Category: 2605-67-6

2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, molecular formula is C21H19O2P, belongs to pyridazines compound, is a common compound. In a patnet, author is Zhu, Guanxing, once mentioned the new application about 2605-67-6, Computed Properties of C21H19O2P.

Access to a Phthalazine Derivative Through an Angular cis-Quinacridone

Intramolecular electrophilic cyclization of a bisanthranilate afforded an angular cis-quinacridone compound, which condensed with hydrazine to give a phthalazine derivative. A [2+2+2] cyclization reaction occurred at the C-N double bond position of phthalazine when reacted with dimethyl acetylenedicarboxylate. The structures of these novel compounds were confirmed by crystallographic analysis. The phthalazine derivative decomposes back to quinacridone at ambient condition in the dark and as a solid with a half lifetime of about 22 months.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, SMILES is C3=C([P](C1=CC=CC=C1)(C2=CC=CC=C2)=CC(OC)=O)C=CC=C3, in an article , author is Adiraju, Venkata A. K., once mentioned of 2605-67-6, Computed Properties of C21H19O2P.

Isomer Dependence on the Reactivity of Diazenes with Pentaphenylborole

Reactions of the anti-aromatic pentaphenylborole with diazenes indicate that both the substitution and the isomer influence the reaction outcome. With respect to trans isomers, azobenzene underwent coordination and C-H addition across the diene of the borole, and 2′, 6′-dimethylazobenzene furnished a fused tricyclic system. Under photolytic conditions, both of the aforementioned diazenes generate the first 1,3,2-diazaborepin heterocycles, rationalized through reactivity with the cis isomers. This notion is corroborated by the reaction of pentaphenylborolewith benzo[c]-cinnoline, the tethered variant of azobenzene, that only exists as the cis conformer as the corresponding 1,3,2-diazaborepin was produced regardless if the reaction is conducted in the dark or light. The more aromatic pyridazine proved to be less reactive, forming a resilient adduct.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, molecular formula is C21H19O2P. In an article, author is Althagafi, Ismail,once mentioned of 2605-67-6, Formula: C21H19O2P.

Synthesis, Surface, and Antimicrobial Activity of Hydrophobically Thiadiazole, Pyridazine, and Pyrimidine Systems Based on Surface Active Agents

A series of hydrophobically thiadiazole, pyridazine, and pyrimidine were synthesized with surface and biological activities from cheap, available, and safe raw materials such as fatty acids. Thus, diazotizations of thiadiazole derivative 2 and malononitrile resulted a hydrazone derivative 3, which was used to construct various biologically active compounds with low toxicity, good solubility and biodegradation, surface properties with biological activity. The results revealed that these substances have the ability to reduce the surface tension, reduce the wetting time, varying degrees of foam and emulsifying stability, which makes use in the different industries. As well as their biodegradability, which confirms that these compounds are environmentally friendly to humans and the environment. Furthermore, the effect of these compounds against certain microorganisms has been studied and shown to be highly effective against the activity of these organisms.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, molecular formula is C21H19O2P, belongs to pyridazines compound, is a common compound. In a patnet, author is Hameed, R. S. Abdel, once mentioned the new application about 2605-67-6, Safety of Methyl 2-(triphenylphosphoranylidene)acetate.

Study of sulfanyl pyridazine derivatives as efficient corrosion inhibitors for carbon steel in 1.0 M HCl using analytical techniques

Five new sulfur containing heterocyclic derivatives of sulfanyl pyridazine type compounds (1-5) were synthesized, characterized by FT-IR and H-1 NMR, and evaluated as corrosion inhibitors for carbon steel in 1.0 M HCl at various concentration and temperatures. Five different analytical techniques were used in this study, namely, gravimetrical, gasometrical, atomic absorption spectroscopy, AAS, thermometric, and acidimetric techniques. The corrosion inhibition efficiency increases with increasing inhibitor concentration but decreases with temperature. The inhibition of corrosion is due to adsorption on the metal surface and formation of a barrier film that separates the metal from the corrosive medium. The inhibition is due to physicochemical adsorption of a heterocyclic compound on steel surface, and the adsorption obeys the Langmuir isotherm. Thermodynamic parameters for both activation and adsorption were computed and discussed. The reduction in reaction number (RR%) and Atm increased with increasing inhibitor concentrations. The pH increased and the hydrogen ion concentration in the medium decreased upon addition of inhibitors as an inhibitor molecule acts as a ligand for protons in acidic media. The ferrous ion Fe+2 concentrations determined by AAS decreased in the solution with increasing inhibitor concentration. The data obtained from different analytical techniques are in good agreement within (+/- 2%).

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 2605-67-6. The above is the message from the blog manager. Safety of Methyl 2-(triphenylphosphoranylidene)acetate.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Synthetic Route of 2605-67-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, SMILES is C3=C([P](C1=CC=CC=C1)(C2=CC=CC=C2)=CC(OC)=O)C=CC=C3, belongs to pyridazines compound. In a article, author is Ahmed, Eman M., introduce new discover of the category.

New pyridazine derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents; design, synthesis and biological evaluation

New pyridazinone and pyridazinthione derivatives were designed, synthesized and identified through performing H-1 NMR, C-13 NMR, IR and MS spectroscopic techniques. All the newly synthesized derivatives were evaluated for cyclooxygenase inhibitory activity and COX-2 selectivity using celecoxib and indomethacin, as reference drugs. All compounds showed highly potent COX-2 inhibitory activity with IC50 values in nano-molar range. Moreover, they demonstrated higher selectivity towards COX-2 inhibition compared to indomethacin. Compounds 3d, 3g and 6a exhibited significantly increased potency towards COX-2 enzyme compared to celecoxib with IC50 values of 67.23, 43.84 and 53.01 nM, respectively. They were 1.1-1.7 folds more potent than celecoxib (IC50 = 73.53 nM) and extremely much more potent than indomethacin (IC50 = 739.2 nM). Of particular interest, Compound 3g showed SI of 11.51 which was as high as that of celecoxib (SI 11.78). This compound was further challenged by in vivo anti-inflammatory activity assay and gastric ulcerogenic effect. It showed comparable anti-inflammatory activity to indomethacin as positive control. Moreover, the anti-inflammatory activity of compound 3g was found to be equipotent to celecoxib. Furthermore, the selective COX-2 inhibitor 3g exhibited a superior gastrointestinal safety profile compared to the reference drugs celecoxib and indomethacin with less number of ulcers and milder ulcer score. The molecular docking study of this compound with COX-2 protein revealed more favorable binding mode compared to celecoxib, explaining its remarkable COX-2 inhibitory potency.

Synthetic Route of 2605-67-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 2605-67-6 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, SMILES is C3=C([P](C1=CC=CC=C1)(C2=CC=CC=C2)=CC(OC)=O)C=CC=C3, belongs to pyridazines compound. In a document, author is Saraswat, Mayank, introduce the new discover, SDS of cas: 2605-67-6.

Through bond and through space interactions in dehydro-diazine radicals: a case study of 3c-5e interactions

Owing to the 3c-5e (3-centred-5-electrons) interactions between two nitrogen lone pairs and a radical electron, the dehydrodiazine radical isomers are very interesting from the fundamental point of view. Among them, pyrimidine has three (1a-1c), pyridazine has two (2a and 2b) and pyrazine has only one (3a) radical isomer. Based on quantum chemical calculations at the (U) B3LYP, (U) M06-2X, (U) BLYP, CBS-QB3 and (U) CCSD(T) levels with cc-pVTZ as the basis set, we found the 4-dehydropyrimidine (1b) radical to be the most stable isomer among the three pyrimidine radicals, followed by the 2-dehydropyrimidine (1a) and 5-dehydropyrimidine (1c) radical isomers. In the case of pyridazine, 3-dehydro radical isomer (2a) is more stable than 4-dehydropyridazine (2b). Bond dissociation energy (BDE) calculations and estimation of radical stabilization energies (RSE) using isodesmic reactions revealed the stability order among the six isomeric diazine radicals as 1c < 2b < 2a < 1a < 3a < 1b. Spin densities at each radical centre and non-zero values at nitrogen centres provided information about the extent of delocalization of radical electrons, which was consistent with the relative stability order of all the isomers. The multiconfigurational CASSCF and natural bond orbital (NBO) calculations suggested the presence of direct through space interactions (between lone pairs and a radical, TS) that play a dominant role over the through bond (through intervening bonds, TB) interactions in deciding the stability order. To confirm these results, we have also estimated the proton affinities (PAs) for each nitrogen atom and compared them with their respective parent diazines, where lowering of the PA values convincingly envisaged the extent and strength of interactions between the nitrogen and radical centre. Atoms-in-molecules (AIM) analysis and estimation of hyperfine coupling constants have also been performed to verify these results. All these results showed that the through space interaction between the lone pair and the radical electron is very important for the electronic structural and stability aspects in dehydrodiazine radicals. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2605-67-6 is helpful to your research. SDS of cas: 2605-67-6.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, SMILES is C3=C([P](C1=CC=CC=C1)(C2=CC=CC=C2)=CC(OC)=O)C=CC=C3, belongs to pyridazines compound. In a document, author is Moslin, Ryan, introduce the new discover, Name: Methyl 2-(triphenylphosphoranylidene)acetate.

Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)

As a member of the Janus OAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide 4, identified by a SPA-based high-throughput screen targeting the TYK2 pseudokinase domain, potently inhibits IL-23 and IFN alpha signaling in cellular assays. The described work details the optimization of this poorly selective hit (4) to potent and selective molecules such as 47 and 48. The discoveries described herein were critical to the eventual identification of the clinical TYK2 JH2 inhibitor (see following report in this issue). Compound 48 provided robust inhibition in a mouse IL-12-induced IFN gamma pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model. These results demonstrate the ability of TYK2 JH2 domain binders to provide a highly selective alternative to conventional TYK2 orthosteric inhibitors.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2605-67-6 is helpful to your research. Name: Methyl 2-(triphenylphosphoranylidene)acetate.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Synthetic Route of 2605-67-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, SMILES is C3=C([P](C1=CC=CC=C1)(C2=CC=CC=C2)=CC(OC)=O)C=CC=C3, belongs to pyridazines compound. In a article, author is Zhong, Ziping, introduce new discover of the category.

Poly(EDOT-pyridine-EDOT) and poly(EDOT-pyridazine-EDOT) hollow nanosphere materials for the electrochemical detection of Pb2+ and Cu2+

In this paper, an electrochemical sensor was developed for detecting heavy metal ions by using contains O, S and N atoms polymer hollow nanosphere materials for the electrochemical simultaneous detection of Pb2+ and Cu2+. poly(2,5-bis-(2,3-dihydrothieno[3,4-b][1,4]dioxyin-5-yl)pyridine) hollow nanosphere (poly(BPE)HNs) and poly(3,6-bis(3,4-ethylenedioxythienylpyridazine) hollow nanosphere (poly(EPE)HNs) were prepared by via chemical oxidative polymerization method. And the resulting products were characterized by FT-IR, UV-vis, TGA, XRD, TEM and SEM. The results indicated that two kinds of polymers were prepared successfully. Furthermore, the electrochemical sensors were applied for the electrochemical determination of Pb2+ and Cu2+ using DPV method. And the results indicated that poly(BPE)HNs modified glassy carbon electrode (poly(BPE) HNs/GCE) exhibited linear detection range from 0.012-4 mu M and 0.016-4 mu M for the Pb2+ and Cu2+, with the sensitivity of 19.51 mu A/mu M and 4.87 mu A/mu M. The detection limits (S/N = 3) of 0.005 mu M and 0.012 mu M, respectively. The real sample analysis suggested that the poly(BPE)HNs modified electrode can be applied for the detection of the Pb2+ and Cu2+ ions in tap water samples.

Synthetic Route of 2605-67-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 2605-67-6 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, molecular formula is C21H19O2P. In an article, author is Ning, Xiaowen,once mentioned of 2605-67-6, Quality Control of Methyl 2-(triphenylphosphoranylidene)acetate.

Green and yellow pyridazine-based phosphorescent Iridium(III) complexes for high-efficiency and low-cost organic light-emitting diodes

Despite efficient electroluminescence performance, the high fabrication cost due to the utilization of noble metals impedes the commercialization of phosphorescent organic light-emitting diodes (PHOLEDs) based on iridium(III) complexes. In this paper, we designed and synthesized a series of green and yellow phosphorescent iridium(III) complexes with 3-(2,4-difluorophenyl)-6-methylpyridazine as the cyclometalating ligand to fabricate high-performance and low-cost PHOLEDs. By the introduction of a pyridazine moiety to enhance the coordination bond between iridium(III) ion and cyclometalating ligands, these iridium(III) complexes were obtained in high yields and exhibit good thermal stabilities and volatilities, which are beneficial to reduce the device manufacturing cost. Besides, high photoluminescence quantum yields (PLQYs) and short phosphorescent lifetimes of these pyridazine-based iridium(III) complexes endow their PHOLEDs with excellent device performance, which can be promising for practical applications. Particularly, the green emitter (fpdz)(2)Irpic exhibited a high PLQY of 0.89 in solid doped thin-film; PHOLED based on (fpdz)(2)Irpic achieved an outstanding maximum external quantum efficiency (EQE(max)) of 28.7% with ultralow efficiency roll-off of 2% at the high luminance of 1000 cd m(-2), which was superior to the commercial green phosphor bis(phenylpyridineyl)iridium(acetylacetonate) [(ppy)(2)Ir(acac), EQE(max) = 24.2%].

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, molecular formula is C21H19O2P. In an article, author is Zhang, Yiwen,once mentioned of 2605-67-6, Application In Synthesis of Methyl 2-(triphenylphosphoranylidene)acetate.

Facile syntheses of ionic polymers for efficient catalytic conversion of CO2 to cyclic carbonates

The development of sustainable heterogeneous catalysts in converting carbon dioxide (CO2) into value-added chemicals is a promising way to alleviate the environmental pressure caused by global warming. Here, two novel ionic polymers (IPs, namely IP-1 and IP-2) with high yield and excellent physiochemical stability have been synthesized facilely from the direct reaction of 1,3,5-tris(bromomethyl)benzene with 1,4-diazabicyclo [2.2.2]octane and 3,6-di(1H-imidazol-1-yl)pyridazine, respectively. Their catalytic abilities to convert CO2 into cyclic carbonates have been explored, and both IP-1 and IP-2 show excellent catalytic activity under solvent free, cocatalyst-free, and mild reaction conditions, and can be recycled and reused six times without decreasing their catalytic abilities. These materials are easily synthesized, and there are no metals and other additives during the catalytic process, which provides a possibility for the industrial immobilization of CO2 to carbonate over heterogeneous catalysts.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem