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INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE

The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N203 – PubChem

 

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Imidazo-ring-like PAR4 antagonists and medical uses thereof (by machine translation)

The compounds of the present (I) invention can (II) be used in the preparation of a, medicament for the prophylaxis or treatment of thromboembolic disorders, or. a pharmaceutically acceptable salt or ester or solvate thereof according to the present invention or. a pharmaceutically acceptable salt or ester or solvate thereof. (by machine translation)

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N227 – PubChem

 

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SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES

The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I) in which X, Y, R1, R2, R3 and R4 are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, repectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.

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Reference:
Pyridazine – Wikipedia,
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The present invention relates to a compound of the following formula (I), or a salt, solvate, tautomer, enantiomer, diastereoisomer or racemic mixture thereof: as well as its use as a drug, notably in the treatment of hepatitis C, its preparation process, and the pharmaceutical compositions containing such a compound.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N215 – PubChem

 

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CONDENSED PYRIMIDINE OR PYRIDAZINE DERIVATIVES AS ANTIVIRAL AGENTS

A compound of formula (I) or a pharmaceutically acceptable salt thereof. The compound is a prodrug of a PI4KIIIbetainhibitor and as such is useful as an antiviral agent. A pharmaceutical composition comprising the compound.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N229 – PubChem

 

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IMIDAZOPYRIDAZINE COMPOUNDS

The present invention relates to novel substituted imidazo[1,2-b] pyridazine compounds of Formula (I) pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.

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Pyridazine – Wikipedia,
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PAR4 AGONIST PEPTIDES

The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N220 – PubChem

 

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AN NMR INVESTIGATION OF THE GEOMETRICAL ISOMERISM IN THE ANIONS AMINO COMPOUNDS

The nmr spectra of the anions of 2-, 6- and 8-aminopurines, 2- and 4-aminopyrimidines, 3- and 4-aminopyridazines, aminopyrazine, 2-aminopyridine, aniline and its p-methyl derivative in liquid ammonia containing potassium amide at low temperature show the presence of two geometrical isomers, due to restricted rotation of the deprotonated amino group.The occurrence of coalescence has been observed with aminopyrazine and p-methylaniline.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N238 – PubChem

 

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Highly efficient one-pot synthesis of fused pyrimidones from 2-heteroaryl amines and Morita?Baylis?Hillman carbonates via intermolecular cyclocondensation

A highly selective and efficient cyclocondensation reaction for construction of various 3-substituted-2H-pyrido[1,2-a]pyrimidin-2-ones and related fused pyrimidones from allylic carbonates and 2-heteroaryl amines has been developed. The transformation involves one-pot sequential aza-Michael addition, intramolecular acyl substitution, and [1,3]-H shift. The method is catalyst free, eco-friendly, scalable, and completes within a short reaction time, with no work-up, no column purification, and demonstrate a broad functional group tolerance.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N237 – PubChem

 

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PYRENE DERIVATIVES AND ORGANIC ELECTRO LUMINESCENT DEVICE COMPRISING SAME

Is [: The pyrene derivative compound according to the present invention is represented by the following A] through [and B], and the pyrene derivative according to the present invention has a significantly improved blue color purity as compared to an organic electroluminescent device employing the pyrene derivative compound of Formula, and thus can be used as a variety of display devices, having excellent lifetime characteristics . luminance characteristics. [: A] [(Chem. B]). (by machine translation)

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Pyridazine – Wikipedia,
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