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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 5096-73-1, name is 6-Chloropyridazine-3-carboxylic acid, introducing its new discovery. Related Products of 5096-73-1

A reduction of quinolines to synthetically versatile tetrahydroquinoline molecules with I2 and HBpin is described. In the presence of iodine (20 mol%) as a catalyst, reduction of quinolines and other N-heteroarenes proceeded readily with hydroboranes as the reducing reagents. The broad functional-group tolerance, good yields and mild reaction conditions imply high practical utility.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2072 – PubChem

 

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Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are directly involved in the design, creation and manufacturing process of chemical products and materials. Quality Control of 6-Chloropyridazine-3-carboxylic acid

Decarboxylative chlorination of various aromatic and aliphatic carboxylic acids is performed successfully by the photolysis of their benzophenone oxime esters in carbon tetrachloride and corresponding chloro compounds are prepared in good yields.High selective generation of the certain radical and efficiency of the stable radical precursor, benzophenone oxime ester, afford much advantage for radical chemistry.

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The invention discloses a 1, 2, 3, 4 – tetrahydroquinoline compound synthesis method, organic chemical synthesis technology field. The method in order to elemental iodine is the catalyst, borane as reducing agent, quinoline compound used for the catalytic reduction reaction. Compared with the prior synthesis method, the method of the invention the greatest characteristic is the use of inexpensive I2 As the catalyst, without the need of metal involved in the reaction, mild reaction conditions, high speed and high efficiency, high catalytic efficiency, simple operation, good selectivity, the conversion of the product is high, up to 80% or more, popularization and application value, and is favorable for industrial production. (by machine translation)

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Reference:
Pyridazine – Wikipedia,
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Electric Literature of 5096-73-1, The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research.

The induction of micronucleated liver cells (MN-liver cell) was examined with halogenated and hydroxylated quinolines using partially hepatectomized mice. Among the chloroquinolines, 8-chloroquinoline demonstrated a significantly higher level of induction than the control. All the fluorinated derivatives examined, except for 6-fluoroquinoline, induced significantly higher levels, and there were no appreciable differences in MN-liver cell induction among the fluorinated quinolines, regardless of their mutagenic potencies in the Ames test. Of the hydroxylated quinolines examined, 2- and 4-isomers, which are not mutagenic, induced MN-liver cells to the same extent as a mutagenic isomer, 8-hydroxyquinoline. It seems that clastogenicity was not satisfactorily correlated with mutagenicity in the Ames test as far as this class of compounds is concerned.

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Reference:
Pyridazine – Wikipedia,
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We report a simple and efficient visible-light-induced transition-metal-free hydrogenation of aryl halides. The combined visible light and base system is used to initiate the desired radical-mediated hydrogenation. A variety of aryl fluorides, chlorides, bromides, and iodides could be reduced to the corresponding (hetero)arenes with excellent yields under mild conditions. Various functional groups and other heterocyclic compounds are tolerated.

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A highly regioselective Ni-catalyzed electrochemical reductive relay cross-coupling between an aryl halide and an alkyl halide has been developed in an undivided cell. Various functional groups are tolerated under these mild reaction conditions, which provides an alternative approach for the synthesis of 1,1-diarylalkanes.

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This invention relates to novel 3,9-diazabicyclo[3.3.1 ]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

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Indole (1), 5-methoxyindole (1c) and their N-substituted derivatives undergo self-addition to afford indolylindoline derivatives 2a-e and trimers 4a-e in fairly good yield in the presence of catalytic amount (20 mol%) of anhyd indium trichloride.

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5096-73-1, Name is 6-Chloropyridazine-3-carboxylic acid, belongs to pyridazine compound, is a common compound. SDS of cas: 5096-73-1In an article, once mentioned the new application about 5096-73-1.

Treatment of electron deficient pyridine N-oxides with 4-nitrobenzoyl chloride and a cyclic thioether in the presence of triethylamine leads to the corresponding 2-functionalized product in up to a 74% isolated yield. The transformation can also be accomplished with alternative nitrogen containing heterocycles, including quinolines, pyrimidines, and pyrazines. To expand the scope of the transformation, diisopropyl ether can be used as the reaction medium to allow for the use of solid thioether substrates.

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We designed and synthesized a series of 2-Ar-8-methyl-5- alkylaminolquinolines as potent corticotropin-releasing factor 1 (CRF 1) receptor antagonists. The structure-activity relationships of substituents at each position (R3, R5, R 5?, and R8) was investigated. By derivatization, three compounds (6, 14b, and 14c) were identified as orally active CRF 1 receptor antagonists.

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