Category: 19064-64-3

19064-64-3, 3,6-Dichloro-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of compound 3,6-dichloro-4-methylpyridazine (20.0 g, 122.7 mmol) and ammonium hydroxide in water (86.60 g, 245 mmol) was refluxed for about 30 h. The mixture was concentrated and used in the next step without purification, 19064-64-3

The synthetic route of 19064-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

To a suspension of 10 g (61 .4 mmol) 3,6-dichloro-4-methylpyridazine in 33 mL ethanol were added 33.3 mL (6750 mmol) of an aqueous ammonia solution (26% v/v). The mixture was heated in an autoclave (Berghof RHS175) to 120′ C/20 bar over night. After cooling to room temperature, the solvent was evaporated to give 12 g of a crude material which was used directly in step 2.

19064-64-3, The synthetic route of 19064-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER INTELLECTUAL PROPERTY GMBH; KNUT, Eis; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark; BOeMER, Ulf; GUeNTHER, Judith; FANGHAeNEL, Joerg; KORR, Daniel; WO2012/163942; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-64-3, 3,6-Dichloro-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 3,6-Dichloro-4-methyl-pyridazine (3.0 g, 18.40 mmol) in Ammonia (28-30% ; 150 ml_) was heated at 130 C in a pressurised reaction vessel for 16 hrs. The reaction mixture was cooled to ambient temperature and extracted with dichloromethane (10 x 100 ml.) The organic layers were combined, dried (MgSO4), filtered and concentrated to give a mixture of the titled compounds (853 mg; 32%). LCMS: (Method A) RT = 0.45 min; m/z = 144 [M+H]+.1H NMR: (400 MHz, DMSO-d6) delta 2.07 (s, 3H), 2.18 (s, 3H), 6.47 (bs, 2H), 6.49 (bs, 2H), 6.74 (s, 1H), 7.31 (s, 1H).

19064-64-3, 19064-64-3 3,6-Dichloro-4-methylpyridazine 87923, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; VERNALIS (R&D) LTD.; WO2009/109743; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

PREPARATION 16; 3-Bromo-6-chloro-7-methylimidazo[1,2- )]pyridazine a) 6-Chloro-5-methylpyridazin-3-amine (+ 6-chloro-4-methylpyridazin-3-amine) Ammonia (32% solution in water, 54 mL) was added to a solution of 3,6-dichloro-4- methylpyridazine (5.0 g, 30.67 mmol) in ethanol (25 mL) in a sealed tube. The resulting mixture was stirred at 100 C for 70 hours, cooled down and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (3:2 hexanes/ethyl acetate to 100% ethyl acetate) to yield the title compound (3.8 g, 57%) as a mixture of two isomers which was used in the next step without further purification.LRMS (m/z): 144 (M+1)+.

19064-64-3, 19064-64-3 3,6-Dichloro-4-methylpyridazine 87923, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ALMIRALL,S.A.; GONZALEZ RODRIGUEZ, Jacob; VIDAL JUAN, Bernat; VIDAL GISPERT, Laura; BACH TANA Jordi; WO2012/69202; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

Step 9.1. 6-Chloro-4-methylpyridazin-3-ylamine and 6-chloro-5-methylpyridazin-3-ylamine A mixture of 50.0 g (307 mmol) of 3,6-dichloro-4-methylpyridazine in 170 ml of aqueous ammonia (30%) is heated at 120 C. for 16 h in a steel reactor at the internal pressure of bar.The reactor is cooled and the reaction mixture is poured into 200 ml of water. The solid formed is isolated by filtration and dried under vacuum, to give 38.5 g of a mixture containing approximately 45% of 6-chloro-4-methylpyridazin-3-ylamine (CAS 64068-00-4) and 55% of 6-chloro-5-methylpyridazin-3-ylamine (CAS 66346-87-0).1H NMR (CDCl3) delta: 7.20 and 6.75 (2s, 1H): (d, 0.55H), 4.9 (sl, 2H), 2.40 and 2.25 (2s, 3H) ppm., 19064-64-3

As the paragraph descriping shows that 19064-64-3 is playing an increasingly important role.

Reference£º
Patent; SANOFI-AVENTIS; US2011/312934; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

PREPARATION 16; 3-Bromo-6-chloro-7-methylimidazo[1,2- )]pyridazine a) 6-Chloro-5-methylpyridazin-3-amine (+ 6-chloro-4-methylpyridazin-3-amine) Ammonia (32% solution in water, 54 mL) was added to a solution of 3,6-dichloro-4- methylpyridazine (5.0 g, 30.67 mmol) in ethanol (25 mL) in a sealed tube. The resulting mixture was stirred at 100 C for 70 hours, cooled down and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (3:2 hexanes/ethyl acetate to 100% ethyl acetate) to yield the title compound (3.8 g, 57%) as a mixture of two isomers which was used in the next step without further purification.LRMS (m/z): 144 (M+1)+., 19064-64-3

As the paragraph descriping shows that 19064-64-3 is playing an increasingly important role.

Reference£º
Patent; ALMIRALL,S.A.; GONZALEZ RODRIGUEZ, Jacob; VIDAL JUAN, Bernat; VIDAL GISPERT, Laura; BACH TANA Jordi; WO2012/69202; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

A suspension of 3,6-dichloro-4-methyl-pyridazine (3 g, 18.40 mmol) in concentrated ammonia (20 mL, 1.057 mol) in a sealed vessel was heated to 130 C for 15 h. After cooling to rt, it was diluted with water and filtered. The solid was dried under reduced pressure and used directly in the next step (2.2 g). NMR showed it contained two isomers; 6-chloro-4-methyl-pyridazin-3-amine and 6-chloro-5-methyl-pyridazin-3-amine in about 1:1.8 ratio., 19064-64-3

The synthetic route of 19064-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; FARMER, Luc J.; FOURNIER, Pierre-Andre; LESSARD, Stephanie; LIU, Bingcan; ST-ONGE, Miguel; STURINO, Claudio; SZYCHOWSKI, Janek; YANNOPOULOS, Constantin; WO2015/48245; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-64-3, 3,6-Dichloro-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 20 ml microwave flask 3,6-dichloro-4-methylpyridazine (2.30 g, 14.11 mmol) and a 7 M solution OfNH3 in methanol (10.08 ml, 70.6 mmol) were added and heated at 140 C for 4 h under microwave irradiation. After this time the dark brown solution was evaporated and columned on silica gel (flash master, DCM/MeOH form 100/0 to 80/20). Collected fractions gave (0.91 g, 6.33 mmol, 45%) of a 2/1 mixture of 6-chloro-5-methyl-3- pyridazinamine and 6-chloro-4-methyl-3-pyridazinamine. This material was recrystallized from EtOAc: from the first run 6-chloro-4-methyl-3-pyridazinamine (D4) (0.136 g, 0.95 mmol) was obtained. HPLC (walk-up): rt = 1.21 min. MS: (ES/+) m/z: 287 [dimer+1, 100%] and 289 [dimer+1, 66%]. C5H6ClN3 requires 144. UPLC: rt = 0.33, peak observed: 144 (M+ 1, 100%) and 146 (M+l, 33%). 1H NMR (400 MHz, DMSO-J6) delta ppm: 6.74 (s, 1 H) 6.47 (s, 2 H) 2.18 (s, 3 H). The mother liquors were taken and recrystallized with EtOAc other 3 times to give 6-chloro-5-methyl-3-pyridazinamine (0.136 g, 0.95 mmol). HPLC (walk-up): rt = 0.74 min. MS: (ES/+) m/z: 166 [M+Na, 100%] and 168 [M+Na, 33%]. C5H6ClN3 requires 144. UPLC: rt = 0.32, peak observed: 144 (M+l, 100%) and 146 (M+l, 33%). 1H NMR (400 MHz, DMSO-J6) delta ppm: 7.30 (s, 1 H) 6.44 (s, 2 H) 2.08 (s, 3 H).

19064-64-3, The synthetic route of 19064-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; ALVARO, Giuseppe; AMANTINI, David; BELVEDERE, Sandro; WO2010/60472; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-64-3, 3,6-Dichloro-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3,6-dichloro-4-methylpyridazine (5 g, 30.7 mmol) and concentrated NH40H solution (100 ml) was heated to 120 in a sealed autoclave for 18 hrs at 6 bar. The mixture was cooled to r.t, diluted with water (200 ml) and stirred in an ice bath for 2 hrs. The solid was collected by filtration, washed with water and dried. The filtrate was extracted with CH2Cl2/MeOH (9: 1). The organic was washed with brine, dried over MgSC^, filtered and evaporated. The precipitate from the reaction mixture and the solid isolated by extraction were combined. This crude product was purified by column chromatography using a CH2Cl2/MeOH gradient as eluent, to provide 6-chloro-4-methylpyridazin-3-amine (456 mg, 10%) and 6-chloro-5-methylpyridazin- 3-amine (350 mg, 8%>), both as off-white solids. MS: M = 144.1 (M+H)+ (both isomers)

19064-64-3, 19064-64-3 3,6-Dichloro-4-methylpyridazine 87923, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; LERNER, Christian; WO2014/72261; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-64-3, 3,6-Dichloro-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

19064-64-3, (1a) 3,6-Dichloro-4-methyl pyridizine (4.2 g, 26 mmol, Alfa) was suspended in aqueous 28% NH4OH (14 mL) in a sealed microwave tube and heated at 155 C. for 1.5 h. The microwave tube was uncapped and allowed to stir at room temperature for 30 min and in an ice bath for 30 min. The solid that crashed out was filtered, washed with ice water, and dried to give a mixture of 6-chloro-5-methylpyridazin-3-amine and 3-chloro-5-methylpyridazin-6-amine (3.4 g, 91%).

19064-64-3 3,6-Dichloro-4-methylpyridazine 87923, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; US2007/78136; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem