Category: 2166-31-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2166-31-6,6-Phenylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: Appropriate 3(2H)-pyridazinone derivative (0.01 mol), ethyl bromoacetate (0.015 mol) and anhydrous potassium carbonate (0.02 mol) in 20 mL of anhydrous DMF were stirred at room temperature for 2 h, respectively. At the end of this period, the reaction mixture was poured into ice water and the resulting precipitate was filtered to give compounds 4 (mp 97 C; lit [20]: 92 C), 5 (mp 100-102 C; lit [21]:101C), 6 (mp 159 C; lit [22]:155 C), respectively., 2166-31-6

As the paragraph descriping shows that 2166-31-6 is playing an increasingly important role.

Reference£º
Article; Sukuroglu, Murat; Yamali, Cem; Tiryaki, Didem; Onurdag, Fatma Kaynak; Akkol, Esra; Dogruer, Deniz Songuel; Letters in drug design and discovery; vol. 10; 6; (2013); p. 507 – 514;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2166-31-6,6-Phenylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of pyridazinone derivative [32-34] (0.5 mmol) in DMF (10 mL) was added 1-(chloromethyl) 3-nitrobenzene (0.52 mmol) and Cs2CO3 (0.55 mmol), the resulting reaction mixture was stirred at 40-50 C until no starting materials was detected by TLC (about 3 h). The solvent was removed under reduced pressure and the residue was dissolved in EtOAc (30 mL), washed with brine (3 10 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo. The crude product was dissolved in 95% ethanol (50 mL) containing 10 mmol acetic acid. Iron powder (2 mmol) was added and the resulting mixture was stirred for 5 h. After cooled to room temperature, the reaction mixture was filtered through celite and the filter cake was washed with 95% ethanol (3 x 15 mL). The combined ethanol layers were evaporated in vacuo and the residue was re-dissolved in ethyl acetate (30 mL). The organic layer was washed with brine (3 x 10 mL) and 2 M NaOH (10 mL) sequentially. The organic layer was dried over anhydrous Na2SO4, evaporated in vacuo to afford the crude 2-aminobenzyl-6-substituted-pyridazin-3(2H)-ones, which were used without further purification. To a stirred solution of 2-aminobenzyl-6-substituted-pyridazin-3(2H)-one and triphosgene (1 mmol) in dry dichloromethane (5 mL) was added triethylamine (2 mmol) under nitrogen atmosphere. A solution of the corresponding piperidine (1 mmol) in dichloromethane (5 mL) was added 5-10 min later and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with dichloromethane (15 mL) and washed with water (3 x 20 mL). The organic phases were separated, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography to afford the products., 2166-31-6

As the paragraph descriping shows that 2166-31-6 is playing an increasingly important role.

Reference£º
Article; Xing, Weiqiang; Fu, Yan; Shi, Zhangxing; Lu, Dong; Zhang, Haiyan; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 95 – 103;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

2166-31-6, 6-Phenylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

135 ml (135 mmole) of a solution of phenylmagnesium bromide (IM) in THF was added to a hot suspension of 6-phenylpyridazinone compound 7.8g (45 mmole) in dry toluene (50 ml). The mixture was-refluxed for 8h, left overnight at ambient temperature, then decomposed with a saturated solution of ammonium chloride. The organic layer was separated, and the aqueous layer was extracted with 100ml of ethyl acetate. The solvent was removed and the residue was crystallized from ethanol. The crystals were collected by filtering and dried over a medium frit sintered glass funnel in vacuo to give 5.6 g of white crystals. Yield was 50%, confirmed by ESI-MS. ESI-MS: m/z 250.1 (M+H+)., 2166-31-6

The synthetic route of 2166-31-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NORTHWESTERN UNIVERSITY; WO2007/127475; (2007); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2166-31-6,6-Phenylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

135 ml (135 mmole) of a solution of phenylmagnesium bromide (IM) in THF was added to a hot suspension of 6-phenylpyridazinone compound 7.8g (45 mmole) in dry toluene (50 ml). The mixture was refluxed for 8h, left overnight at ambient temperature, then decomposed with a saturated solution of ammonium chloride. The organic layer was separated, and the aqueous layer was extracted with 100ml of ethyl acetate. The solvent was removed and the residue was crystallized from ethanol. The crystals were collected by filtering and dried over a medium frit sintered glass funnel in vacuo to give 5.6 g of white crystals. Yield was 50%, confirmed by ESI-MS. ESI-MS: m/z 250.1 (M+H+).

2166-31-6, As the paragraph descriping shows that 2166-31-6 is playing an increasingly important role.

Reference£º
Patent; NORTHWESTERN UNIVERSITY; WO2007/127474; (2007); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

2166-31-6, 6-Phenylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Addition of 68.9 g of 6-phenyl-3-pyridazinone g (0.4 mol) in a 500 ml four-neck flask, prepared in Example 1Modified ZSM-5 molecular sieve 7 g, 413.4 g of phosphorus oxychloride and 166.5 g of phosphorus pentachloride (0.8 mol), and then heated to 90C, and kept warmAfter half an hour of reaction, the temperature was raised to 110C and the reaction was refluxed for 4 hours. The reaction was completed. HPLC was used to determine the area normalized to give 3-phenyl-4-one.The ratio of chloropyridazine, 3-phenyl-4-6-dichloropyridazine, 3-phenyl-4-5-dichloropyridazine was 0.5:98.4:1.1;The reaction solution was distilled under reduced pressure to remove phosphorus oxychloride, and the temperature under vacuum distillation was 120C. The degree of vacuum was -0.098 MPa;After being bundled, it is cooled to room temperature, then 137.8g of toluene is added, stirred and heated to recrystallize, the Buchner funnel is filtered, and the wet product is blownThe box was dried at 80C for 8 hours to obtain 86.5 g of a white solid-like 3-phenyl-4-6-dichloropyridazine product (HPLC: 99.7%; Yield:95.3%).

2166-31-6, As the paragraph descriping shows that 2166-31-6 is playing an increasingly important role.

Reference£º
Patent; Changzhou Woteng Chemical Technology Co., Ltd.; Wan Zhibing; Wang Zhichao; Sun Kezhou; Liu Rong; (5 pag.)CN106831600; (2017); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2166-31-6,6-Phenylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

Example 123; l-(3-Morpholinopropyl)-3-(3-((6-oxo-3-phenyIpyridazin-l(6H)- yl)methyl)phenyl)urea (1) A mixture of 6-phenylpyridazin-3(2H)-one (4.1 g, 24 mmol), K2CO3 (3.3 g, 24 mmol), and l-(bromomethyl)-3 -nitrobenzene (5.1 g, 24 mmol) in DMF (25 mL) was stirred at rt for 1 day. The mixture was diluted with H2O (50 mL) and stirred for 30 min. The suspension was filtered, washed with H2O and dried in air to give a white solid (6.8 g). LCMS (ESI pos. ion): calc’d for Ci7Hi3N3O3:307.1; found 308.1 (M+l). 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 5.49 (s, 2 H) 7.05 (d, J-9.65 Hz, 1 H) 7.42 – 7.57 (m, 4 H) 7.71 (d, J=9.79 Hz, 1 H) 7.75 – 7.80 (m, 2 H) 7.83 (d, J=7.60 Hz, 1 H) 8.17 (dd, J=8.18, 2.05 Hz, 1 H) 8.35 (t, J=I .75 Hz, 1 H)., 2166-31-6

The synthetic route of 2166-31-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2008/103277; (2008); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem