIC ACID PENTYLAMIDE; To a mixture of 6-oxo-1,6-dihydropyridazine-3-carboxylic acid monohydrate (3.50 g, 22.1 mmol) in chloroform (110 mL) was added thionyl chloride (8.1 mL, 110 mmol) then catalytic amount of DMF (0.6 mL). The reaction mixture was heated at reflux for 20 hours during this time reaction mixture turn to dark green. After cooling the solvent was removed in vacuo. The crude material was dried under high vacuum for 30 minutes. The residue dissolved in dichloromethane (110 mL) was added dropwise to a solution of amyl amine (3.84 mL, 33.1 mmol) and triethylamine (5.60 mL, 40.2 mmol) at 0 C. The reaction mixture was stirred at room temperature for 2 hours. The organic layer was washed with water, dried over Na2SO4, filtered, and concentrated. The crude material was purified by column chromatography eluting with ethyl acetate:hexane (4:1) to obtain 6-chloropyridazine-3-carboxylic acid methylpentyl amide (4.8 g, 99%). M.p. 98-101 C. 1H NMR (300 MHz, CDCl3) delta 8.28 (d, J=7.2 Hz, 1H), 8.05 (s, br., 1H), 7.68 (d, J=7.2 Hz, 1H), 3.51 (q, J=5.6 Hz, 2H), 1.69-1.63 (m, 2H), 0.90 (t, J=5.6 Hz, 3H). 13C NMR (75 MHz, CDCl3) delta 161.5, 158.9, 151.8, 129.4, 128.1, 39.8, 29.1, 29.1, 22.4, 14.0. MS (ES+) m/z 228 (M+1).

5096-73-1, The synthetic route of 5096-73-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; XENON PHARMACEUTICALS INC.; US2008/207587; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5096-73-1

EXAMPLE 14; 3-(5-Methyl-l,3,4-oxadiazol-2-ylV6-f3-[2-(trifluoromethyl)phenoxylazetidin-l-vUpyridazine; Step 1: iV-Acetyl–chloropyridazine-S-carbohvdrazide; Into a flame-dried 250 mL round-bottom flask equipped with a magnetic stirring bar and under N2 was added beta-chloropyridazine-S-carboxylic acid (10 g, 63.1 mmol) in dichloromethane (150 mL) and DMF (6.10 mL, 79 mmol). The suspension was treated with oxalyl chloride (6.07 mL, 69.4 mmol) and stirred at room temperature for 30 min, becoming a brown biphasic solution. The solvents were removed under evaporation and the residue taken up in dichloromethane (150 mL) and acetic hydrazine (5.61 g, 76 mmol) and N,N- diisopropylethylamine (22.03 mL, 126 mmol) were added and the solution stirred at room temperature for 4 h. The mixture was cooled, concentrated and poured into a 500 mL separatory funnel containing pH 5 buffer (250 mL) and the mixture was extracted with ethyl acetate (3 x 100 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and the solvent was evaporated under reduced pressure to give a purple solid.

The synthetic route of 5096-73-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/143823; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

5096-73-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5096-73-1,6-Chloropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 4 2-[6-((1R,2R)-1-Benzyl-2-carboxy-2-hydroxy-ethylcarbamoyl)-pyridazin-3-yl]-benzoic Acid (R1=-OH; R41=H) 6-Chloropyridazine-3-carboxylic acid (78.9 mg, 497 mumol, 1.0 eq.), DIPEA (273 muL, 3.2 eq.), HATU (189 mg, 497 mumol, 1.0 eq.), and (2R,3R)-3-amino-2-hydroxy-4-phenyl-butyric acid ethyl ester (129 mg, 497 mumol, 1.0 eq.) were combined in DCM (2 mL) and stirred for 1 hour. The crude reaction was chromatographed using a gradient (0-80% EtOAc/Hex) to obtain (2R,3R)-3-[(6-chloro-pyridazine-3-carbonyl)-amino]-2-hydroxy-4-phenyl-butyric acid ethyl ester.

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Reference£º
Patent; THERAVANCE, INC.; US2012/309724; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5096-73-1,6-Chloropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.

5096-73-1, Step 1:A solution of carbonyldiimidazole (CDI, 165 ??, 1.0 M in N,N-dimethylformamide, 0.165 mmol) was added to a solution of 3-chloropyridazine-6-carboxylic acid (300 ??,, 0.5 M in N,N-dimethylformamide, 0.15 mmol) in a vial. The mixture was shaken at room temperature for 2 hours. A solution of the relevant amine (300 ??, 0.5 M in N,N-dimethylformamide, 0.15 mmol) was added and the vials shaken at room temperature for 20 hours. The reaction was evaporated to dryness under vacuum. The residue was partitioned between ethyl acetate (2.5 mL) and water (2 mL). The layers were separated and the organic layer was evaporated and the residue used without further purification in the subsequent step.

The synthetic route of 5096-73-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER LIMITED; Gibson, Karl Richard; Owen, Dafydd Rhys; WO2013/61297; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5096-73-1,6-Chloropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.,5096-73-1

Step 2: Methyl 6-chlorop yridazine-3 -carboxylate; To a suspension of -chloropyridazine-S-carboxylic acid (4.2 g, 26.5 mmol) in a mixture of toluene (100 mL) and DMF (2.5 mL, 31.8 mmol) was added oxalyl chloride (3.0 mL, 34 mmol). The mixture was stirred at room temperature for 1 h, and then concentrated to an oil. The oil was dissolved in dichloromethane (100 mL) and cooled to 0 C in an ice bath. To this solution was added methanol (20 mL) portionwise, maintaining the temperature of the reaction mixture below 10 C. After 1 h, the mixture was concentrated, and the resulting solid was suspended in diethyl ether and filtered. The solid was triturated with ethyl acetate and diethyl ether and the filtrate was evaporated to provide the title compound as a beige solid.

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Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/143823; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem