Category: 492431-11-5

Electric Literature of 492431-11-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, molecular formula is C13H19ClN4O2. In a article£¬once mentioned of 492431-11-5

Use of small-molecule crystal structures to address solubility in a novel series of g protein coupled receptor 119 agonists: Optimization of a lead and in vivo evaluation

G protein coupled receptor 119 (GPR119) is viewed as an attractive target for the treatment of type 2 diabetes and other elements of the metabolic syndrome. During a program toward discovering agonists of GPR119, we herein describe optimization of an initial lead compound, 2, into a development candidate, 42. A key challenge in this program of work was the insolubility of the lead compound. Small-molecule crystallography was utilized to understand the intermolecular interactions in the solid state and resulted in a switch from an aryl sulphone to a 3-cyanopyridyl motif. The compound was shown to be effective in wild-type but not knockout animals, confirming that the biological effects were due to GPR119 agonism.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 492431-11-5

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3241 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: pyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, molecular formula is C13H19ClN4O2

Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use

The invention relates to compounds of formula: 1 and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopressin V1b receptors and/or for the ocytocin receptors and, furthermore, for certain compounds, affinity for the V1a receptors. The invention also relates to the process for preparing them, to the intermediate compounds of formula (IV) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, category: pyridazine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 492431-11-5

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3228 – PubChem

 

Application of 492431-11-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, molecular formula is C13H19ClN4O2. In a Patent£¬once mentioned of 492431-11-5

Tetrahydroquinoline Derivatives And Their Pharmaceutical Use

Tetrahydroquinoline compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 492431-11-5

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3231 – PubChem

 

Electric Literature of 492431-11-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 492431-11-5, 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, introducing its new discovery.

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3

We describe the structural optimization of a lead compound 1 that exhibits dual inhibitory activities against FLT3 and CDK4. A series of pyrido[4?,3?:4,5]pyrrolo[2,3-d]pyrimidine derivatives was synthesized, and SAR analysis, using cell-based assays, led to the discovery of 28 (AMG 925), a potent and orally bioavailable dual inhibitor of CDK4 and FLT3, including many FLT3 mutants reported to date. Compound 28 inhibits the proliferation of a panel of human tumor cell lines including Colo205 (Rb +) and U937 (FLT3WT) and induced cell death in MOLM13 (FLT3ITD) and even in MOLM13 (FLT3ITD, D835Y), which exhibits resistance to a number of FLT3 inhibitors currently under clinical development. At well-tolerated doses, compound 28 leads to significant growth inhibition of MOLM13 xenografts in nude mice, and the activity correlates with inhibition of STAT5 and Rb phosphorylation.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 492431-11-5. In my other articles, you can also check out more blogs about 492431-11-5

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3239 – PubChem

 

Synthetic Route of 492431-11-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, molecular formula is C13H19ClN4O2. In a Patent£¬once mentioned of 492431-11-5

PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The purpose of the present invention is to provide a compound having an excellent CDK4/6 inhibiting activity. The present invention is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 492431-11-5

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3235 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.492431-11-5,1-Boc-4-(6-Chloropyridazin-3-yl)piperazine,as a common compound, the synthetic route is as follows.

A mixture of tert-butyl 4- (6-chloropyridazin-3-yl)piperazine-l-carboxylate (0.060 g, 0.20 mmol), compound 83 (0.054 g, 0.20 mmol), Xantphos (0.017 g, 0.030 mmol), Pd2(dba)3 (0.014 g, 0.015 mmol), and sodium tert-butoxide (0.029 g, 0.30 mmol) in dioxane was purged with nitrogen gas for 1 minute. The reaction was heated at 12O0C for 6 hours and then cooled to room temperature. The solvent was removed by filtration. The residue was washed with 2 x ImI dioxane. The product was then dissolved in 1OmL methanol/DCM (1 :1) and concentrated. The crude material was re-dissolved in 4mL methanol and purified on a C-18 reversephase column (150 x 30 mm, 4 micro) using Mass directed preperative HPLC and gradient elution of acetonitrile in water containing 0.1%TFA to give the title compound 162. LCMS-ESI (POS), M/Z, M+l: 532.3

492431-11-5, 492431-11-5 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine 21925370, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; AMGEN INC.; WO2009/85185; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

492431-11-5,492431-11-5, 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 10.5 g of the compound obtained in the preceding step and 2.5 g of 10% palladium-on-charcoal in 30 ml of DMF and 250 ml of EtOH is hydrogenated overnight at RT and atmospheric pressure. The catalyst is filtered off and the filtrate is concentrated under vacuum. The residue is chromatographed on silica gel, eluting with a DCM/MeOH mixture of from (97/3; v/v) to (90/10; v/v). 9.1 g of the expected product are obtained, and are used without further purification.

492431-11-5 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine 21925370, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Di Malta, Alain; Garcia, Georges; Roux, Richard; Schoentjes, Bruno; Serradeil-Le Gal, Claudine; Tonnerre, Bernard; Wagnon, Jean; US2004/180878; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

492431-11-5, 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of 6-(Piperazin-1-yl)pyridazin-3(2H)-one 6-4: (1204) A solution of tert-butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate 6-3 (2.2 g, 7.36 mmol) in acetic acid (20mL) was heated at 120 C for 16 h. After complete consumption of Cpd-3 as evident from TLC, the volatiles were stripped off, residue partitioned between ethyl acetate and water, combined organic extracts evaporated to afford a crude residue which was purified over neutral alumina (elution with 30% methanol/DCM)to afford 6-(piperazin-1- yl)pyridazin-3(2H)-one 6-4 (871 mg, 4.83 mmol, 65.9 %) as a brown solid. LC MS: ES+ 181.1

492431-11-5, The synthetic route of 492431-11-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; CHEN, Chi-li; DUPLESSIS, Martin; HE, Minsheng; LAZARSKI, Kiel; (980 pag.)WO2017/197051; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem