Category: 20698-04-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20698-04-8,3,6-Diiodopyridazine,as a common compound, the synthetic route is as follows.

To a solution of compound 2 (1.40 g, 4.22 mmol) in methanol (20 mL) was added CH3ONa (0.34 g, 6.33 mmol), and the mixture was stirred at 80C for 1 h. The reaction was quenched by addition of water (20 mL), then extracted with CH2Cl2 (10 mL x 3). The combined organic layer was dried over sodium sulfate, filtered, concentrated under reduced pressure and purified by silica gel column chromatography to give compound 3 (0.97 g, 97%) as a colored solid, mp 96 – 98C., 20698-04-8

The synthetic route of 20698-04-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yue, Qiming; Zhao, Yi; Hai, Li; Zhang, Tao; Guo, Li; Wu, Yong; Tetrahedron; vol. 71; 40; (2015); p. 7670 – 7675;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20698-04-8,3,6-Diiodopyridazine,as a common compound, the synthetic route is as follows.

0.50 mL (6.6 mmol) isopropanol are added to 289 mg (7.23 mmol) sodium hydride (60%) in 100 mL THF and the mixture is stirred for 30 min at rt. After that time, 2.0 g (6.0 mmol) 3,6-diiodo-pyridazine are added and the mixture is stirred for 14 h at rt and for 14 h at 50C. After that time, the mixture is poured into water and extracted with EtOAc. The organic layer is washed with water (2x) and dried over sodium sulphate. The solvent is removed in vacuo and the residue is purified by column chromatography (silicia gel; heptane: EtOAc gradient 0 to 50%).C7H9IN2O (M= 264.06 g/mol)ESI-MS: 265 [M+H]+ Rt (HPLC): 3.14 min (method P), 20698-04-8

20698-04-8 3,6-Diiodopyridazine 250383, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; NEUBAUER, Heike; NOSSE, Bernd; WO2012/32014; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

20698-04-8, 3,6-Diiodopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method C3-(6-lodo-pyridazin-3-yl)-9-methyl-9-aza-bicvclor3.3.1lnonane free base (Intermediate compound; JBP 18097-a)A mixture of 9-methyl-3,9-diazabicyclo[3.3.1]nonane (4.0 g, 28.5 mmol), 3,6-diiodopyridazine (9.5 g, 28.5 mmol), diisopropylethylamine (7.4 g, 57.0 mmol) and dioxane (50 ml) was stirred at 750C for 4 days. Aqueous sodium hydroxide (75 ml, 1 M) was added, dioxane was evaporated and the mixture was extracted twice with dichloromethane (2 x 75 ml). Chromatography on silica gel with dichloromethane, 10% methanol and 1% aqueous ammonia as solvent gave the title compound. Yield 4.61 g (47%). Mp. 163-166C., 20698-04-8

The synthetic route of 20698-04-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUROSEARCH A/S; WO2006/87306; (2006); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

20698-04-8, 3,6-Diiodopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In an argon atmosphere, a mixture of 3,6-diiodopyridazine (9.3 g), 4-(2-chlorobenzyl)piperidine-4-carbonitrile hydrochloride (8.36 g), potassium bicarbonate (8.42 g) and dehydrated DMF (40 mL) was stirred at 90C over weekend. The mixture was poured to water, followed by extraction with ethyl acetate. The organic layer was washed with water and saturated brine, dried over magnesium sulfate and then concentrated. The residue was crystallized from IPE-ethyl acetate to obtain the title compound (9.45 g). 1H NMR (300 MHz, DMSO-d6) delta 1.65-2.01 (4H, m), 2.92-3.07 (2H, m), 3.13 (2H, s), 4.28-4.53 (2H, m), 7.14 (1H, d, J = 9.5 Hz), 7.29-7.42 (2H, m), 7.46-7.54 (2H, m), 7.72 (1H, d, J = 9.4 Hz).

20698-04-8, As the paragraph descriping shows that 20698-04-8 is playing an increasingly important role.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; IMAMURA Keisuke; TOMITA Naoki; ITO Yoshiteru; ONO Koji; MAEZAKI Hironobu; NII Noriyuki; (123 pag.)EP3118200; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20698-04-8,3,6-Diiodopyridazine,as a common compound, the synthetic route is as follows.

Example 29 A mixture of 5.2 parts of 3,6-diiodopyridazine, 3.5 parts of 1-[3-(trifluoromethyl)phenyl]piperazine, 3.2 parts of sodium carbonate and 90 parts of N , N -dimethylacetamide was stirred and heated overnight at 70C. The reaction mixture was poured onto water. The precipitated product was filtered off and crystallized from 2-propanol, yielding 3.2 parts (48%) of 3-iodo-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-pyridazine; mp. 144.6C (compound 202)., 20698-04-8

20698-04-8 3,6-Diiodopyridazine 250383, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; EP156433; (1991); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

20698-04-8, 3,6-Diiodopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Cyano-6-(4-methylpiperazin-1-yl)pyridazine can be prepared from 6-(4-methylpiperazin-1-yl)-3-iodopyridazine (125 g) and cuprous cyanide (55.26 g) suspended in dimethylformamide (620 cc). 3-Cyano-6-(4-methylpiperazin-1-yl)pyridazine (52.1 g), melting at 149 C, is obtained. 3-Iodo-6-(4-methylpiperazin-1-yl)pyridazine can be obtained from 3,6-diiodopyridazine (158.5 g) and 4-methylpiperazine (120 g) suspended in methanol (1200 cc). 3-Iodo-6-(4-methylpiperazin-1-yl)pyridazine (138.7 g), melting at 149 C, is obtained., 20698-04-8

20698-04-8 3,6-Diiodopyridazine 250383, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Rhone-Poulenc Industries; US4110450; (1978); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20698-04-8,3,6-Diiodopyridazine,as a common compound, the synthetic route is as follows.

1.10. a Benzyl-(6-iodo-pyridazin-3-yl)-amine471 mg (10,8 mmol) sodium hydride (55%) are added at O0C under nitrogen atmosphere to a mixture of 1 ,084 ml (9,8 mmol) benzylamine and 25 ml dry DMF. The reaction mixture is stirred for one hour at room temperature. Then 3,26 g (9,8 mmol) 3,6-diiodo-pyridazine are added and the reaction mixture is stirred at 1000C for 18 hours. The reaction mixture is concentrated. Methylene chloride is added to the residue and the mixture is extracted with water. The organic phase is dried over sodium sulphate and concentrated. Purification is achieved by silica gel column chromatography with petrol ether/ EtOAc as eluent. Yield: 0,23 g (8% of theory),Rf value: 0.55 (silica gel, petrol ether/ EtOAc = 1 :1 ), 20698-04-8

The synthetic route of 20698-04-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

20698-04-8, 3,6-Diiodopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method CS-CG-lodo-pyridazin-S-vD-Q-methyl-Q-aza-bicvclofS.S.I Inonane free base(Intermediate Compound) A mixture of 9-methyl-3,9-diazabicyclo[3.3.1]nonane (4.0 g, 28.5 mmol), 3,6-diiodopyridazine (9.5 g, 28.5 mmol), diisopropylethylamine (7.4 g, 57.0 mmol) and dioxane (50 ml) was stirred at 75C for 4 days. Aqueous sodium hydroxide (75 ml, 1 M) was added, dioxane was evaporated and the mixture was extracted twice with dichloromethane (2 x 75 ml). Chromatography on silica gel with dichloromethane, 10% methanol and 1 % aqueous ammonia as solvent gave the title compound. Yield 4.61 g (47%). Mp 163-166C.

20698-04-8, 20698-04-8 3,6-Diiodopyridazine 250383, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; NEUROSEARCH A/S; WO2009/150139; (2009); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

20698-04-8, 3,6-Diiodopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

I II.5. a 3-lodo-6-phenethyl-pyridazine To 200 ml (100 mmol) 0,5 M phenylethylzincbromid solution in THF are added dropwise a mixture of 26,55 g (80 mmol) 3,6 Diiodopyridazine and 4,622 g (4 mmol) Tetrakis(triphenylphosphine) palladium(O) in 100 ml abs. THF. The reaction mixture is stirred for 3 hours at room temperature. Then the mixture is poured in saturated sodium hydrogencarbonate solution and ethyl acetate is added. The mixture is filtered over Celite and the phases are separated. The organic phase is dried over sodium sulphate. Purification is achieved by chromatography (silica gel, methylene chloride/ ethyl acetate= 19:1 ). Yield: 13,97 g (56 % of theory),Rf value: 0.47 (silica gel, methylene chloride/ethyl acetate= 19:1 )EII mass spectrum: m/z = 31 1 [M+H]+

20698-04-8, The synthetic route of 20698-04-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem