Reference of 5-(Trifluoromethyl)pyridazin-3(2H)-oneOn March 6, 2020, Trofymchuk, Serhii; Bugera, Maksym Ya.; Klipkov, Anton A.; Razhyk, Bohdan; Semenov, Sergey; Tarasenko, Karen; Starova, Viktoriia S.; Zaporozhets, Olga A.; Tananaiko, Oksana Yu.; Alekseenko, Anatoliy N.; Pustovit, Yurii; Kiriakov, Oleksandr; Gerus, Igor I.; Tolmachev, Andrei A.; Mykhailiuk, Pavel K. published an article in Journal of Organic Chemistry. The article was 《Deoxofluorination of (Hetero)aromatic Acids》. The article mentions the following:
Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines – valuable building blocks for medicinal chem. and agrochem. Of note, sulfur tetrafluoride (SF4) and hydrogen fluoride (HF) are toxic, therefore, safety and addnl. tech. training must be taken before working with them. The experimental part of the paper was very detailed, including the reaction process of 5-(Trifluoromethyl)pyridazin-3(2H)-one(cas: 244268-34-6Reference of 5-(Trifluoromethyl)pyridazin-3(2H)-one)
5-(Trifluoromethyl)pyridazin-3(2H)-one(cas: 244268-34-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Reference of 5-(Trifluoromethyl)pyridazin-3(2H)-one
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem