Category: 504-30-3

504-30-3, Pyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 40A tert-butyl 4-(6-oxo-1(6H)-pyridazinyl)-1-piperidinecarboxylate tert-Butyl 4-bromo-1-piperidinecarboxylate (1.00 g, 3.78 mmol) in DMF (20 mL) was treated with K2CO3 (523 mg, 3.78 mmol) and 3(2H)-pyridazinone (340 mg, 3.78 mmol) and then heated at 45 C. for 60 hours. The reaction mixture was allowed to cool to room temperature, poured into water (80 mL) and extracted with ethyl acetate (80 mL). The organic layer was washed with brine (3*50 mL), dried over MgSO4, filtered, and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (elution with hexanes:ethyl acetate, 3:1) to provide the title compound (180 mg, 17% yield). 1H NMR (300 MHz, DMSO-d6) delta1.41 (s, 9H), 1.66 (m, 4H), 2.91 (m, 2H), 4.05 (m, 2H), 4.96 (m, 1H), 6.93 (dd, 1H, J=1.5, 9.0 Hz), 7.39 (dd, 1H, J=3.0, 9.0 Hz), 7.95 (dd, 1H, J=3.0, 9.0 Hz); (MS (DCI/NH3) m/e 280 (M+H)+., 504-30-3

As the paragraph descriping shows that 504-30-3 is playing an increasingly important role.

Reference£º
Patent; Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.; US2004/29887; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

504-30-3, Pyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17; 2-f4-((1R.2R)-2-ir(2SV2-MethylPyrrolidin-1-vnmethyl)cvclopropyhphenvnpyridazin-; A solution of the product from Example 4A (47 mg, 0.16 mmol;1-[2-(4- bromo-phenyl)-(1 R, 2R)-cyclopropylmethyl]-(2S)-2-methyl-pyrrolidine), 3(2H)- pyridazinone (CAS No. 504-30-3, 20 mg, 0.2 mmol), copper iodide (1.5 mg, 0.008 mmol), N.N’-trans-dimethyl-cyclohexane-i^-diamine (2.3 mg, 0.016 mmol) and potassium phosphate (75 mg, 0.35 mmol) in a mixture of toluene and isopropanol (4 ml, 1:1) was heated to 1100C in a screw capped vial for 16 hours. The mixture was cooled to ambient temperature, treated with H2O and extracted with ethyl acetate (2 x 25 ml_). The organic layer was separated, washed with brine and dried with magnesium sulfate. After filtration, the organic layer was concentrated under reduced pressure and the resulting oil was purified on silica gel with 1 % to 3% methanol (containing 10 % concentrated NH4OH) in dichloromethane to provide the title compound. 1H NMR (300 MHz, CD3OD) delta 1.07 (m. 1H), 1.14 (m, 1H), 1.26 (d, J=6 Hz1 3H), 1.40 (m, 1H), 1.58 (m, 1H), 1.90(m, 3H), 2.13 (m, 1H), 2.58 (m, 1H), 2.70 (q, J=9 Hz, 1H), 2.89 (m, 1H), 3.14 (dd. J=12 Hz, J=6 Hz1 1H), 3.44 (m, 1 H), 7.07 (d, J=9 Hz, 1 H)1 7.24 (d, J=9 Hz1 2H), 7.44 (d, J=9 Hz, 2H), 7.47 (m, 1H), 8.03 (m, 1H). MS (DCI-NH3) m/z 310 (M+H)+., 504-30-3

As the paragraph descriping shows that 504-30-3 is playing an increasingly important role.

Reference£º
Patent; ABBOTT LABORATORIES; WO2007/150010; (2007); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

504-30-3, Pyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of the product from Example 1E (500 mg, 1.87 mmol), 3(2H>pyridazinone (180 mg, 1.87 mmol), copper powder (120 mg, 1.87 mmol), and K2CO3 (775 mg, 5.61 mmol, 3 equiv.) in pyridine (75 ML) was stirred at reflux under a dry nitrogen atmosphere for 20 hr.The reaction mixture was cooled to room temperature then concentrated under reduced pressure.Residual pyridine was removed by repeated evaporation with toluene.The residue was partitioned between ethyl acetate (350 ML) and saturated aqueous Na2CO3.The organic layer was washed twice with aqueous NH4Cl, dried (MgSO4), filtered, and the filtrate was concentrated under reduced pressure.The residue was purified by column chromatography (75:25 ethyl acetate/hexane) to provide the title compound. 1H NMR (CDCl3, 300 MHz) delta 8.11 (d, J=2 Hz, 1H), 7.97-7.93 (m, 1H), 7.88 (t, J=9 Hz, 2H), 7.75-7.68 (m, 2H), 7.41 (dd, J=2, 12 Hz, 1H), 7.31-7.24 (m, 1H), 7.10 (dd, J=2, 12 Hz, 1H), 3.97 (t, J=6 Hz, 2H), 3.06 (t, J=6 Hz, 1H). MS (DCl-NH3) [M+H]+ at 267, [M+NH4]+ at 284., 504-30-3

504-30-3 Pyridazin-3(2H)-one 68153, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Sharma, Padam N.; Bennani, Youssef L.; US2004/92521; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem