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372118-01-9, 372118-01-9 Methyl 4,6-dichloropyridazine-3-carboxylate 17848322, apyridazine compound, is more and more widely used in various fields.

372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Into a 3-dram vial were charged tert-butyl 2-(morpholin-3- yl)acetate (1.2 equiv.), methyl 4,6-dichloropyridazine-3-carboxylate (1.0 equiv.) and DMF (0.3 M). To the mixture at room temperature was added DIEA (3.0 equiv). The mixture was agitated in heating block at 70 C. After 5 h, the mixture was concentrated in vacuo and the residue purified by flash chromatography (0-100% EtOAc/heptane) to afford the desired product methyl 4-(3 -(2-(tert-butoxy)-2-oxoethyl)morpholino)-6-chl oropyridazine3-carboxylate in 77% isolated yield. LCMS (m/z) (M+H) = 372.1, Rt = 1.25 mm.

372118-01-9, 372118-01-9 Methyl 4,6-dichloropyridazine-3-carboxylate 17848322, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; AVERSA, Robert John; BURGER, Matthew T.; DILLON, Michael Patrick; DINEEN JR., Thomas A.; KARKI, Rajesh; RAMURTHY, Savithri; RAUNIYAR, Vivek; ROBINSON, Richard; SARVER, Patrick James; (374 pag.)WO2017/103824; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

Some tips on 372118-01-9

The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.

372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (20.7 g, 100 mmol),2,4-dimethoxybenzylamine (17.5 g, 105 mmol)And diisopropylethylamine (25.84 g, 200 mmol) were dissolved in acetonitrile (800 mL).After stirring at room temperature for 15 hours,The solvent was removed under reduced pressure, and the residue was dispersed in water (1 L).After stirring for 30 minutes, it was filtered. The filtered solid was washed with water (300 mL) and cold acetonitrile (300 mL) in this order.The target product 6-chloro-4-((2,4-dimethoxybenzyl) amino) pyridazine-3-carboxylic acid methyl ester 31a (26 g, white solid) was obtained,Yield: 76%., 372118-01-9

The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

Analyzing the synthesis route of 372118-01-9

As the paragraph descriping shows that 372118-01-9 is playing an increasingly important role.

372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 6-Chloro-4-(1-methyl-1H-pyrazol-3-ylamino)-pyridazine-3-carboxylic acid methyl ester 4,6-Dichloro-pyridazine-3-carboxylic acid methyl ester (165 mg, 0.8 mmol) and 1-methyl-1H-pyrazol-3-amine (81 mg, 0.837 mmol) were dissolved in of N-methylpyrrolidinone (3.2 mL). The reaction was heated at 110 C. for 2 h, then cooled and concentrated in vacuo. The residue was diluted with water and then extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (sodium sulfate), filtered and concentrated in vacuo. Purification by chromatography (silica, 10 to 70% ethyl acetate in hexanes) gave 6-chloro-4-(1-methyl-1H-pyrazol-3-ylamino)-pyridazine-3-carboxylic acid methyl ester (69 mg, 32%) as a light brown solid. 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 10.09 (br. s., 1H) 8.24 (s, 1H) 7.34 (d, J=2.3 Hz, 1H) 6.02 (d, J=2.3 Hz, 1H) 4.08 (s, 3H) 3.91 (s, 3H); LCMS (EI/CI) m/z: 268 [M+H]., 372118-01-9

As the paragraph descriping shows that 372118-01-9 is playing an increasingly important role.

Reference£º
Patent; Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael; US2013/178478; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

Simple exploration of 372118-01-9

The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.372118-01-9,Methyl 4,6-dichloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.,372118-01-9

Step 1: To a solution of methyl 4,6-dichloropyridazine-3-carboxylate (2.05 g, 9.9 mmol) in CH3CN (26 mL) was added a solution of methyl 2-sulfanylacetate (0.90 mL, 10.0 mmol) in CH3CN (8.5 mL) dropwise at 0 C. Upon completion of addition, Et3N (1.40 mL, 10.0 mmol) was added dropwise. The reaction stirred at 0 C for 15 min. After 15 min, an additional portion of Et3N (1.40 mL, 10.0 mmol) was added and the mixture was allowed to warm to room temperature and stirred overnight. The reaction was diluted with water and concentrated. The mixture was acidified with 4N HC1 to pH ~ 3 and the bright yellow solution turned colorless and a white precipitate was formed. The solid was collected by filtration and washed with water to afford methyl 3-chloro-7-hydroxy-thieno[3,2-c]pyridazine-6-carboxylate (2.26 g, 93.1% yield) as white solid. MS m/z 245.1 [M+H]+.

The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PTC THERAPEUTICS, INC.; SYDORENKO, Nadiya; ALAM, Md Rauful; ARNOLD, Michael A.; BABU, Suresh; BHATTACHARYYA, Anuradha; CHEN, Guangming; GERASYUTO, Aleksey I.; KARP, Gary Mitchell; KASSICK, Andrew J.; MAZZOTTI, Anthony R.; MOON, Young-Choon; NARASIMHAN, Jana; PATEL, Jigar; TURPOFF, Anthony; WOLL, Matthew G.; YAN, Wuming; ZHANG, Nanjing; (0 pag.)WO2020/5873; (2020); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

Simple exploration of 372118-01-9

The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.

Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (414 mg, 2.00 mmol)And 5- (methylthio) pyridin-2-amine (280 mg, 2 mmol) were dissolved in ethanol (3 mL), heated at 120 C in a microwave reactor, and stirred for 3 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 50/1 to 1/1),The target product 6-chloro-4-((5- (methylthio) pyridin-2-yl) amino) pyridazine-3-carboxylic acid methyl ester 14a (120 mg, yellow oil) was obtained,Yield: 19%.

The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.

Some tips on 372118-01-9

The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.

372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (581 mg, 2.81 mmol),4-morpholinoaniline 92c (500mg, 2.81mmol),Diisopropylethylamine (3.63 g, 28 mmol) and acetonitrile (10 mL) were mixed, heated to 90 C and stirred for 18 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 100/0 to 1/4),The target product 6-chloro-4-((4-morpholinophenyl) amino) pyridazine-3-carboxylic acid methyl ester 92d (768 mg, brown solid) was obtained in a yield of 78%.

The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.