Category: 4949-44-4

Reference of 4949-44-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 4949-44-4, Name is Ethyl 3-oxopentanoate, SMILES is CCC(CC(OCC)=O)=O, belongs to pyridazines compound. In a article, author is Lu Qiang, introduce new discover of the category.

Synthesis and Bioactivity of 1-Methyl-3-aryl-6(trifluoromethyl)pyridazin-4(1H)-one Derivatives

A novel series of 3-aryl pyridazinone was proposed on the base of structure activity relationships of diverse protoporphyrinogen oxidase inhibitors. Synthetic method of 3-aryl pyridazinones was investigated and 9 compounds were synthesized for interior screening test of herbicidal activity and crop safety. Bioassay results showed that most of 3-aryl-pyridazinones exhibit excellent pre-orpost-emergence herbicidal activity. Herein, 3-(2,4-dichloro-5-(cyclopentyloxy) phenyl)1-methyl-6-(trifluoromethyl) pyridazin-4(1H)-one(Ie) with high activity was selected as a post-herbicide candidate into corn field trial. The results showed that Ie exhibited higher total effective rate against weeds at the dose of 60 g a. i./hm(2) than mesotrione at 105 g a. i./hm(2), and safety to corn after emergence as well.

Reference of 4949-44-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4949-44-4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4949-44-4, Name is Ethyl 3-oxopentanoate, molecular formula is C7H12O3, belongs to pyridazines compound. In a document, author is Mosberger, Mathias, introduce the new discover, Quality Control of Ethyl 3-oxopentanoate.

Influence of Hetero-Biaryl Ligands on the Photo-Electrochemical Properties of [(ReNCS)-N-I((NN)-N-boolean AND)(CO)(3)]-Type Photosensitizers

A complete set of the symmetrical bidiazine (bdz) and asymmetrical pyridyldiazine (pydz) ligands, along with the known 2,2 ‘-bipyridyl (bpy) ligand, and their respective rhenium(I)-tricarbonyl-bromo and -thiocyonato complexes are presented. A bathochromic shift is observed with an increasing number of nitrogen atoms, caused by a stabilization of the diimine based LUMO. As expected from the energy gap law, this results in an increase in the non-radiative decay constant (k(nr)) along the line bpy-pydz-bdz. Interestingly, the increase in k(nr) for both pyridazine ligands (2-(pyridin-2-yl)pyridazine (pypdz) and 3,3 ‘-bipyridazine (bpdz)) is much less pronounced as compared to the other pydz resp. bdz ligands. This results in overall longer lifetime and quantum yield, at the increased spectral overlap with sunlight – both properties sought for in the creation of light-harvesting schemes in photochemistry.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4949-44-4. Quality Control of Ethyl 3-oxopentanoate.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 4949-44-4, Name is Ethyl 3-oxopentanoate, SMILES is CCC(CC(OCC)=O)=O, in an article , author is Mao, Beibei, once mentioned of 4949-44-4, SDS of cas: 4949-44-4.

Design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine derivatives as mTOR inhibitors

ATP-competitive mTOR inhibitors have been studied as potential antitumor agents. Based on the structure-activity relationship of known mTOR inhibitors, a series of novel imidazo[1,2-b]pyridazine derivatives were synthesized and characterized. The anti-proliferative activities of these compounds were evaluated by SRB assay against six human cancer cell lines. Imidazo[1,2-b]pyridazine diaryl urea derivatives A15-A24 exhibited significant anti-proliferative activity especially against non-small cell lung cancer A549 and H460 with IC50 values ranging from 0.02 mu M to 20.7 mu M. Among them, compounds A17 and A18 showed mTOR inhibitory activity with IC50 of 0.067 mu M and 0.062 mu M, respectively. A more detailed analysis of compounds A17 and A18 showed that they induced G1-phase cell cycle arrest and suppressed the phosphorylation of AKT and S6 at cellular level. Moreover, obvious anticancer effect of A17 in vivo was observed in established nude mice A549 xenograft model. (C) 2017 Elsevier Masson SAS. All rights reserved.

Interested yet? Read on for other articles about 4949-44-4, you can contact me at any time and look forward to more communication. SDS of cas: 4949-44-4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 4949-44-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 4949-44-4, Name is Ethyl 3-oxopentanoate, SMILES is CCC(CC(OCC)=O)=O, belongs to pyridazines compound. In a article, author is Kilic, Burcu, introduce new discover of the category.

Design and synthesis of some new carboxamide and propanamide derivatives bearing phenylpyridazine as a core ring and the investigation of their inhibitory potential on in-vitro acetylcholinesterase and butyrylcholinesterase

A series of new carboxamide and propanamide derivatives bearing phenylpyridazine as a core ring were designed, synthesized and evaluated for their ability to inhibit both cholinesterase enzymes. In addition, a series of carboxamide and propanamide derivatives bearing biphenyl instead of phenylpyridazine were also synthesized to examine the inhibitory effect of pyridazine moiety on both cholinesterase enzymes. The inhibitory activity results revealed that compounds 5b, 5f, 5h, 5j, 5l pyridazine-3-carboxamide derivative, exhibited selective acetylcholinesterase (AChE) inhibition with IC50 values ranging from 0.11 to 2.69 mu M. Among them, compound 5h was the most active one (IC50 = 0.11 mu M) without cytotoxic effect at its effective concentration against AChE. Additionally, pyridazine-3-carboxamide derivative 5d (IC50 for AChE = 0.16 mu M and IC50 for BChE = 9.80 mu M) and biphenyl-4-carboxamide derivative 6d (IC50 for AChE = 0.59 mu M and IC50 for BChE = 1.48 mu M) displayed dual cholinesterase inhibitory activity. Besides, active compounds were also tested for their ability to inhibit A beta aggregation. Theoretical physicochemical properties of the compounds were calculated by using Molinspiration Program as well. The Lineweaver-Burk plot and docking study showed that compound 5 h targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE.

Reference of 4949-44-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4949-44-4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 4949-44-4, Name is Ethyl 3-oxopentanoate, SMILES is CCC(CC(OCC)=O)=O, in an article , author is Katsuma, Yuhei, once mentioned of 4949-44-4, Computed Properties of C7H12O3.

Reactivity of Highly Lewis-Acidic Diborane(4) toward C equivalent to N and N=N Bonds: Uncatalyzed Addition and N=N Bond-Cleavage Reactions

The diboration of the C equivalent to N bond in organic nitriles, and the N=N bond in azobenzene and pyridazine, by the highly Lewis-acidic tetra(o-tolyl)diborane(4) are reported. In the reactions with nitriles, azobenzene, and pyridazine, the addition of diborane(4) to the C equivalent to N and N=N bonds was observed. Conversely, the N=N bond in phthalazine was cleaved by an addition/rearomatization sequence.

Interested yet? Read on for other articles about 4949-44-4, you can contact me at any time and look forward to more communication. Computed Properties of C7H12O3.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 4949-44-4, Name is Ethyl 3-oxopentanoate, SMILES is CCC(CC(OCC)=O)=O, in an article , author is Schnel, Anne, once mentioned of 4949-44-4, Application In Synthesis of Ethyl 3-oxopentanoate.

Mechanistic studies of an L-proline-catalyzed pyridazine formation involving a Diels-Alder reaction with inverse electron demand

The mechanism of an L-proline-catalyzed pyridazine formation from acetone and aryl-substituted tetrazines via a Diels-Alder reaction with inverse electron demand has been studied with NMR and with electrospray ionization mass spectrometry. A catalytic cycle with three intermediates has been proposed. An enamine derived from L-proline and acetone acts as an electron -rich dienophile in a [4 + 2] cycloaddition with the electron-poor tetrazine forming a tetraazabicyclo[2.2.2]octadiene derivative which then eliminates N-2 in a retro-Diels-Alder reaction to yield a 4,5-dihydropyridazine species. The reaction was studied in three variants: unmodified, with a charge-tagged substrate, and with a charge-tagged proline catalyst. The charge -tagging technique strongly increases the ESI response of the respective species and therefore enables to capture otherwise undetected reaction components. With the first two reaction variants, only small intensities of intermediates were found, but the temporal progress of reactants and products could be monitored very well. In experiments with the charge-tagged L-proline-derived catalyst, all three intermediates of the proposed catalytic cycle were detected and characterized by collision -induced dissociation (CID) experiments. Some of the CID pathways of intermediates mimic single steps of the proposed catalytic cycle in the gas phase. Thus, the charge-tagged catalyst proved one more time its superior effectiveness for the detection and study of reactive intermediates at low concentrations.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 4949-44-4, you can contact me at any time and look forward to more communication. Application In Synthesis of Ethyl 3-oxopentanoate.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 4949-44-4, 4949-44-4, Name is Ethyl 3-oxopentanoate, SMILES is CCC(CC(OCC)=O)=O, belongs to pyridazines compound. In a document, author is Adly, Omima M., I, introduce the new discover.

Synthesis, spectroscopic, X-ray diffraction, antimicrobial and antitumor studies of Ni(II) and Co(II) complexes derived from 4-acetyl-5,6-diphenyl-3(2H)-pyridazinone and ethylenediamine

Reactions of the Schiff base ligand derived from 4-acetyl-5,6-diphenyl-3(2H)-pyridazinone and ethyl-enediamine with Ni(II) and Co(II) using different metal salts; NO3, AcO, ClO4 and Cl yielded binary metal complexes. Mixed-ligand complexes were synthesized by using extra ligands including 8-hydroxyquinoline or glycine as nitrogen, oxygen-donors; 1,10-phenanthroline or 2-aminopyridine as nitrogen, nitrogen-donors. Elemental and thermal analyses, spectroscopic techniques (IR, electronic and mass), conductivity and magnetic susceptibility measurements were utilized to characterize the structures of the complexes. Electronic spectra and magnetic moment measurements showed that all complexes are octahedral and tetrahedral. In addition, activation energies of thermal degradation were calculated by means of Coats-Redfern equations. The activation energies were also used to evaluate kinetic and thermodynamic parameter of the metal complexes including Ea, Delta H, Delta S and Delta G. The XRD patterns for the ligand and its metal complexes indicate crystalline nature with nano particle sizes. The biological activity of the chelating agent and its metal complexes was conducted towards S. aureus and B. subtilis as Gram-+ve bacteria, S. typhimurium and E. coli as Grame-ve bacteria, C. albicans (yeast) and A. fumigatus (fungus). The chelating agent and some Ni(II) and Co(II) complexes showed antitumor activity towards HepG2 cell line. (C) 2020 Elsevier B.V. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4949-44-4. Product Details of 4949-44-4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

In an article, author is Ben Aissa, Mohamed Ali, once mentioned the application of 4949-44-4, Formula: C7H12O3, Name is Ethyl 3-oxopentanoate, molecular formula is C7H12O3, molecular weight is 144.17, MDL number is MFCD00009317, category is pyridazines. Now introduce a scientific discovery about this category.

Theoretical Density Functional Theory insights into the nature of chalcogen bonding between CX2 (X = S, Se, Te) and diazine from monomer to supramolecular complexes

Chalcogen bonding is a noncovalent interaction, highly similar to halogen and hydrogen bonding, occurring between a chalcogen atom and a nucleophilic region. Two density functional theory (DFT) approaches B3LY-D3 and B97-D3 were performed on a series of complexes formed between CX2 (X = S, Se, Te) and diazine (pyridazine, pyrimidine and pyrazine). Chalcogen atoms prefer interacting with the lone pair of a nitrogen atom rather than with the pi-cloud of an aromatic ring. CTe2 and CSe2 form a stronger chalcogen bond than CS2. The electrostatic potential of CX2 (X = S, Se and Te) reveals the presence of two equivalent sigma-holes, one on each chalcogen atom. These CX2 molecules interact with diazine giving rise to supramolecular interactions. Wiberg bond index and second-order perturbation theory analysis in NBO were performed to better understand the nature of the chalcogen bond interaction.

If you are interested in 4949-44-4, you can contact me at any time and look forward to more communication. Formula: C7H12O3.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 4949-44-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 4949-44-4, Name is Ethyl 3-oxopentanoate, SMILES is CCC(CC(OCC)=O)=O, belongs to pyridazines compound. In a article, author is Aniskova, Tatyana, introduce new discover of the category.

Synthesis of Compounds of the Pyrimidine Series Based on the Reactions of 3-Arylmethylidenefuran-(3H)-ones with N,N-Binucleophilic Reagents

The arylmethylidene derivatives of furan-2(3H)-ones are important building blocks for the synthesis of various heterocyclic compounds containing pyrimidine and pyridazine structural fragments, analogues of nitrogen-containing bases of pyrimidine series. In order to continue the development of constructing of molecules containing pyridine and pyridazine fragments, this article is devoted to the synthesis of new biologically active compounds with these moieties. The introduction of a heterocyclic chromenone fragment changes the previously observed 5-R-3-arylmethylidenefuran-2(3H)-ones route of reaction with guanidine carbonate and leads to 3-[(2-amino-4-(2-hydroxyphenyl)pyrimidin-5-yl)methylene]-5-phenylfuran-2(3H)-ones (2a-d). The structure of the reaction products depends on the nature of the aromatic substituent at the C-3 position of the furanone ring. The interaction of 5-aryl-3-arylmethylidenefuran-2(3H)-ones (1e-h) with thiourea in the basic medium leads to the isolation of 5-(2-oxo-2-phenylethyl)6-aryl-2-thioxotetrahydropyrimidine-4(1H)-ones (3a-d), demonstrating pronounced plant-growth regulatory activity. Optimal conditions for all discussed processes were developed.

Reference of 4949-44-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 4949-44-4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Product Details of 4949-44-4, 4949-44-4, Name is Ethyl 3-oxopentanoate, SMILES is CCC(CC(OCC)=O)=O, in an article , author is Subramaniam, Jeevithra Dewi, once mentioned of 4949-44-4.

Synthesis and structural characterization of centrosymmetric multinuclear nickel(II) complexes with neutral tetradentate N6-ligand

A neutral tetradentate ligand L1 [L1 = 3,6-bis(pyrazol-1-yl)-pyridazine] reacts with Ni(ClO4)(2)center dot 6H(2)O and undergoes counterion exchange with PF6- to give di- and tetranuclear complexes [Ni-2(L1)(2)(CH3CN)(4)](PF6)(4)center dot 4H(2)O (1) and [Ni-4(L1)(4)(mu-OH)(4)](ClO4)(4)center dot 2H(2)O (2), respectively. The presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base controls the nuclearity of the complex formation. Both complexes were structurally characterized by physicochemical and spectroscopic techniques. Their crystal structures revealed that both complexes are centrosymmetric and adopt slightly distorted octahedral geometry. Complex 1 crystallizes in monoclinic space group C2/c as the Ni(II) center is octahedrally bound to L1 in a trans-isomer arrangement. Complex 2 crystallizes in tetragonal space group I4(1)/amd with four L1 and four hydroxy bridging ligands linked to Ni(II) center in cis-isomer arrangement. Cyclic voltammograms of complexes 1 and 2 were measured under Ar and CO2. Under CO2, the quasireversible peaks of both complexes become irreversible and a current enhancement occurs under reduction.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 4949-44-4, you can contact me at any time and look forward to more communication. Product Details of 4949-44-4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem