Category: 28682-70-4

28682-70-4, Name is Pyridazine-4,5-diamine, belongs to pyridazine compound, is a common compound. Electric Literature of 28682-70-4In an article, once mentioned the new application about 28682-70-4.

The present invention provides compounds of Formula (I) that are GPR6 modulators and are therefore useful for the treatment of diseases treatable by modulation of GPR6, in particular treating Parkinson disease, levodopa induced dyskinesias, Huntington’s disease, other dyskinesias, akinesias, and motor disorders involving dysfunction of the striatum, schizophrenia and drug ad­diction. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds

Keep reading other articles of 28682-70-4! Don’t worry, you don’t need a PhD in chemistry to understand the explanations! Electric Literature of 28682-70-4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N356 – PubChem

 

Related Products of 28682-70-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 28682-70-4, Pyridazine-4,5-diamine, introducing its new discovery.

4-Nitro-3-R1-6-R2-pyridazines (1) (a, R1 = R2 =2-pyridyl; b, R1 = H, R2 = phenyl; c, R1 = H, R2 = p-methoxyphenyl; d, R1 = R2 = H) are aminated by liquid ammonia/potassium permanganate to the corresponding 5-amino-4-nitropyridazines 3a-d.The 4-cyano-3-R1-6-R2-pyridazines 4a,b are only aminated in the presence of potassium amide in liquid ammonia/potassium permanganate to give the 5-amino-4-cyanopyridazines 6a,b.The 5-amino-4-nitropyridazines 3a,b,d are converted to the 4,5-diaminopyridazines 7a,b,d by reduction over a Pd/C catalyst.Reaction of7b with glyoxal leads to 5-phenylpyrazino<2,3-d>pyridazine (8b).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 28682-70-4. In my other articles, you can also check out more blogs about 28682-70-4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N359 – PubChem

 

Related Products of 28682-70-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.28682-70-4, Name is Pyridazine-4,5-diamine, molecular formula is C4H6N4. In a Patent，once mentioned of 28682-70-4

The present invention relates to an organic light emitting compound which is employed in an organic light emitting device. The compound is represented by chemical formula 1. An organic light emitting device has excellent light emitting properties in driving voltage, luminance, and long lifespan, when the compound is employed as a phosphorescent host compound in a light emitting layer.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 28682-70-4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N357 – PubChem

 

Synthetic Route of 28682-70-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.28682-70-4, Name is Pyridazine-4,5-diamine, molecular formula is C4H6N4. In a article，once mentioned of 28682-70-4

The present invention provides compounds of Formula (I) that are GPR6 modulators and are therefore useful for the treatment of diseases treatable by modulation of GPR6, in particular treating Parkinson disease, levodopa induced dyskinesias, Huntington’s disease, other dyskinesias, akinesias, and motor disorders involving dysfunction of the striatum, schizophrenia and drug ad­diction. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 28682-70-4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N356 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: Pyridazine-4,5-diamine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 28682-70-4, Name is Pyridazine-4,5-diamine, molecular formula is C4H6N4

QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula (I) including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: Pyridazine-4,5-diamine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 28682-70-4, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N358 – PubChem

 

Electric Literature of 28682-70-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 28682-70-4, Name is Pyridazine-4,5-diamine,introducing its new discovery.

2-phenyl-imidazo-pyrazines, useful as cardiotonics

Compounds of the formula STR1 wherein A, B, C and D are each independently –N= or –CH=, provided, however, that at least two of them must be –N=, and when A and C are both –N=, at least one or both of B and D must be –N=; and R1, R2 and R3 are substituents of diverse types; tautomers thereof; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds are useful as cardiotonics.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 28682-70-4, and how the biochemistry of the body works.Electric Literature of 28682-70-4

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N355 – PubChem

 

28682-70-4, Pyridazine-4,5-diamine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0463] Example 17 [0464] Synthesis of N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperazin-l-yl)pyrazino[2,3- d]pyridazin-2-amine, 2,2,2-trifluoroacetic acid salt [0465] Step 1 : pyrazino[2,3-d]pyridazine-2,3(lH,4H)-dione [0466] A solution of pyridazine-4,5-diamine (200 mg, 1.816 mmol), oxalic acid (196 mg, 2.179 mmol) and aq hydrogen chloride (2.7 mL, 10.90 mmol, 4.0 N) was heated at reflux for 20 h. The reaction mixture was cooled to RT and the resulting precipitate was filtered, washed with water and dried under vacuum to afford the title compound as a white solid.

28682-70-4, 28682-70-4 Pyridazine-4,5-diamine 14219879, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ENVOY THERAPEUTICS, INC.; HITCHCOCK, Stephen; MONENSCHEIN, Holger; REICHARD, Holly; SUN, Huikai; KIKUCHI, Shota; MACKLIN, Todd; HOPKINS, Maria; WO2014/28479; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28682-70-4,Pyridazine-4,5-diamine,as a common compound, the synthetic route is as follows.

The mixture of intermediate 13 (4.6 g, 41.8 mmol, 1 eq.) and ethyl 2-oxoacetate (10.2 g, 50.1 mmol, 1.2 eq. 50% in toluene) in EtOH (240 ml) was stirred overnight at 80C. The solvent was removed under vacuum. The residue was reflux for 3 h in CH3CN, and then filtered to give pure intermediate 14 (3.07 g, yield 49.7%).

28682-70-4, As the paragraph descriping shows that 28682-70-4 is playing an increasingly important role.

Reference£º
Patent; JANSSEN R&D IRELAND; TAHRI, Abdellah; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; DEMIN, Samuel Dominique; WO2014/114776; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem