Category: 19064-67-6

19064-67-6, 6-Chloro-3-hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 255 2-benzyl-6-chloro-2H-pyridazine-3-one 6-chloro-2H-pyridazine-3-one (3.50 g) was dissolved in DME (130 mL). To this solution, cesium carbonate (17.5 g) was added and the mixture was stirred at room temperature for 15 min in an argon atmosphere. Subsequently, benzyl bromide (4.00 mL) was added and the mixture was stirred at room temperature for 3.5 hours. The insoluble inorganic residue was removed by filtration and the filtrate was concentrated. Water was then added to the residue and the mixture was extracted with ethyl acetate, washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated and the resulting crystals were recrystallized from ethyl acetate/petroleum ether to afford the title compound as a pale yellow powder (4.94 g). 1H NMR (200 MHz, CDCl3) delta 7.28-7.47 (5H, m), 7.15 (1H, d, J=9.6 Hz), 6.90 (1H, d, J=9.6 Hz), 5.25 (2H, s). 13C NMR (50 MHz, CDCl3) delta 158.77, 137.43, 135.48, 133.66, 132.20, 128.86, 128.67, 128.20, 55.43

19064-67-6, As the paragraph descriping shows that 19064-67-6 is playing an increasingly important role.

Reference£º
Patent; Kohno, Yasushi; Adams, David Roger; Ando, Naoki; US2008/207902; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-67-6,6-Chloro-3-hydroxypyridazine,as a common compound, the synthetic route is as follows.

To a solution of 6-chloropyridazin-3(2H)-one (0.35 g, 2.68 mmol) in DMF (10 mL) was added K2CO3 (0.93 g, 6.70 mmol) and methyl iodide (0.20 mL, 3.22 mmol). The resulting mixture was stirred at 25 C for 1 h. To the reaction mixture was added ice cold water (30 mL) and the mixture was extracted with ethyl acetate (2 x 50 ml). The combined organic layers were washed with brine (30 mL), dried over sodium sulfate and distilled under reduced pressure to obtain Intermediate 107 (0.25 g, 56.10%) as an off white solid.1H NMR (400 MHz, CDCl3) delta ppm 3.75 (s, 3 H), 6.92 (d, J = 9.76 Hz, 1 H), 7.19 (d, J = 9.76 Hz, 1 H). LCMS (Method-D): retention time 0.66 min, [M+1] 145.2.

19064-67-6, As the paragraph descriping shows that 19064-67-6 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-67-6, 6-Chloro-3-hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A) 6-Chloro-2-(2-dimethylamino-ethyl)-2H-pyridazin-3-one:To a solution of 6-chloro-pyridazin-3-one (500 mg, 3.83 mmol) in 5 mL N,N- dimethylformamide was added 2-dimethylaminoethyl chloride hydrochloride (828 mg, 5.75 mmol), potassium carbonate (1.59 g, 11.5 mmol) and sodium iodide (632 mg, 4.21 mmol). The mixture was stirred over night at 65 0C. The solvent was evaporated. The crude product was purified by preparative HPLC using a gradient of acetonitrile / 5 % acetonitrile-water phase containing 0.1 M ammonium acetate, to give 174 mg of the desired sub-title product as light brown solids after freeze drying (22 % yield). 1H NMR (400 MHz, methanol-d4 as solvent and internal reference) delta (ppm) 2.35 (s, 6H), 2.82 (t, 2H, J = 6.4 Hz), 4.26 (t, 2H, J = 6.5 Hz), 6.9S (d, IH, J = 9.7 Hz), 7.44 (d, IH. J = 9.7 Hz)., 19064-67-6

The synthetic route of 19064-67-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2007/8144; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-67-6,6-Chloro-3-hydroxypyridazine,as a common compound, the synthetic route is as follows.

To a 250-mL round-bottom flask was placed a solution of 6- chloro-2,3-dihydropyridazin-3-one (1.87 g, 14.33 mmol) and 2-chloro-N-[4- (trifluoromethyl)phenyl]propanamide (3 g, 11.92 mmol, as prepared in the previous step) in acetone (60 mL) then K2CO3 (4.9 g, 35.20 mmol) was added. The reaction was stirred at 60C for 16 h, then the solids were filtered out and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography eluting with EtO Ac/petroleum ether (1:20 up to 1: 1) affording 1.4 g (34%) of the title compound as a white solid. Mass Spectrum (LCMS, ESI pos): Calcd. for (0182) Ci4H12ClF3N302+: 346.1 (M+H); Found: 346.1. H NMR (300 MHz, DMSO-cfe): delta 10.62 (s, 1H), 7.80-7.77 (d, / = 8.4 Hz, 2H), 7.70-7.62 (m, 3H), 7.12-7.08 (d, / = 9.9 Hz, 1H), 5.43-5.34 (q, / = 7.2 Hz, 1H), 1.61-1.59 (d, / = 7.2 Hz, 3H)., 19064-67-6

19064-67-6 6-Chloro-3-hydroxypyridazine 252828, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; PROTEOSTASIS THERAPEUTICS, INC.; PARKS, Daniel; MUNOZ, Benito; (66 pag.)WO2018/81378; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem