Category: 50681-25-9

Chemistry, like all the natural sciences, Safety of 4-Pyridazinecarboxylic Acid, begins with the direct observation of nature¡ª in this case, of matter.50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, belongs to pyridazines compound. In a document, author is Bin Rus, Yahdi, introduce the new discover.

Electrodeposition of Silver Nanoparticles on Reduced Graphene Functionalized by Pyridine-Pyridazine Units: Application to Surface-Enhanced Raman Spectroscopy and Electrocatalysis

A new and versatile method to prepare Ag nanoparticles on functionalized graphene sheets is described. In a first step, pyridine-pyridazine units are introduced on graphene sheets by cycloaddition reaction with a tetrazine derivative. Then the material is coated on an electrode and electrodeposition is carried out to generate silver nanoparticles in a one-step electroreduction process. The applied potential signal is shown to influence the size and dispersity of the particles in the composite. While larger particles are active in improving sensitivity of Surface-Enhanced Raman Spectroscopy, smaller ones can be efficiently used in electrocatalysis, like for oxygen reduction. Both effects are demonstrated to highlight the versatility of the applications of these easily prepared nanocomposites.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 50681-25-9. Safety of 4-Pyridazinecarboxylic Acid.

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Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Application In Synthesis of 4-Pyridazinecarboxylic Acid, 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, in an article , author is Park, Yong Dae, once mentioned of 50681-25-9.

A Pyridazine-Based Fluorescent Probe Targeting A beta Plaques in Alzheimer’s Disease

Accumulation of beta-amyloid (A beta) plaques comprising A beta 40 and A beta 42 in the brain is the most significant factor in the pathogenesis of Alzheimer’s disease (AD). Thus, the detection of A beta plaques has increasingly attracted interest in the context of AD diagnosis. In the present study, a fluorescent pyridazine-based dye that can detect and image A beta plaques was designed and synthesized, and its optical properties in the presence of A beta aggregates were evaluated. An approximately 34-fold increase in emission intensity was exhibited by the fluorescent probe after binding with A beta aggregates, for which it showed high affinity (K-D=0.35 mu M). Moreover, the reasonable hydrophobic properties of the probe (log P=2.94) allow it to penetrate the blood brain barrier (BBB). In addition, the pyridazine-based probe was used in the histological costaining of transgenic mouse (APP/PS1) brain sections to validate the selective binding of the probe to A beta plaques.) The results suggest that the pyridazine-based compound has the potential to serve as a fluorescent probe for the diagnosis of AD.

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Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Liu, Jiao-Li, once mentioned the application of 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, molecular formula is C5H4N2O2, molecular weight is 124.1, MDL number is MFCD00011576, category is pyridazines. Now introduce a scientific discovery about this category, SDS of cas: 50681-25-9.

Chemiluminescence imaging of UVA induced reactive oxygen species in mouse skin using L-012 as a probe

Reactive oxygen species (ROS) caused by ultraviolet A (UVA) can be reduced by treating with antioxidants and photoprotective reagents. Here we reported a real-time chemiluminescence (CL) imaging method which was simple, non-invasive and sensitive to evaluate UVA-induced ROS generation and the efficacy of sunscreens and antioxidants in vivo. The in vitro experiments indicated that l-ascorbic acid, live SPSC01 yeast, and its intracellular metabolites can suppress the intensity of CL signals in the presence of hydrogen peroxide, which proved the good antioxidant ability of them. Meanwhile, we used 8-amino-5-chloro-7-phenylpyrido[3,4-d] pyridazine-1,4(2H,3H) dione (L-012) as a high sensitive CL probe for in vivo imaging of ROS generated by UVA irradiation. The CL intensity was reduced after treated with l-ascorbic acid and SPSC01 yeast intracellular metabolites, consistent with the in vitro results. Additionally, the in vivo protective capability of two azobenzene compounds as sunscreens was confirmed further through the suppression of CL signals of UVA-induced ROS in mouse skin by this method.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, molecular formula is C5H4N2O2. In an article, author is Liu, Y. Q.,once mentioned of 50681-25-9, Product Details of 50681-25-9.

A Water Soluble Zinc(II) Coordination Polymer Containing Pyridazine-4,5-Dicarboxylic Acid: The Crystal Structure and Binding Properties with DNA

New water soluble complex [Zn(HPDDA)(2)(H2O)(2)(4,4′-Bipy)(2)] (n) (I), where H(2)PDDA is pyridazine- 4,5-dicarboxylic acid, 4,4′-Bipy = 4,4′-bipyridine), has been prepared by hydrothermal reaction and structurally characterized by X-ray single-crystal diffraction analysis (CIF file CCDC no. 835525 ) and elemental analysis. In I, each Zn2+ ion is six-coordinated by two oxygen atoms from the two HPDDA ligands, two nitrogen atoms from two 4,4′-Bipy and two oxygen atoms from two water molecules. The interactions of I with calf thymus DNA were studied by circular dichroism spectroscopy. The results indicated that this water soluble zinc complex show moderate binding with DNA and could be used for candidate for therapy of cancer.

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Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, molecular formula is C5H4N2O2. In an article, author is Yengoyan, Aleksandr P.,once mentioned of 50681-25-9, SDS of cas: 50681-25-9.

Synthesis and Preliminary Biological Properties Assessment of Novel 2-S-, 4, 5-Substituted and Bicyclic Derivatives of 6-Methylpyrimidine-4-ol

A series of novel 2-S-, 4-, 5-substituted and bicyclic 6-methylpyrimidine-4-ol derivatives including pyrazole, 1,2,4-triazole and pyridazine moieties in the molecule were synthesized by accessible and efficient methods. Thiopyrazolyl derivatives were obtained from 2-mercapto-6-methylpyrimidin-4-ol. 4-Triazolyl and 4-aminotriazolylpyrimidines were synthesized from the quaternary ammonium salt of pyrimidine and 4-chloro-substituted 2-thiomethyl-6-methylpyrimidine, respectively. The reaction of potassium salt of 1-methyl-6-oxo-1,6-dihydropyridazin-3-ole with ethyl 2-chloro-3-oxobutanoate and subsequent treatment with thiourea led to 6-((4-hydroxy-2-mercapto-6-methylpyrimidin-5-yl)oxy)-2-methylpyridazin-3 (2H)-one. The reaction product of the latter with 3-chloropentan-2,4-dione was subjected to heterocyclization, which afforded the target bicyclic derivative of pyrimidine. The synthesized compounds showed a pronounced stimulating action on plants growth. Their growth stimulant activities were in the range of 60-93% compared to heteroauxin.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Application of 50681-25-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, belongs to pyridazines compound. In a article, author is Fan, Mingxuan, introduce new discover of the category.

Pyridazine-Containing Diazatwistanthracene and Tetraazatwisttetracene: Synthesis, Crystal Structures and Third Order Non-linear Optical Properties

In this paper, two pyridazine-heterocycles-containing azaacenes 9,12-diphenylphenanthro[4,5-fgh]phthalazine (DPPA) and 2,9-di-tert-butyl-4,7,11,14-tetraphenylpyridazino[4′,5′:9,10] phenanthro[4,5-fgh]phthalazine (TPPA) have been synthesized and fully characterized. The single crystal analysis of TPPA showed that TPPA molecule exhibits a twisted structure with the dihedral angel of 27 degrees between pyrene and pyridazine unit, which suppresses the pi-pi stackings in the solid state. The two-photon absorption properties of DPPA and TPPA were investigated, respectively, by using the femtosecond Z-scan technique. The results showed that both DPPA and TPPA showed moderate two-photon absorption cross-section values, and the larger one was found to be 454 GM with TPPA. Obviously, the introduction of pyridazine ring into the skeleton of acenes forming a A-D-A structure could lead to a much larger two-photon absorption coefficient and two-photon absorption cross section.

Application of 50681-25-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 50681-25-9 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 50681-25-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, belongs to pyridazines compound. In a article, author is Flaig, Kim S., introduce new discover of the category.

Generation of Annelated Dicarbenes and Their Alkali-Metal Chelate Complexes in Solution: Equilibrium between Hetero- and Homoleptic NHC Lithium Complexes

Attempts to generate the free bis(N-heterocyclic carbene) vegi(R) (R = nPr, tBu; vegi(R) = 2,L7-dihydro-2,7-dialkyldiimidazo[1,5-b:5′,1′-f]pyridazine-1,8-diylidene) from its imidazolium salts 1 with alkali-metal bases resulted exclusively in the formation of the respective lithium, sodium, and potassium complexes 2-4 due to the strongly chelating properties of the dicarbene. DFT calculations reveal pronounced dispersion interactions in the case of N-tertbutyl substituents as the reason for the formation of the homoleptic lithium species 2b-H in solution. The dynamic behavior of the lithium complexes in equilibrium was studied by NMR techniques. Attempts to liberate the free carbenes by addition of the respective crown ethers failed for the lithium and sodium complexes. Deprotonation of the imidazolium salts 1a,b with the strong metal-free phosphazene base P4-tBu ({(Me2N)(3)PN}(3)PNtBu) generated successfully the free dicarbenes vegi(R) (5) and monocarbene 6b in solution.

Reference of 50681-25-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 50681-25-9.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Banerjee, Paramita, once mentioned the application of 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, molecular formula is C5H4N2O2, molecular weight is 124.1, MDL number is MFCD00011576, category is pyridazines. Now introduce a scientific discovery about this category, Application In Synthesis of 4-Pyridazinecarboxylic Acid.

Substituent effects at nitrogen/phosphorus atoms of dialkaline earth metal complexes: Excess electron and large second-hyperpolarizability

A number of imido-, amido-, and phosphido-bridged dialkaline earth metal (M = Be, Mg, and Ca) complexes and their alkali metal (Li and Na) derivatives have been considered to study the ground state structure and the second-hyperpolarizability. The calculated ground state geometries contain four-membered M-N(P)-M-N(P) ring having either planar or butterfly-like bent structure. The second-hyperpolarizability has been calculated at the HF and CCSD(T) levels using Sadlej’s pol and aug-pc-2 basis sets, respectively. The addition of second hydrogen/alkali metal atom on nitrogen/phosphorus (N/P) atom substantially reduces the charge transfer from the alkaline earth metal atoms as the high negative charge on N/P exerts stronger push effect on the outermost electron pair in the ns sub-shell of M. The excess electron density on the alkaline earth metal atoms plays a crucial role in the enhancement of second-hyperpolarizability. The sum-over-state method calculated two-photon contribution of second-hyperpolarizability has been found to be significant. The variation of second-hyperpolarizability has been explained satisfactorily in terms of the TD-CAMB3LYP calculated spectroscopic properties in the light of two-state model. The calculated mean second-hyperpolarizabilities of alkali substituted amido- and phosphido-bridged complexes are in the order of 10(7) au.

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Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry, like all the natural sciences, Quality Control of 4-Pyridazinecarboxylic Acid, begins with the direct observation of nature¡ª in this case, of matter.50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, belongs to pyridazines compound. In a document, author is Elissawy, Ahmed M., introduce the new discover.

New secondary metabolites from the mangrove-derived fungus Aspergillus sp. AV-2

Chemical investigation of the mangrove-derived fungus Aspergillus sp. AV-2 following fermentation on solid rice medium led to the isolation of a new phenyl pyridazine derivative (1) and a new prenylated benzaldehyde derivative, dioxoauroglaucin (2), together with fourteen known compounds (3-16). Chemical structures of the new compounds were unambiguously determined based on HRESIMS and extensive 1D and 2D NMR spectroscopic analyses. Compounds 2-7, 8 and 13 were assessed for their antiproliferative activity against Caco-2 cell lines, where flavoglaucin (6) revealed the most potent cytotoxicity with IC50 of 2.87 mu M.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 50681-25-9. Quality Control of 4-Pyridazinecarboxylic Acid.

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Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is an experimental science, Name: 4-Pyridazinecarboxylic Acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, molecular formula is C5H4N2O2, belongs to pyridazines compound. In a document, author is Shah, Shaheen.

Quantum chemical investigation on photodegradation mechanisms of sulfamethoxypyridazine with dissolved inorganic matter and hydroxyl radical

Sulfamethoxypyridazine (SMP) is one of the commonly used sulfonamide antibiotics (SAs). SAs are mainly studied to undergo triplet-sensitized photodegradation in water under natural sunlight with other coexisting aquatic environmental organic pollutants. In this work, SMP was selected as a representative of SAs. We studied the mechanisms of triplet-sensitized photodegradation of SMP and the influence of selected dissolved inorganic matter, i.e., anions (Br-, Cl-, and NO3-) and cations ions (Ca2+, mg(2+), and Zn2+) on SMP photodegradation mechanism by quantum chemical methods. In addition, the degradation mechanisms of SMP by hydroxyl radical (OH center dot) were also investigated. The creation of SO2 extrusion product was accessed with two different energy pathways (pathway-1 and pathway-2) by following two steps (step-I and step-II) in the triplet sensitized photodegradation of SMP. Due to low activation energy, the pathway-1 was considered as the main pathway to obtain SO2 extrusion product. Step-II of pathway-1 was measured to be the rate-limiting step (RLS) of SMP photodegradation mechanism and the effect of the selected anions and cations was estimated for this step. All selected anions and cations promoted photodegradation of SMP by dropping the activation energy of pathway-1. The estimated low activation energies of different degradation pathways of SMP with OH center dot radical indicate that OH center dot radical is a very powerful oxidizing agent for SMP degradation via attack through benzene derivative and pyridazine derivative ring. (C) 2016 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 50681-25-9. Name: 4-Pyridazinecarboxylic Acid.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem