Category: 35857-89-7

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-chl oro-Af4-(3 -ethyl pi peri di n-4-yl )-Af4-m ethyl -Af2-(3 – methylimidazo[l,2-a]pyridin-7-yl)pyrimidine-2, 4-diamine (100 mg, 0.250 mmol) and 6- chloropyridazine-3-carbonitrile (53 mg, 0.380 mmol) in ethanol (20 mL) was added TEA (78 mg, 0.771 mmol). The mixture was stirred at rt overnight and concentrated in vacuo. The residue was purified by preparative TLC (MeOH/DCM (v/v) = 1/20) to afford the title compound as a yellow solid (86 mg, yield 68%).MS (ESI, pos. ion) m/z: 503.4 [M+H]+;1H NMR (400 MHz, DMSO-d6) d (ppm): 9.91 (s, 1H), 8.29-8.23 (m, 2H), 8.15 (s, 1H), 7.84 (d, J = 9.7 Hz, 1H), 7.41 (d, j= 9.8 Hz, 1H), 7.35 (s, 1H), 7.28 (s, 1H), 4.71 (d, j= 26.9 Hz, 2H), 4.44 (s, 1H), 3.26 (s, 2H), 2.97 (s, 3H), 2.42 (s, 3H), 1.98 (d, j = 11.6 Hz, 1H), 1.93 – 1.74 (m, 2H), 1.43 (s, 1H), 1.06 (s, 1H), 0.87 (t, j= 7.2 Hz, 3H).

The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a deoxygenated mixture of 6-chloropyridazine-3-carbonitrile (100 mg, 0.717 mmol) , (4- (methylsulfonyl) phenyl) boronic acid (215 mg, 1.08 mmol) , and sodium carbonate (190 mg, 1.79 mmol) in dioxane (3 mL) and water (0.600 mL) was added PdCl2(dppf) (58 mg, 0.072 mmol) , and the resulting mixture was heated at 80 for 3 h under a nitrogen atmosphere. The mixture was cooled and filtered. The filtrate was concentrated and the residue was purified by column chromatography on silica gel (0-10MeOH/DCM) to afford the title compound. MS: m/z 260.0 (M + 1) .

As the paragraph descriping shows that 35857-89-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; COOKE, Andrew J.; PITTS, Daniel; JOHNSON, Adam; BESHORE, Douglas C.; HURZY, Danielle; MITCHELL, Helen; FRALEY, Mark; MCCOMAS, Casey; SCHIRRIPA, Kathy; MERCER, Swati P.; NANDA, Kausik; MENG, Dongfang; WU, Jane; BABAOGLU, Kerim; LI, Chun Sing; MAO, Qinghua; QI, Zhiqi; (156 pag.)WO2016/54807; (2016); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a deoxygenated mixture of 6-chloropyridazine-3-carbonitrile (100 mg, 0.717 mmol) , (4- (methylsulfonyl) phenyl) boronic acid (215 mg, 1.08 mmol) , and sodium carbonate (190 mg, 1.79 mmol) in dioxane (3 mL) and water (0.600 mL) was added PdCl2(dppf) (58 mg, 0.072 mmol) , and the resulting mixture was heated at 80 for 3 h under a nitrogen atmosphere. The mixture was cooled and filtered. The filtrate was concentrated and the residue was purified by column chromatography on silica gel (0-10MeOH/DCM) to afford the title compound. MS: m/z 260.0 (M + 1) .

As the paragraph descriping shows that 35857-89-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; COOKE, Andrew J.; PITTS, Daniel; JOHNSON, Adam; BESHORE, Douglas C.; HURZY, Danielle; MITCHELL, Helen; FRALEY, Mark; MCCOMAS, Casey; SCHIRRIPA, Kathy; MERCER, Swati P.; NANDA, Kausik; MENG, Dongfang; WU, Jane; BABAOGLU, Kerim; LI, Chun Sing; MAO, Qinghua; QI, Zhiqi; (156 pag.)WO2016/54807; (2016); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Of methyl (piperidin-4-yl) -carbamic acid tert-butyl ester (605.8mg, 2.83mmol) and 6-chloro-pyridazin-3-carbonitrile (796.5mg, 5.71mmol)In ethanol (15mL) was added triethylamine (1.14g, 11.30mmol). The reaction was stirred overnight at room temperature, and then concentrated under reduced pressure.The resulting residue was purified by silica gel column chromatography (EtOAc / PE (v / v) = 1/1) to give the title compound as a yellow solid (252.0mg, yield28.1%).

The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Xi, Ning; Li, Minxiong; Li, Xiaobo; Dai, Weilong; Hu, Haiyang; Zhang, Tao; Chen, Wuhong; (105 pag.)CN105461694; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of N4-((3R,65)-6-aminohexahydrofuro[3,2-*]furan-3-yl)-5-chloro-N2-(l- methyl-lH-pyrazol-4-yl)pyrimidine-2,4-diamine (32 mg, 0.091 mmol) in butan-l-ol (20 mL) were added 6-chloropyridazine-3-carbonitrile (25 mg, 0.179 mmol) and triethylamine (42 mg, 0.415 mg). The reaction was stirred at 120 C for 20 hours and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v) = 1/30) to give the title compound as a yellow solid (17 mg, 0.037mmol, yield 41%). LC-MS (ESI, pos. ion) m/z: 455.4 [M+H]+;1H NMR (400 MHz, CDCh) delta (ppm): 7.81 (s, 1H), 7.55 (s, 1H), 7.48 (s, 1H), 7.40 (d, J = 9.1 Hz, 1H), 6.78 (d, J = 9.3 Hz, 1H), 4.71 (s, 1H), 4.64-4.57 (m, 3H), 4.24-4.14 (m, 2H), 4.00-3.96 (m, 1H), 3.81 (s, 3H), 3.69-3.66 (m, 3H).

The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem