Category: 20375-65-9

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THE CHEMISTRY OF PEPTIDES RELATED TO METABOLITES OF TRICHODERMA SPP. 2. AN IMPROVED METHOD OF CHARACTERIZATION OF PEPTIDES OF 2-METHYLALANINE

4-Chlorobenzoylazide reacts with amino acid and peptide esters to give the 4-chlorobenzoyl derivatives in 60-90percent yield, at room temperature, without measurable racemization.The reaction also proceeds smoothly with hindered amines such as methyl 2-methylalaninate and with secondary amines, e.g. methyl L-prolyl-L-valinate.Ten examples of the reaction are reported with peptides, synthesized for the purpose, that might be accessible from hydrolysates of the numerous fungal metabolites now known, which contain a high proportion of 2-methylalanine.The derivatives of di-, tri-, tetra-, and pentapeptides were highly crystalline, with sharp melting points, and could be detected and integrated in the effluent from chromatography columns at about the 10-ng level.This simple method of derivatization might be usefully applied to the resolution of discrepancies in the physical properties of ostensibly the same 2-methylalanyl peptide prepared in different laboratories.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2740 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 3-Phenyl-6-chloropyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 20375-65-9, Name is 3-Phenyl-6-chloropyridazine, molecular formula is C10H7ClN2

Three-step synthesis of cyclopropyl peptidomimetics

An efficient approach to novel cyclopropyl peptidomimetics has been developed. The synthetic route involves a cyclopropanation using ethyl (dimethylsulfuranylidene)acetate (EDSA) as the key step and affords a cyclopropyl peptidomimetic core in three steps from protected amino acid Weinreb amides.

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Potassium trimethylsilanolate induced cleavage of 1,3-oxazolidin-2- and 5-ones, and application to the synthesis of (R)-salmeterol.

A convenient and efficient method for the cleavage of 1,3-oxazolidin-5-ones and 1,3-oxazolidin-2-ones utilising potassium trimethylsilanolate in tetrahydrofuran is described. The benzyloxycarbonyl-protecting group is readily removed under the reaction conditions, whereas the N-benzoyl group is stable. A synthesis of (R)-salmeterol exploiting the 2-oxazolidinone ring as a protecting group for the ethanolamine moiety is also described.

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Pyridazine | C4H4N2606 – PubChem

 

Related Products of 20375-65-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 20375-65-9, 3-Phenyl-6-chloropyridazine, introducing its new discovery.

Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3- phenylpropyl)-D-alaninamide

A number of O- and N-alkylated derivatives of the antinociceptive, orally active, mu-opioid-selective truncated enkephalin analog L-2,6- dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide (2,SC-39566) were synthesized to explore the structure-activity relationships of the series. The parent molecule is quite forgiving of substitution on the tyrosyl phenolic moiety and on the alanyl nitrogen. The tyrosyl and (phenylpropyl)amide NH sites, however, appear to be critical to interactions with the receptor, for even modest changes at these sites cause great loss of binding potency.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2722 – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of 3-Phenyl-6-chloropyridazine. Introducing a new discovery about 20375-65-9, Name is 3-Phenyl-6-chloropyridazine

The marine-derived halipeptins A (1a) and D (1d) and their analogues 3a, 3d and 4a, 4d were synthesized starting from building blocks 10, 13, 14a or 14d, 15, and 16. The first strategy for assembling the building blocks, involving a macrolactamization reaction to form the 16-membered ring hydroxy thioamide 52d as a precursor, furnished the epi-isoleucine analogue (4d) of halipeptin D, whereas a second approach involving thiazoline formation prior to macrolactamization led to a mixture of halipeptins A (1a) and D (1d) and their analogues 3a, 3d (epimers at the indicated site) and 4a, 4d (epimers at the indicated site). The same route starting with D-Ala resulted in the exclusive formation of the epimeric halipeptin D analogue 3d. The synthesized halipeptins, together with the previously constructed oxazoline analogues 5d and 6d, were subjected to biological evaluation revealing anti-inflammatory properties for 1a, 1d, and 6d while being noncytotoxic against human colon cancer cells (HCT-116).

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 20375-65-9, name is 3-Phenyl-6-chloropyridazine, introducing its new discovery. Application In Synthesis of 3-Phenyl-6-chloropyridazine

Following the development of raltitrexed, the synthesis of nonpolyglutamatable inhibitors of TS that do not use the reduced folate carrier (RFC) for cellular entry should provide compounds which overcome mechanisms of resistance to folate-based inhibitors of TS that are associated with decreased/altered folylpolyglutamate synthetase (FPGS) expression and/or an impaired RFC. Examination of a computer graphics model of the humanized Escherichia coli TS enzyme with quinazoline inhibitors of TS, such as 1 bound in the active site of the enzyme, suggested that conformational restriction introduced by bridging the C9 with C7 to form a pentacycle may be beneficial for binding to TS. That led to the synthesis of a series of potent cyclopenta[g]quinazoline-based inhibitors of the enzyme in which the glutamyl residue associated with classical antifolates was replaced with a variety of glutamate-derived ligands; the most potent inhibitor being the L-Glu-gamma-D- GluT(alpha) derivative 7j. In the mouse L1210:1565 cell line (mutant RFC), the majority of these compounds had activity equal or only slightly greater compared with the parental L1210 cell line, indicating a reduced dependence on the RFC for cellular uptake in the L1210 cell line.

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2-Cyanosteroids

The invention relates to novel 2-cyanosteroids of Formula I which are useful for the induction of menses and the termination of pregnancy.

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Pyridazine – Wikipedia,
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Electric Literature of 20375-65-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 20375-65-9, Name is 3-Phenyl-6-chloropyridazine,introducing its new discovery.

A New Route toward 4-Substituted Pyrazino[2,1-b]quinazoline-3,6-dione Systems. Total Synthesis of Glyantrypine

Treatment of sodium N-(o-azidobenzoyl)aminoacylglycinates 8 with acetic anhydride afforded 1-acetyl-4-(o-azidobenzoyl)-2,5-piperazinediones 7, with complete retention of the stereochemistry. The intramolecular aza Wittig reactions of compounds 7 in the presence of tributylphosphine followed by deacetylation gave 1,2-unsubstituted pyrazino[2,1-b]quinazoline-3,6-diones 1. This route was adapted to the synthesis of both enantiomers of the alkaloid glyantrypine.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2605 – PubChem

 

20375-65-9, Name is 3-Phenyl-6-chloropyridazine, belongs to pyridazine compound, is a common compound. Application In Synthesis of 3-Phenyl-6-chloropyridazineIn an article, once mentioned the new application about 20375-65-9.

Baker’s yeast reduction of N-protected methyl 4-amino-3-oxobutanoates and 3-oxopentanoates

Baker’s yeast reduction of N-tert-butoxycarbonyl (Boc) or N-benzyloxycarbonyl (Cbz) protected methyl 4-amino-3-oxopentanoates 4b-e and 4-amino-3-oxobutanoates 7a,b stereoselectively afforded the erythro-hydroxy esters 5b-e and (R)-hydroxy esters 8a,b, respectively. The resulting N-protected methyl (R)-4-amino-3-hydroxybutanoate (8) was converted into the biologically active substances, sperabillin C 1c and (R)-GABOB [(R)-4-amino-3-hydroxybutanoic acid, 2].

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Pyridazine – Wikipedia,
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Synthesis and characterization of chiral di(N-protected-alpha-amino) diazo-beta-diketones from alpha-diazoketones and imidazolides derived from amino acids

Di(N-protected-alpha-amino)diazo-beta-diketones were prepared by the reaction of activated N-protected-alpha-amino acids (imidazolides) with alpha-diazoketones, derived from natural amino acids, in the presence of lithium diisopropylamide in tetrahydrofuran as the solvent at -78 C.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2736 – PubChem