Category: 19064-65-4

Electric Literature of 19064-65-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.19064-65-4, Name is 3-Methoxypyridazine, molecular formula is C5H6N2O. In a Article£¬once mentioned of 19064-65-4

Fossil redox-conditions influence organic matter composition in loess paleosols

The soil memory recorded in paleosols of loess-paleosol sequences is an important contributor to our understanding of past climatic conditions. Molecular proxies based on the organic matter preserved in paleosols form an essential part of this record, but the long-term preservation of SOM is poorly understood, especially for sediment traps and slope profiles. This paper addresses the composition of organic material from the Early Weichselian A-horizons of the Rocourt paleosol, a major paleostratigraphic marker for the Eemian and Early Weichselian in Western Europe. NaOH-extractable organic matter from an exceptionally thick Rocourt profile in the Kesselt Quarry (Belgian Loess Belt) was analyzed by pyrolysis-Gas Chromatography/Mass Spectrometry (pyrolysis-GC/MS) and the results evaluated against paleopedological data. The molecular composition of the organic matter at Kesselt was compared with reference samples from two nearby quarries (including the type locality at Veldwezelt-Hezerwater), and to a sample from the contemporary Nussloch sequence in Germany. The SOM composition found at the four sites indicated a large content of microbial matter and was dominated by?carbohydrates and N compounds, many of which were not reported before from SOM pyrolysates. Differences in the molecular composition between samples, both within profiles and between sites, coincided with differences in landscape position (slope-shoulder-plateau) and fossil redox conditions (surface gleys). Samples form drier and more upland situations contained more burnt material, while samples from slope profiles and surface gleys contained even more microbial material, in particular chitin. Results therefore suggest that the admixture of microbial SOM is considerable in loess-paleosols and that differences in edaphic conditions (in particular slope position and soil moisture) and occurrence of wildfires are important for the long-term preservation of SOM. These should therefore be considered when interpreting biogeochemical proxies.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N272 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. name: 3-Methoxypyridazine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 19064-65-4

N-phenyl-4-pyrazolo[1,5-6]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacy

Glycogen synthase kinase 3 regulates glycogen synthase, the rate-determining enzyme for glycogen synthesis. Liver and muscle glycogen synthesis is defective in type 2 diabetics, resulting in elevated plasma glucose levels. Inhibition of GSK-3 could potentially be an effective method to control plasma glucose levels in type 2 diabetics. Structure-activity studies on a N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine series have led to the identification of potent and selective compounds with good cellular efficacy. Molecular modeling studies have given insights into the mode of binding of these inhibitors. Since the initial leads were also potent inhibitors of CDK-2/CDK-4, an extensive SAR was performed at various positions of the pyrazolo[1,5-b] pyridazin core to afford potent GSK-3 inhibitors that were highly selective over CDK-2. In addition, these inhibitors also exhibited very good cell efficacy and functional response. A representative example was shown to have good oral exposure levels, extending their utility in an in vivo setting. These inhibitors provide a viable lead series in the discovery of new therapies for the treatment of type 2 diabetes.

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C5H6N2O, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 19064-65-4, name is 3-Methoxypyridazine. In an article£¬Which mentioned a new discovery about 19064-65-4

Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5- b]pyridazines for the Treatment of Human African Trypanosomiasis

From a high-throughput screen of 42 444 known human kinases inhibitors, a pyrazolo[1,5-b]pyridazine scaffold was identified to begin optimization for the treatment of human African trypanosomiasis. Previously reported data for analogous compounds against human kinases GSK-3beta, CDK-2, and CDK-4 were leveraged to try to improve the selectivity of the series, resulting in 23a which showed selectivity for T. b. brucei over these three human enzymes. In parallel, properties known to influence the absorption, distribution, metabolism, and excretion (ADME) profile of the series were optimized resulting in 20g being progressed into an efficacy study in mice. Though 20g showed toxicity in mice, it also demonstrated CNS penetration in a PK study and significant reduction of parasitemia in four out of the six mice.

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Application of 19064-65-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 19064-65-4, Name is 3-Methoxypyridazine, molecular formula is C5H6N2O. In a Patent£¬once mentioned of 19064-65-4

COMPOSITIONS AND METHODS FOR MODULATING FXR

The present invention relates to compounds of Formula (I), a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesiod X receptors (FXR).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 19064-65-4. In my other articles, you can also check out more blogs about 19064-65-4

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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-65-4,3-Methoxypyridazine,as a common compound, the synthetic route is as follows.

Step 1: A mixture of 3-methoxypyridazine (12.0 mL, 130 mmol) and oxirane-2,2,3,3- tetracarbonitrile (20 g, 140 mmol) in THF (240 mL) was stirred at 0 oC for 2 h and at 4 oC for 40 h. The reaction was concentrated to afford crude dicyano(3-methoxypyridazin-1-ium-1- yl)methanide as a solid, which was taken to the next step without further purification. 1H NMR (DMSO-d6, 400 MHz): delta 8.56 (d, J = 6.0 Hz, 1H), 7.94 (m, 1H), 7.14 (d, J = 9.2 Hz, 1H), 3.97 (s, 3H)., 19064-65-4

19064-65-4 3-Methoxypyridazine 292493, apyridazine compound, is more and more widely used in various fields.

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Patent; MERCK SHARP & DOHME CORP.; LIM, Jongwon; ALTMAN, Michael, D.; BRUBAKER, Jason, D.; GIBEAU, Craig, R.; (94 pag.)WO2016/144847; (2016); A1;,
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Pyridazine | C4H4N2 – PubChem

 

19064-65-4, 3-Methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reagent 53-Methoxy-4-(tributylstannyl)pyridazine2,2,6,6-Tetramethylpiperidine (10.4 mL, 61.51 mmol) in ether (125 mL) was cooled to -30 C. and treated with n-BuLi (24.6 mL, 61.51 mmol). The reaction solution was warmed to room temperature for 30 minutes, and then cooled to -75 C. 3-Methoxypyridazine (3.10 g, 26.75 mmol) in ether (10 mL) was added slowly at -75 C. After ten minutes, tributylchlorostannane (10.45 g, 32.09 mmol) was added all at once and stirred at -75 C. for another forty-five minutes. The reaction was queched with a mixture of wet ether (50 mL)/saturated NH4Cl (50 mL), warmed to RT, diluted with ether (1000 mL) and washed with half-saturated NH4C twice The organic layer was dried through MgSO4, filtrated and evaporated to dry to give a yellow oil. The crude material was added to a silica gel column and was eluted with 0-20% ethyl acetate in hexane to give a blue liquid (2.09 g, 19.58% yield) as the title compound. 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 8.68 (d, J=4.2 Hz, 1 H) 7.43 (d, J=4.2 Hz, 1 H) 4.09 (s, 3 H) 1.44-1.57 (m, 6 H) 1.31 (sextet, J=7.3 Hz, 6 H) 0.99-1.23 (m, 6 H) 0.88 (t, J=7.2 Hz, 8 H. MS APCI, m/z=397/399/401 (M+H). HPLC 4.04 min.

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Patent; ASTRAZENECA AB; US2008/318943; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

19064-65-4, 3-Methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

b) 3-Methoxy-4-(tributylstannyl)pyridazine n-Butyllithium (7.1 mL of a 2.5 M solution in hexanes, 17.75 mmol) was slowly added (0.2 mL/min) to a solution of 2,2,6,6-tetramethylpiperidine (3 mL, 17,75 mmol) in dry diethyl ether (16 mL) at -30 ?C under argon atmosphere. The reaction mixture was stirred at 0 ?C for 30 minutes before being cooled down to -78 ?C and a solution of 3-methoxypyridazine (0.85 g, 7.72 mmol) in dry diethyl ether (4 mL) was slowly added (0.03 mL/min). The reaction mixture was stirred at this temperature for 10 additional minutes before the addition of tributylchlorostannane (2.5 mL, 9.22 mmol). After stirring at -78 ?C for 45 minutes, a mixture of diethyl ether and aqueous saturated solution of ammonium chloride (15 mL/15 mL) was added and the temperature was allowed to warm up to room temperature. Additional diethyl ether (300 mL) was then added to the mixture and the organic layer was separated, washed with saturated aqueous solution of ammonium chloride, dried over magnesium sulphate and the solvent removed under reduced pressure. The residue was purified by flash chromatography (100% hexanes to 1:1 hexanes/diethyl ether) to give the title compound (0.31 g, 10%) as a pale yellow oil. 1H-NMR delta (300 MHz, CDCl3): 0.88 (t, 9H), 1.03 – 1.19 (m, 6H), 1.23 – 1.40 (m, 6H), 1.43 – 1.61 (m, 6H), 4.09 (s, 3H), 7.44 (d, 1H), 8.69 (d, 1H).

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Reference£º
Patent; Almirall, S.A.; EP2463289; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem