Category: 492431-11-5

Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. Reference of 492431-11-5. Introducing a new discovery about 492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine

The purpose of the present invention is to provide a compound that has excellent CDK4/6 inhibitory activity. The present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt of the compound.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3236 – PubChem

 

Related Products of 492431-11-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 492431-11-5, 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, introducing its new discovery.

Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency and selectivity determinants were established based on the X-ray crystallographic analysis of representative compounds bound to monomeric CDK6. Significant selectivity for CDK4/6 over CDK1 and CDK2 was demonstrated with several compounds in both enzymatic and cellular assays.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 492431-11-5. In my other articles, you can also check out more blogs about 492431-11-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3238 – PubChem

 

Reference of 492431-11-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, molecular formula is C13H19ClN4O2. In a Patent，once mentioned of 492431-11-5

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group -OR5; a group -CH2OR5; a group -NR6R7; a group -NR8COR9; a group -NR8CONR10R11; a group -CH2NR12R13; a group -CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group -CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents an aromatic group selected from: the said aromatic groups being unsubstituted or being mono- or disubstituted by a substituent selected independently from a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; Preparation process and therapeutic application.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 492431-11-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3234 – PubChem

 

Reference of 492431-11-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 492431-11-5, 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, introducing its new discovery.

The purpose of the present invention is to provide a compound that has excellent CDK4/6 inhibitory activity. The present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt of the compound.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 492431-11-5. In my other articles, you can also check out more blogs about 492431-11-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3236 – PubChem

 

492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, belongs to pyridazine compound, is a common compound. COA of Formula: C13H19ClN4O2In an article, once mentioned the new application about 492431-11-5.

The present invention provides a compound of formula IA or a pharmaceutically acceptable salt thereof; 5 (IA) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3229 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 492431-11-5

Tetrahydroquinoline compounds of Formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3232 – PubChem

 

492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, belongs to pyridazine compound, is a common compound. Application In Synthesis of 1-Boc-4-(6-Chloropyridazin-3-yl)piperazineIn an article, once mentioned the new application about 492431-11-5.

AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION

This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3237 – PubChem

 

Synthetic Route of 492431-11-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, molecular formula is C13H19ClN4O2. In a Patent，once mentioned of 492431-11-5

FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4 mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3230 – PubChem

 

Synthetic Route of 492431-11-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, molecular formula is C13H19ClN4O2. In a Article£¬once mentioned of 492431-11-5

Optimization of a series of multi-isoform PI3 kinase inhibitors

Optimization of the cellular and pharmacological activity of a novel series of PI3 kinase inhibitors targeting multiple isoforms is described.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 492431-11-5, and how the biochemistry of the body works.Synthetic Route of 492431-11-5

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N3240 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C13H19ClN4O2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 492431-11-5

METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE

Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N3233 – PubChem