With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50681-26-0,6-Chloro-3-hydroxypyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
50681-26-0, 6-chloro-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid (2.0 g, 11.2 mmol) is taken up in MeOH (20 mL), combined with cone. H2SO4 (2 mL) and heated to boiling for 3 h. The reaction solution is combined with H2O, extracted with DCM, washed with NaCl-sln., dried on MgSO4, the solvent is removed and methyl carboxylate B.l-lf (HPLC-MS: tRet. = 1.47 min; MS(M+H)+ = 189; method AFEC) is obtained.
50681-26-0 6-Chloro-3-hydroxypyridazine-4-carboxylic acid 334015, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; McCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7114; (2010); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem