Category: 28682-73-7

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When 3-chloro-4,5-diaminopyridazine (2) was treated with sodium methylmercaptide in refluxing N,N-dimethylformamide, two heterocycles were formed and isolated, neither of which was the expected 3-methylthio-4,5-diaminopyridazine (3).A thorough spectral analysis of these heterocycles showed them to be 4-methylthioimidazo<4,5-d>pyridazine (5) and imidazo<4,5-d>pyridazine-4-thione (6).N,N-Dimethylformamide was found to provide the one carbon unit required for the formation of 5.The origin of 6 was shown to be a result of S-demethylation of 5.S-Demethylation of 3 could also be effected with sodium methylmercaptide in methyl sulfoxide without the occurrence of annulation.In methyl sulfoxide the process of demethylation was accelerated and occurred at lower temperature.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 28682-73-7. In my other articles, you can also check out more blogs about 28682-73-7

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N527 – PubChem

 

Application of 28682-73-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.28682-73-7, Name is 4,5-Diaminopyridazin-3(2H)-one, molecular formula is C4H6N4O. In a article，once mentioned of 28682-73-7

The syntheses of certain 4-(alkylthio)-, 4-<(arylalkyl)thio>-, and 4-(arylthio)imidazo<4,5-d>pyridazines from imidazo<4,5-d>pyridazine-4-thione (1, 4-SIP) are described.When 1 equiv of alkylating agent is used, alkylation occurs, as expected, on sulfur; however, when an excess of alkylating agent is employed, dialkylated products are formed.A rigorous spectroscopic study and an unequivocal synthesis of 6-methyl-4-(methylthio)imidazo<4,5-d>pyridazine (3a) has shown the second site of alkylation to be N6 of the imidazo<4,5-d>pyridazine ring.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 28682-73-7

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N526 – PubChem

 

Synthetic Route of 28682-73-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 28682-73-7, 4,5-Diaminopyridazin-3(2H)-one, introducing its new discovery.

Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same

The invention relates to novel 2-phenyl-imidazoles of the formula STR1 and the tautomers and acid addition salts thereof, particularly the pharmacologically acceptable acid addition salts, which exhibit valuable pharmacological properties, particularly an effect on the contractility of the heart muscle. The compounds of Formula I may be prepared by methods conventionally used for similar compounds.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 28682-73-7. In my other articles, you can also check out more blogs about 28682-73-7

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N525 – PubChem

 

Reference of 28682-73-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 28682-73-7, 4,5-Diaminopyridazin-3(2H)-one, introducing its new discovery.

S-Demethylation of Nitrogen Heterocycles

When 3-chloro-4,5-diaminopyridazine (2) was treated with sodium methylmercaptide in refluxing N,N-dimethylformamide, two heterocycles were formed and isolated, neither of which was the expected 3-methylthio-4,5-diaminopyridazine (3).A thorough spectral analysis of these heterocycles showed them to be 4-methylthioimidazo<4,5-d>pyridazine (5) and imidazo<4,5-d>pyridazine-4-thione (6).N,N-Dimethylformamide was found to provide the one carbon unit required for the formation of 5.The origin of 6 was shown to be a result of S-demethylation of 5.S-Demethylation of 3 could also be effected with sodium methylmercaptide in methyl sulfoxide without the occurrence of annulation.In methyl sulfoxide the process of demethylation was accelerated and occurred at lower temperature.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 28682-73-7. In my other articles, you can also check out more blogs about 28682-73-7

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N527 – PubChem