Category: 20733-10-2

La Manna, Gianfranco et al. published their research in Gazzetta Chimica Italiana in 1972 | CAS: 20733-10-2

4-Hydroxypyridazine (cas: 20733-10-2) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C4H4N2O

Electronic structure of groups of isomeric heteroaromatic systems. V. Monohydroxydiazines and diazinones was written by La Manna, Gianfranco;Cignitti, Maurizio. And the article was included in Gazzetta Chimica Italiana in 1972.COA of Formula: C4H4N2O This article mentions the following:

π-Electron energies and π-dipole moments were calculated for 3-pyridazinol (I), 3(2H)-pyridazinone (II), 2-pyrimidinol (III), 2(1H)-pyrimidinone (IV), and 9 other pyridazine and pyrimidine keto-enol tautomers. The lactam structures were the most stable. In the experiment, the researchers used many compounds, for example, 4-Hydroxypyridazine (cas: 20733-10-2COA of Formula: C4H4N2O).

4-Hydroxypyridazine (cas: 20733-10-2) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C4H4N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Barlin, Gordon B. et al. published their research in Australian Journal of Chemistry in 1979 | CAS: 20733-10-2

4-Hydroxypyridazine (cas: 20733-10-2) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Quality Control of 4-Hydroxypyridazine

Proton NMR studies of protonation in pyridazin-3(2H)-one and 6-hydroxypyridazin-3(2H)-one was written by Barlin, Gordon B.;Fenn, M. David. And the article was included in Australian Journal of Chemistry in 1979.Quality Control of 4-Hydroxypyridazine This article mentions the following:

A 1H NMR study of protonation in pyridazin-3-ol and pyridazine-3,6-diol revealed that the processes are not simple and suggests that a mobile tautomeric equilibrium may be involved. In the experiment, the researchers used many compounds, for example, 4-Hydroxypyridazine (cas: 20733-10-2Quality Control of 4-Hydroxypyridazine).

4-Hydroxypyridazine (cas: 20733-10-2) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Quality Control of 4-Hydroxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

New learning discoveries about 20733-10-2

20733-10-2, 20733-10-2 4-Hydroxypyridazine 565900, apyridazine compound, is more and more widely used in various fields.

20733-10-2, 4-Hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Hydroxypyridazine (2.00 g, 20.8 mmol), ethyl 2-bromoacetate (5.21 g, 31.2 mmol) and K2CO3 (4.31 g, 31.2 mmol) were added to acetonitrile (30 mL).The reaction solution was concentrated under reduced pressure and purified ethyl acetate / petroleum etherEthyl 2-(pyridazin-4-yloxy)acetate (1.40 g, 7.69 mmol, 37.0%).

20733-10-2, 20733-10-2 4-Hydroxypyridazine 565900, apyridazine compound, is more and more widely used in various fields.

Reference：
Patent; Shenzhen Weixin Biological Technology Co., Ltd.; Yu Jindi; Lu Xianping; Li Zhibin; Xin Lijun; Zhu Jiangfei; Fu Chao; (67 pag.)CN108203438; (2018); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

New learning discoveries about 20733-10-2

20733-10-2, 20733-10-2 4-Hydroxypyridazine 565900, apyridazine compound, is more and more widely used in various fields.

20733-10-2, 4-Hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Hydroxypyridazine (2.00 g, 20.8 mmol), ethyl 2-bromoacetate (5.21 g, 31.2 mmol) and K2CO3 (4.31 g, 31.2 mmol) were added to acetonitrile (30 mL).The reaction solution was concentrated under reduced pressure and purified ethyl acetate / petroleum etherEthyl 2-(pyridazin-4-yloxy)acetate (1.40 g, 7.69 mmol, 37.0%).

20733-10-2, 20733-10-2 4-Hydroxypyridazine 565900, apyridazine compound, is more and more widely used in various fields.

Reference：
Patent; Shenzhen Weixin Biological Technology Co., Ltd.; Yu Jindi; Lu Xianping; Li Zhibin; Xin Lijun; Zhu Jiangfei; Fu Chao; (67 pag.)CN108203438; (2018); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

New learning discoveries about 20733-10-2

20733-10-2, 20733-10-2 4-Hydroxypyridazine 565900, apyridazine compound, is more and more widely used in various fields.

20733-10-2, 4-Hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Hydroxypyridazine (2.00 g, 20.8 mmol), ethyl 2-bromoacetate (5.21 g, 31.2 mmol) and K2CO3 (4.31 g, 31.2 mmol) were added to acetonitrile (30 mL).The reaction solution was concentrated under reduced pressure and purified ethyl acetate / petroleum etherEthyl 2-(pyridazin-4-yloxy)acetate (1.40 g, 7.69 mmol, 37.0%).

20733-10-2, 20733-10-2 4-Hydroxypyridazine 565900, apyridazine compound, is more and more widely used in various fields.

Reference：
Patent; Shenzhen Weixin Biological Technology Co., Ltd.; Yu Jindi; Lu Xianping; Li Zhibin; Xin Lijun; Zhu Jiangfei; Fu Chao; (67 pag.)CN108203438; (2018); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem