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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 1-(Pyridazin-4-yl)ethanone, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 50901-46-7, Name is 1-(Pyridazin-4-yl)ethanone, molecular formula is C6H6N2O

Various novel thiosemicarbazones (TSCs) 15b-e, 16b-e, 17b-e, 18b-e, and 19b-e derived from 4-pyridazinecarbaldehyde, 3-pyridazinecarbaldehyde, 4-acetylpyridazine, 3-acetylpyridazine, and 3-propionylpyridazine were prepared and their cytotoxic and antiherpetic potentials were evaluated. It was found that the replacement of the 2-pyridyl-moiety in aldehyde derived compounds 20a-c by a 4-pyridazinyl group (compounds 15b-d) abolishes biological activity. However, in TSCs derived from 3-pyridazinecarbaldehyde (16b-d) the cytotoxic potency was considerably reduced (factor ~300), while the antiviral activity was largely retained. A total loss of biological activity occurred when the pyridyl group in TSC 20d, derived from 2-acetylpyridine, was replaced by the 4-pyridazinyl system (17d). By employment of the 3-pyridazinyl unit for isosteric modification, however, the cell toxicity could be reduced significantly (factor 100) without impairing the antiherpetic potential also in the series of TSCs derived from N-heteroaromatic ketones. It was observed that there is no obvious influence of the size of the cycloamino substituent on the biological activities in compounds 20a-d, 15b-d, 16b-d, 17b-d, and 18b-d. While the pyridine derived TSCs in our experiments proved clearly cytotoxic at lower concentrations than those being antivirally active, the aza-analogous compounds derived from 3-acetyl-pyridazine (18b-e) inhibited plaque formation at concentrations equal to those causing cytotoxic effects. The TSCs 16b-e derived from 3-pyridazinecarbaldehyde were found to show selective antiviral activity against HSV-1. In addition, a significant improvement of the water solubility of heteroaromatic TSCs could be achieved by the replacement of the CH-moiety in position 6 of the pyridine derivatives 20a-c by a nitrogen atom (compounds 16b-d).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N444 – PubChem

 

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Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through refinement of the low energy ligand conformation and mitigation of high in vivo clearance. An in vitro hepatotoxicity hazard was identified and resolved through optimization of lipophilicity and lipophilic ligand efficiency to arrive at GNE-616 (24), a highly potent, metabolically stable, subtype selective inhibitor of Nav1.7. Compound 24 showed a robust PK/PD response in a Nav1.7-dependent mouse model, and site-directed mutagenesis was used to identify residues critical for the isoform selectivity profile of 24.

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Reactions of 3-pyridazinecarbaldehyde and 3-pyridazinecarbaldehyde with various active methylene carbanions were studied.The products obtained in Knoevenagel reactions, Wittig-Horner-Emmons reactions, and Hantzsch-type reactions are presented.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N443 – PubChem

 

Related Products of 50901-46-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.50901-46-7, Name is 1-(Pyridazin-4-yl)ethanone, molecular formula is C6H6N2O. In a article，once mentioned of 50901-46-7

We previously reported the structure-activity relationships (SAR) of adibendan (1), a potent and long-acting cardiotonic.This paper describes the synthesis of a novel series of linear, tricyclic fused heterocycles of the 5-6-5 type.The compounds were evaluated for positive inotropic activity in anesthetized rats, cats, and dogs.Changes in left ventricular dP/dt were measured as an index of cardiac contractility.The increase in contractility was not mediated via stimulation of beta-adrenergic receptors.The data revealed the intrinsic positive inotropic activity of the parent compound of this series, 5,7-dihydro-7,7-dimethylpyrrolo<2,3-f>benzimidazol-6(1H)-one (2).The structural features that impart optimal inotropic activity are presented and compared with those of the 4,5-dihydro-3(2H)-pyridazinone series.The most potent compounds were evaluated orally in conscious dogs with implanted Konigsberg pressure transducers to measure ventricular pressures, and their effect on left ventricular dP/dt was compared with that of 1, pimobendan, and indolidan.After administration of 1 mg/kg, 1, 3, 7, 19, 22, 24, 31, 54, pimobendan, and indolidan were equipotent, but only with 1, 31, pimobendan, and indolidan, durations of action exceeded 6 h.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N448 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C6H6N2O, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 50901-46-7

ACIDIFYING EFFECTS OF AZA GROUPS IN THE NH ACIDITY OF AMINOAZINES AND THE CH ACIDITY OF ACETYLAZINES

The pK values for a series of aminoazines and acetylazines containing one, two, or three aza groups in the ring were determined in dimethyl sulfoxide.There is a good linear correlation between pK values of the investigated NH and CH acids.The acidifying effects (DeltapK) of the aza groups at positions 2, 3, or 4 in relation to the side chain were determined and had values of 3.1, 2.4, and 4.5 logarithmic units in the aminoazines and 3.5, 2.9 and 4.8 logarithmic units respectively in the acetylazines.Except in the case of two ortho-located aza groups the effects are additive.Compared with dimethyl sulfoxide water has a differentiating effect on the acidity of the aminoazines, and this is explained by the formation of hydrogen bonds between the molecules of the proton-donating solvent and the aza groups of the anions of the aminoazines.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N449 – PubChem

 

Synthetic Route of 50901-46-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.50901-46-7, Name is 1-(Pyridazin-4-yl)ethanone, molecular formula is C6H6N2O. In a Patent，once mentioned of 50901-46-7

HERBICIDAL COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as herbicides.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N440 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Quality Control of 1-(Pyridazin-4-yl)ethanone, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 50901-46-7, name is 1-(Pyridazin-4-yl)ethanone. In an article，Which mentioned a new discovery about 50901-46-7

MANIFESTATION OF AZA-EFFECT IN 13C NMR SPECTRA OF ACETYLDIAZINES

Carbon magnetic resonance spectra are reported for isomeric acetyldiazines, and an analysis is made of the changes in chemical shifts of the acetyl-group and ring carbon atoms due to the aza-effect in the isomers. In the alpha-acetylazine series, special features of spectral properties have been revealed for 2-acetylpyrimidines.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N447 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 50901-46-7, name is 1-(Pyridazin-4-yl)ethanone, introducing its new discovery. Formula: C6H6N2O

Nonsteroidal cardiotonics. 3. New 4,5-dihydro-6-(1H-indol-5-yl)pyridazine-3(2H)-ones and related compounds with positive inotropic activities

A sereis of substituted indolyldihydropyridazinones and related compounds 1-18 were synthesized and evaluated for positive inotropic activity. In rats, most of these indole derivatives produced a dose-related increase in myocardial contractility with little effect on heart rate and blood pressure. Compound 13, 4,5-dihydro-5-methyl-6-(2-pyridin-4-yl-1H-indol-5-yl)pyrazine-3(2H)- one (BM 50.0430), was further investigated in cats. The increase in contractility in this animal model was not mediated via stimulation of beta-adrenergic receptors. After oral administration of 1 mg/kg to conscious dogs, compound 13 and pimobendan were still active after 6.5 h. However, the cardiotonic effect of 13 was at least 2-fold that of pimobendan after this period of time. The structural requirements necessary for optimal cardiotonic activity within this novel class of indole derivatives are a heterocyclic aromatic ring in position 2, a hydrogen or a methyl group in position 3, and a dihydropyridazinone ring system in position 5 of the indole.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N446 – PubChem

 

Electric Literature of 50901-46-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.50901-46-7, Name is 1-(Pyridazin-4-yl)ethanone, molecular formula is C6H6N2O. In a Patent£¬once mentioned of 50901-46-7

A terpyridyl derivatives, preparation method and its in the organic electroluminescent device in the application of the (by machine translation)

The present invention provides terpyridyl derivatives with high fluorescence quantum yield, with heat-activated delay fluorescent nature, can be used for the organic light-emitting device material, can especially be used for the non-doped phosphor. As a non-doped phosphor composed of organic electroluminescent device has a low driving voltage, low efficiency roll-off and high efficiency and the like. Therefore, terpyridyl derivatives of the present invention can be used as can be driven with a low voltage, high efficiency, low efficiency roll-off of the organic electroluminescent device components. (by machine translation)

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Pyridazine – Wikipedia,
Pyridazine | C4H4N442 – PubChem

 

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PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS

Novel pyridazinone compounds of formula (I), which inhibit the purinergic P2X7 receptor and are useful for prevention, therapy and improvement of inflammatory and immunological diseases.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N441 – PubChem