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ATG7 INHIBITORS AND THE USES THEREOF

Disclosed are chemical entities which are compounds of formula (I) : or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.

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Related Products of 37444-46-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.37444-46-5, Name is Pyridazin-3-ylmethanol, molecular formula is C5H6N2O. In a Patent£¬once mentioned of 37444-46-5

IMMUNOMODULATOR COMPOUNDS

Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 37444-46-5, name is Pyridazin-3-ylmethanol, introducing its new discovery. name: Pyridazin-3-ylmethanol

PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 37444-46-5, name is Pyridazin-3-ylmethanol, introducing its new discovery. Product Details of 37444-46-5

PURINE DERIVATIVES AND MEDICINE CONTAINING THE SAME AS THE ACTIVE INGREDIENT

Purine derivatives represented by the following formula and salts thereof: wherein R1represents a C1-C4alkyl group or difluoromethyl group; R2represents tetrahydrofuranyl group, a C1-C7alkyl group and the like; X represents hydrogen atom, a halogen atom or nitro group; and A represents a group represented by the following formula: wherein R3represents hydrogen atom, a halogen atom and the like; R4and R5represent hydrogen atom, a halogen atom, a C1-C4alkyl group, a C1-C4alkoxyl group and the like, which are useful as active ingredients of medicaments such as antiasthmatic agents.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N333 – PubChem

 

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1,2,3-TRIAZOLO<1,5>AZINES ET AUTRES HETEROCYCLES AZOTES DERIVES D’AZINE-CARBOXALDEHYDES

alpha-(N)-azine-carboxaldehydes are convenient precursors of 1,2,3-triazolo<1,5>azines.Through oxidative cyclisation of the corresponding hydrazones we have prepared the new 1,2,3-triazolo<1,5-b>pyridazine and 1,2,3-triazolo<1,5-a>pyrazine.Unlike the other azaindolizines these compounds are degraded by electrophiles. attempts to prepare imidazo<1,5-c>pyrimidine or derivatives have been carried out either from 4-aminomethylpyrimidine or from ethyl 2-(4-pyrimidinyl)propionate.

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Reactive mesogen and liquid crystal composition including the same

Provided are a reactive mesogen that may improve display quality of a liquid crystal display, and a liquid crystal composition including the same. The reactive mesogen is represented by the following Formula: where A1, A2, and A3 are each independently a substituted or unsubstituted divalent hydrocarbon ring, or a substituted or unsubstituted divalent heterocycle, L1 and L2 are each independently a direct linkage, ?O?, ?S?, ?CO?, ?COO?, ?OCOO?, ?O(CH2)k1?, ?S(CH2)k1?, ?O(CF2)k1?, ?S(CF2)k1?, ?(CH2)k1?, ?CF2CH2?, ?(CF2)k1?, ?CH?CH?, ?CF?CF?, ?C?C?, ?CH?CH?COO?, or ?(CH2)k1?COO?(CH2)k2?O?, Z1 and Z2 are each independently a direct linkage, ?O?, ?S?, ?CO?, ?COO?, ?OCOO?, ?O(CH2)m1?, ?S(CH2)m1?, ?O(CF2)m1?, ?S(CF2)m1?, ?(CH2)m1?, ?CF2CH2?, ?(CF2)m1?, ?CH?CH?, ?CF?CF?, ?C?C?, ?CH?CH?COO?, ?(CH2)m1?COO?, ?(CH2)m1?COO?(CH2)m2?O?, ?CH?(Sp?Pa)?, ?CH2CH?(Sp?Pa)?, or ?(CH?(Sp?Pa)?CH?(Sp?Pa))?, Pa is a polymerizable group, B is an unsubstituted heterocycle, a substituted or unsubstituted crown ether group, or wherein T1 and T2 are each independently ?OH, ?CH3, ?CF3, ?CHF2, ?CH2F, ?CH2Br, ?CHBr2, ?CHCl2, or ?CH2Cl.

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SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME

Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

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Electric Literature of 37444-46-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 37444-46-5, Pyridazin-3-ylmethanol, introducing its new discovery.

Orally active cephalosporins. Part 3: Synthesis, structure-activity relationships and oral absorption of novel C-3 heteroarylmethylthio cephalosporins

A series of 7beta-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3- (heteroarylmethylthio)cephalosporins was designed, synthesized and evaluated for antibacterial activity and oral absorption in rats. Antibacterial activity was markedly influenced by the structure of the heteroaromatic ring moiety. Oral absorption was influenced by the heteroaromatic ring moiety as well as by the arrangement of heteroatoms. Among these compounds, FK041 (2o), having a 4-pyrazolylmethylthio moiety, showed potent antibacterial activity against both Gram-positive and Gram-negative bacteria including Haemophilus influenzae. Further, it showed higher oral absorption than CFDN.

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Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction

Compounds of the formulae (IA) and (IB): wherein R1 is C1 to C3 alkyl optionally substituted with phenyl, Het or a N-linked heterocyclic group selected from piperidinyl and morpholinyl; wherein said phenyl group is optionally substituted by one or more substitutents selected from C1 to C4 alkoxy; halo; CN; CF3; OCF3 or C1 to C4 alkyl wherein said C1 to C4 alkyl group is optionally substituted by C1 to C4 haloalkyl or haloalkoxy either of which is substituted by one or more halo atoms; R2 is C1 to C6 alkyl and R13 is OR3 or NR5R6, or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity are potent and selective inhibitors of type 5 cyclic guanosine 3?,5?-monophosphate phosphodiesterase (cGMP PDE5) and have utility in the treatment of, inter alia, male erectile dysfunction (MED) and female sexual dysfunction (FSD).

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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37444-46-5,Pyridazin-3-ylmethanol,as a common compound, the synthetic route is as follows.

[00284] Thionyl chloride (3.05 ml, 42 mmol) was added to an ice-cooled flask containing the title compound of Preparation 26 (920 mg, 8 mmol) and the reaction mixture stirred for 45 minutes at room temperature, then evaporated under reduced pressure. The residue was azeotroped with toluene (40 ml) to furnish the crude title compound (1.4 g) as a brown solid, which was of sufficient purity for generating the free base required for use in subsequent alkylation reactions. delta (DMSOd6): 4.98 (2H, s), 7.80 (1H, m), 7.90 (1H, d), 8.19 (1H, s), 9.22 (1H, d).

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Reference£º
Patent; Pfizer Inc.; US6723719; (2004); B1;,
Pyridazine – Wikipedia
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