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A series of 2-aminophenyl-5-phenyl-4-[3-oxo-1,4-benzoxazin6-yl]thiazoles 5a-n have been prepared and evaluated for their COX-2 inhibition activity.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N979 – PubChem

Electric Literature of 35857-89-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.35857-89-7, Name is 6-Chloropyridazine-3-carbonitrile, molecular formula is C5H2ClN3. In a Patent，once mentioned of 35857-89-7

The synthesis of benzoxazinyl- and benzothiazinylpyridazinone compounds is described. The novel compounds are cardiotonic agents and inhibitors of phosphodiesterase. In addition, the compounds are useful as smooth muscle relaxants and bronchodilators

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Pyridazine – Wikipedia,
Pyridazine | C4H4N843 – PubChem

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For adult women in the United States, breast cancer is the most prevalent form of cancer. Compounds that target dysregulated signal transduction can be efficacious anti-cancer therapies. A prominent signaling pathway frequently dysregulated in breast cancer cells is the Wingless-related integration site (Wnt) pathway. The purpose of the work was to optimize a ?hit? from a screening campaign. 76,000 compounds were tested in a Wnt transcription assay and revealed potent and reproducible ?hit,? compound 1. Medicinal chemistry optimization of 1 led to more potent and drug-like molecules, 19, 24 and 25 (i.e., Wnt pathway IC50 values = 11, 18 and 7 nM, respectively). The principal results showed compounds 19, 24 and 25 were potent anti-proliferative agents in breast cancer cell lines, MCF-7 (i.e., IC50 values = 10, 7 and 4 nM, respectively) and MDA-MB 231 (i.e., IC50 values = 13, 13 and 16 nM, respectively). Compound 19 synergized anti-proliferation with chemotherapeutic Doxorubicin in vitro. A major conclusion was that compound 19 enhanced anti-proliferation of Doxorubicin in vitro and in a xenograft animal model of breast cancer.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N958 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 35857-89-7, name is 6-Chloropyridazine-3-carbonitrile, introducing its new discovery. name: 6-Chloropyridazine-3-carbonitrile

Pyruvate dehydrogenase kinases (PDKs) are overexpressed in most cancer cells and are responsible for aberrant glucose metabolism. We previously described bis(4-morpholinyl thiocarbonyl)-disulfide (JX06, 16) as the first covalent inhibitor of PDK1. Here, on the basis of the scaffold of 16, we identify two novel types of disulfide-based PDK1 inhibitors. The most potent analogue, 3a, effectively inhibits PDK1 both at the molecular (kinact/Ki = 4.17 × 103 M-1 s-1) and the cellular level (down to 0.1 muM). In contrast to 16, 3a is a potent and subtype-selective inhibitor of PDK1 with >40-fold selectivity for PDK2-4. 3a also significantly alters glucose metabolic pathways in A549 cells by decreasing ECAR and increasing ROS. Moreover, in the xenograft models, 3a shows significant antitumor activity with no negative effect to the mice weight. Collectively, these data demonstrate that 3a may be an excellent lead compound for the treatment of cancer as a first-generation subtype-selective and covalent PDK1 inhibitor.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N945 – PubChem

Reference of 35857-89-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 35857-89-7, molcular formula is C5H2ClN3, introducing its new discovery.

Under aerobic copper catalysis, we herein report a direct alpha-C(sp3)-H nitroalkylation of N-unsubstituted (hetero)arene-fused cyclic amines with nitroalkanes. The transformation proceeds with good substrate and functional group compatibility, high step and atom efficiency, and operational simplicity.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 35857-89-7 is helpful to your research. Reference of 35857-89-7

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N942 – PubChem

Related Products of 35857-89-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 35857-89-7, molcular formula is C5H2ClN3, introducing its new discovery.

Herein, a new iodide-mediated three-component annulation reaction of secondary anilines, cyclohexanones, and elemental sulfur is demonstrated, which allows access to various phenothiazines with the merits of formation of multiple chemical bonds in one single operation, high step and atom efficiency, readily available feedstocks and catalyst system, and good substrate and functional group compatibility. The developed chemistry capable of constructing novel phenothiazines with structural diversity offers a significant basis for further applications.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N907 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 35857-89-7, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 35857-89-7, name is 6-Chloropyridazine-3-carbonitrile. In an article，Which mentioned a new discovery about 35857-89-7

The present invention is related to a compound of formula (I): wherein i, j, n, o, p, q, r, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b and R4 are as defined herein, or an addition salt with an acid thereof, or a hydrate or solvate thereof, its preparation, pharmaceutical composition, and uses for treating a disease in which the enzyme 11beta-HSD1 is involved.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N822 – PubChem

Application of 35857-89-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 35857-89-7, 6-Chloropyridazine-3-carbonitrile, introducing its new discovery.

Air-stable P,N-bidentate ligands L1-L7 with cyclic secondary amine moieties linked to the benzene rings of triphenylphosphine were designed and prepared. The chelating coordination mode of the P,N-bidentate ligands to the Pd(II) center was confirmed by determining the X-ray structures of the Pd(II) complexes C1 and C2 derived from ligands L1 and L2, respectively. The ligands were used for the selective synthesis of delta-lactone through the palladium (Pd)-catalyzed telomerization of 1,3-butadiene with carbon dioxide. The highest yield (60% with 79% selectivity) was observed using the Pd2(dba) 3/4-(2-(diphenylphosphino)phenyl)morpholine (L2) catalyst system.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N914 – PubChem

Reference of 35857-89-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.35857-89-7, Name is 6-Chloropyridazine-3-carbonitrile, molecular formula is C5H2ClN3. In a Article，once mentioned of 35857-89-7

An efficient and halogen-free catalytic methodology for the synthesis of beta-amino alcohols from aromatic amines and biomass-derived carbohydrates is demonstrated for the first time. The activation of C5/C6 sugars by a ruthenium catalyst selectively generates the C2 alkylating reagent glycolaldehyde. The transformation involves metal-catalyzed hydrogen borrowing for the reduction of the imine intermediate. A series of arylamines bearing various substituents were successfully transformed into the desired products in good to excellent yields.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N933 – PubChem

Application of 35857-89-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 35857-89-7, molcular formula is C5H2ClN3, introducing its new discovery.

Herein, by employing dehydrogenation as a substrate-activating strategy, a new iridium-catalyzed direct alpha-functionalization of (hetero)aryl-fused cyclic secondary amines with indoles has been demonstrated, which proceeds with merits that include high step- and atom-efficiency, readily available feedstocks, a simple catalyst system, good functional group tolerance, and operational simplicity.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N908 – PubChem