Category: 20375-65-9

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Synthesis of N-alkyl-N-methyl amino acids. Scope and limitations of base-induced N-alkylation of Cbz-amino acids

The reaction of N-benzyloxycarbonyl derivatives of aliphatic amino acids with NaH/alkyl iodides gave the corresponding N-Cbz-N-alkyl derivatives in good to high yields. The scope and limitations of this simple N-alkylation reaction were investigated as a convenient and flexible attempt to prepare unsymmetrically N,N-diprotected alpha-amino acids. The procedure is based on the N-alkylation of N-carbamoyl amino acids, a one-pot deprotection/protection sequence without extensive purification of the products. Protection of the carboxyl function is not required while the starting materials are inexpensive and commercially available.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2748 – PubChem

 

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New preorganized gamma-amino acids as foldamer building blocks

An asymmetric synthesis of two new diastereomeric gamma-amino acids is described. Both molecules contain a cyclohexyl ring to limit conformational flexibility about the Calpha-Cbeta bond; they differ in having cis vs trans stereochemistry on the ring. Residues derived from the cis gamma isomer are shown to support helical secondary structures in alpha/gamma-peptide oligomers.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2634 – PubChem

 

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Synthesis of phosphoryl-tethered beta-cyclodextrins and their molecular and chiral recognition thermodynamics

Two novel phosphoryl-bridged bis- and tris(beta-cyclodextrin)s of different tether lengths, i.e., bis[m-(N-(6-cyclodextryl)-2-aminoethylaminosulfonyl)phenyl]-m- (chlorosulfonyl)phenylphosphine oxide (5) and tris[m-(N-(6-cyclodextryl)-8-amino-3,6-diazaoctylaminosulfonyl)phenyl] phosphine oxide (6), have been synthesized by reactions of 6-oligo(ethylenediamino)-6-deoxy-beta-cyclodextrins with tris[m-(chlorosulfonyl)phenyl]phosphine oxide. The complex stability constants (Ks), standard molar enthalpy (deltaH), and entropy changes (deltaS) were determined at 25 C for the inclusion complexation of phosphoryl-modified bis- and tris-cyclodextrins (5 and 6, respectively), mono [6-O-(ethoxyhy-droxyphosphoryl)]-beta-cyclodextrin (2), mono [6-O-(diethylamino-ethoxyphosphoryl)]-beta-cyclodextrin (3), and mono [6-O-(diphenoxyphosphoryl)]-beta-cyclodextrin (4) with representative alicyclic and N-Cbz-D/L-alanine guests in 0.1 M phosphate buffer solution at pH 7.2 by means of titration microcalorimetry. The thermodynamic parameters obtained indicate that the charge-dipole interaction between the phosphoryl moiety and the negatively charged guests, as well as the conformational difference of modified beta-cyclodextrins in aqueous solution, significantly contribute to the inclusion complexation and the enhanced chiral discrimination. The interactions and binding modes between the hosts and chiral guests were further studied by two-dimensional NMR spectroscopy to elucidate the influence of the structural features of hosts on their increased chiral recognition ability and to establish the correlation between the conformation of the resulting complexes and the thermodynamic parameters obtained.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2688 – PubChem

 

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Complexation of chiral di (N-Protected alpha-Amino)-beta-diketones with some transition metals

Chiral Di (N-protected a-amino)-b-diketones and its transition metal complexes have been synthesized. Di(N-protected a-amino)-b- diketones were prepared by reaction of activation of N-protected- a-amino acids (imidazolide) with a-diazoketones derived from natural amino acids in presence of lithium diisopropyl amid in tetrahydrofuran as a solvent at -78 C and treatment the product with rhodium acetate to remove diazo group. The synthesized compounds were characterized by analytical techniques viz: IR, NMR and elemental analysis. The thermal stability of the newly synthesized metal complexes have been studied.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2735 – PubChem

 

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Photochemical transformations of diazocarbonyl compounds: Expected and novel reactions

Photochemical reactions of diazocarbonyl compounds are well positioned in synthetic practice as an efficient method for ring contraction and homologation of carboxylic acids and as a carbene generation method. However, interpretation of the observed transformations of diazo compounds in electronically excited states is incomplete and requires a careful study of the fine mechanisms of these processes specific to different excited states of diazo compounds resorting to modern methods of investigation, including laser technology. The review is devoted to analysis of new data in the chemistry of excited states of diazocarbonyl compounds.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2627 – PubChem

 

Reference of 20375-65-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 20375-65-9, molcular formula is C10H7ClN2, introducing its new discovery.

Convenient synthesis of acetaminophen analogues containing alpha-amino acids and fatty acids via their mixed carbonic carboxylic anhydrides in aqueous organic solvent

Acetaminophen analogues containing alpha-amino acid and fatty acids were easily synthesized in 77-99% yields from the corresponding mixed carbonic carboxylic anhydrides of alpha-amino acid and fatty acids using aniline derivatives in aqueous MeCN.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2663 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 20375-65-9, name is 3-Phenyl-6-chloropyridazine, introducing its new discovery. Quality Control of 3-Phenyl-6-chloropyridazine

Chiral recognition thermodynamics of beta-cyclodextrin: The thermodynamic origin of enantioselectivity and the enthalpy-entropy compensation effect

The complex stability constant (K), standard free energy (DeltaG), enthalpy (DeltaH), and entropy (DeltaS) for the 1:1 inclusion complexation of 43 enantiomeric pairs of chiral guests with beta-cyclodextrin at 25 C have been determined by microcalorimetry. The overall complexation thermodynamics are related to variations in the structure of the cyclic and acyclic guest, including its aromatic or aliphatic nature, the chain length, branching, flexibility, charge, and incorporated oxygen atom. The differences in the thermodynamic parameters due to the chirality are comprehensively discussed in terms of the stereochemistry, skeleton, chain length, and functional groups of the guest, and the mode of penetration upon inclusion complexation. The enthalpy-entropy compensation plot, using the differential thermodynamic parameters (DeltaDeltaHand DeltaTDeltaSat 298.15 K) for the chiral recognition equilibrium, gave an excellent straight line of unit slope, from which the isokinetic, or isoenantiodifferentiating, temperature was calculated as 25 C for this chiral recognition system using a beta-cyclodextrin host.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2727 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C10H7ClN2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 20375-65-9, name is 3-Phenyl-6-chloropyridazine. In an article£¬Which mentioned a new discovery about 20375-65-9

NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR SELECTIVE ANTAGONISTS

The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2569 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C10H7ClN2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 20375-65-9, Name is 3-Phenyl-6-chloropyridazine, molecular formula is C10H7ClN2

A synthetic receptor for the Cbz-L-Ala-L-Ala-OH dipeptide sequence

A novel bowl-shaped macrobicyclic receptor has been prepared and is a particularly strong and selective receptor for Cbz-L-Ala-L-Ala-OH(-DeltaG(ass) = 25 kJ mol-1 at 293 K in CDCL3).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2646 – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of 3-Phenyl-6-chloropyridazine. Introducing a new discovery about 20375-65-9, Name is 3-Phenyl-6-chloropyridazine

Chlamydocin-hydroxamic acid analogues as histone deacetylase inhibitors

Chlamydocin-hydroxamic acid analogues were designed and synthesized as histone deacetylase (HDAC) inhibitors based on the structure and HDAC inhibitory activity of chlamydocin and trichostatin A. Chlamydocin is a cyclic tetrapeptide containing an epoxyketone moiety in the side chain that makes it an irreversible inhibitor of HDAC. We replaced the epoxyketone moiety of chlamydocin with hydroxamic acid to design potent and reversible inhibitors of HDAC. In addition, a number of amino-cycloalkanecarboxylic acids (Acc) are introduced instead of the simple amino-isobutric acid (Aib) for a variety of the series of chlamydocin analogues. The compounds synthesized were tested for HDAC inhibitory activity and the results showed that many of them are potent inhibitors of HDAC. The replacement of Aib residue of chlamydocin with an aromatic amino acid enhances the in vivo and in vitro inhibitory activity. We have carried out circular dichroism and molecular modeling studies on chlamydocin-hydroxamic acid analogue and compared it with the solution structure of chlamydocin.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2712 – PubChem