Category: 17739-45-6

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17739-45-6, is researched, SMILESS is BrCCOC1CCCCO1, Molecular C7H13BrO2Journal, Article, International Journal of Systematic and Evolutionary Microbiology called Pontimicrobium aquaticum gen. nov., sp. nov., a bacterium in the family Flavobacteriaceae isolated from seawater, Author is Janthra, Thidarat; Baek, Jihye; Kim, Jong-Hwa; Yoon, Jung-Hoon; Sukhoom, Ampaitip; Kim, Wonyong, the main research direction is Pontimicrobium bacteria Flavobacteriaceae seawater; Flavobacteriaceae; Pontimicrobium aquaticum; seawater.Category: pyridazine.

A Gram-stain-neg., yellow-pigmented, non-spore-forming, non-motile, rod-shaped, catalase-pos., strictly aerobic bacterial strain, designated CAU 1491T, was isolated from seawater and its taxonomic position was examined using a polyphasic approach. Cells of strain CAU 1491T grew optimally at 30°C, pH 7.5 and in 2.0% (w/v) NaCl. Phylogenetic anal. based on the 16S rRNA gene sequence of CAU 1491T showed that it formed a distinct lineage within the family Flavobacteriaceae as a sep. deep branch, with 97.0% or lower sequence similarity to representatives of the genera Lacinutrix, Gaetbulibacter and Aquibacter. The major cellular fatty acids of strain CAU 1491T were iso-C15:0, iso-C15:1 G, iso-C17:0 3-OH and summed feature 3. The polar lipid pattern consisted of diphosphatidylglycerol, phosphatidylserine, phosphatidylethanolamine and an unidentified phospholipid. The strain contained MK-6 as the sole respiratory quinone. Genome sequencing revealed that strain CAU 1491T has a genome size of 3.13 Mbp and a G + C content of 32.4 mol%. On the basis of the phenotypic, chemotaxonomic and genomic data, strain CAU 1491T represents a new genus and species in the family Flavobacteriaceae for which the name Pontimicrobium aquaticum gen. nov., sp. nov. is proposed. The type strain of Pontimicrobium aquaticum is CAU 1491T (= KCTC 72003T = NBRC 113695T).

As far as I know, this compound(17739-45-6)Category: pyridazine can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Wang, Tao; Su, Xiaoge; Zhang, Xuepeng; Huang, Wenhuan; Huang, Linkun; Zhang, Xingyuan; Sun, Xiang; Luo, Yi; Zhang, Guoqing published an article about the compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran( cas:17739-45-6,SMILESS:BrCCOC1CCCCO1 ).Category: pyridazine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:17739-45-6) through the article.

Room-temperature phosphorescent (RTP) materials have been widely used in sensing, imaging and display technol. The ability to predict and modulate RTP properties, such as emission color and lifetime, is particularly important for the design of rational materials. Here, we show that by incorporating three different types of acceptor moieties into a polylactide (PLA)-substituted carbazole donor, RTP with different emission colors and lifetimes (with an absolute quantum yield of up to 39.4%) could be generated. Specifically, the chem. conjugation between an n-π* type of luminophore and a π-π* one most likely results in dual RTP while the conjugation between two π-π* types of luminophores produces fluorescence-RTP (F-RTP) dual emission. The consistency between the exptl. results and theor. calculations further validates the observation. To demonstrate the versatility and application potential of these purely organic, biocompatible materials, aqueous nanoparticles were fabricated and used as high-contrast cell imaging agents, given the large Stokes shift of RTP materials.

As far as I know, this compound(17739-45-6)Category: pyridazine can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

HPLC of Formula: 17739-45-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about Development of high-affinity fluorinated ligands for cannabinoid subtype 2 receptor, and in vitro evaluation of a radioactive tracer for imaging. Author is Modemann, Daniel J.; Mahardhika, Andhika B.; Yamoune, Sabrina; Kreyenschmidt, Anne-Katrin; Maass, Frederike; Kremers, Sarah; Breunig, Christian; Sahlmann, Carsten-Oliver; Bucerius, Jan; Stalke, Dietmar; Wiltfang, Jens; Bouter, Yvonne; Mueller, Christa E.; Bouter, Caroline; Meller, Birgit.

The development of neurodegenerative diseases is associated with cerebral inflammation, which activates resident immune cells of the central nervous system (CNS), namely microglial cells that show an up-regulation of the cannabinoid subtype 2 receptor (CB2R) expression. Therefore our work aimed to design and synthesize a radiotracer for the detection of CB2R expression by positron emission tomog. (PET) allowing an early diagnosis of neurodegenerative diseases. For the development of such a PET tracer, N-alkyl-substituted indole-3-yl-tetramethylcyclopropylketones served as lead structures due to their high CB2R potency and selectivity, allowing radiolabeling on the N-alkyl chain. To this end, eight novel fluorinated N-alkyl-indole-3-yl-tetramethylcyclopropylketones were synthesized, investigated in radioligand binding studies, and structure-activity relationships were evaluated. The most promising candidate was (1-(4-fluoropropyl)-1H-indole-3-yl)(2,2,3,3-tetramethyl-cyclopropyl)methanone (Ki: 7.88 nM at the CB2R, 3430 nM at cannabinoid subtype 1 receptor (CB1R)). A precursor was synthesized, radiofluorinated with no-carrier-added [18F]F- by nucleophilic substitution of a tosyl group, and the resulting PET ligand was purified, all being performed on a fully automated synthesis module. The tracer was produced in 34 ± 6% radiochem. yield within 2 h and with molar activities of up to 1500 GBq/μmol. A first preclin. evaluation was carried out including determination of logP, metabolic stability by liver microsomes, and autoradiog. The novel PET tracer for imaging CB2R showed promising results warranting subsequent clin. evaluation.

In addition to the literature in the link below, there is a lot of literature about this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran)HPLC of Formula: 17739-45-6, illustrating the importance and wide applicability of this compound(17739-45-6).

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Quality Control of 2-(2-Bromoethoxy)tetrahydro-2H-pyran. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about Pontimicrobium aquaticum gen. nov., sp. nov., a bacterium in the family Flavobacteriaceae isolated from seawater. Author is Janthra, Thidarat; Baek, Jihye; Kim, Jong-Hwa; Yoon, Jung-Hoon; Sukhoom, Ampaitip; Kim, Wonyong.

A Gram-stain-neg., yellow-pigmented, non-spore-forming, non-motile, rod-shaped, catalase-pos., strictly aerobic bacterial strain, designated CAU 1491T, was isolated from seawater and its taxonomic position was examined using a polyphasic approach. Cells of strain CAU 1491T grew optimally at 30°C, pH 7.5 and in 2.0% (w/v) NaCl. Phylogenetic anal. based on the 16S rRNA gene sequence of CAU 1491T showed that it formed a distinct lineage within the family Flavobacteriaceae as a sep. deep branch, with 97.0% or lower sequence similarity to representatives of the genera Lacinutrix, Gaetbulibacter and Aquibacter. The major cellular fatty acids of strain CAU 1491T were iso-C15:0, iso-C15:1 G, iso-C17:0 3-OH and summed feature 3. The polar lipid pattern consisted of diphosphatidylglycerol, phosphatidylserine, phosphatidylethanolamine and an unidentified phospholipid. The strain contained MK-6 as the sole respiratory quinone. Genome sequencing revealed that strain CAU 1491T has a genome size of 3.13 Mbp and a G + C content of 32.4 mol%. On the basis of the phenotypic, chemotaxonomic and genomic data, strain CAU 1491T represents a new genus and species in the family Flavobacteriaceae for which the name Pontimicrobium aquaticum gen. nov., sp. nov. is proposed. The type strain of Pontimicrobium aquaticum is CAU 1491T (= KCTC 72003T = NBRC 113695T).

In addition to the literature in the link below, there is a lot of literature about this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran)Quality Control of 2-(2-Bromoethoxy)tetrahydro-2H-pyran, illustrating the importance and wide applicability of this compound(17739-45-6).

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Tear, Louise R.; Carrera, Carla; Gianolio, Eliana; Aime, Silvio published the article 《Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues》. Keywords: MRI contrast agent relaxometry gadolinium HPDO3A analog; MRI contrast agents; gadolinium; lanthanides; macrocycles; relaxometry.They researched the compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran( cas:17739-45-6 ).Related Products of 17739-45-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17739-45-6) here.

The properties of LnIII-HPDO3A complexes as relaxation enhancers and paraCEST agents are essentially related to the hydroxylpropyl moiety. A series of three HPDO3A derivatives, with small modifications to the hydroxyl arm, were herein studied to understand how heightened control can be gained over the parameters involved in the design of these agents. A full 1H and 17O-NMR relaxometric anal. was conducted and demonstrated that increasing the length of the OH group from the lanthanide center significantly enhanced the water exchange rate of the gadolinium complex, but with a subsequent reduction in kinetic stability. Alternatively, the introduction of an addnl. Me group, which increased the steric bulk around the OH moiety, gave almost exclusively the TSAP isomer (95 %) as identified by 1H-NMR of the europium complex. The gadolinium analog of this complex also exhibited a very fast water exchange rate, but with no detectable loss of kinetic stability. This complex therefore demonstrates a notable improvement over Gd-HPDO3A.

In addition to the literature in the link below, there is a lot of literature about this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran)Related Products of 17739-45-6, illustrating the importance and wide applicability of this compound(17739-45-6).

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Related Products of 17739-45-6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about A combinatory approach towards the design of organic polymer luminescent materials. Author is Wang, Tao; Su, Xiaoge; Zhang, Xuepeng; Huang, Wenhuan; Huang, Linkun; Zhang, Xingyuan; Sun, Xiang; Luo, Yi; Zhang, Guoqing.

Room-temperature phosphorescent (RTP) materials have been widely used in sensing, imaging and display technol. The ability to predict and modulate RTP properties, such as emission color and lifetime, is particularly important for the design of rational materials. Here, we show that by incorporating three different types of acceptor moieties into a polylactide (PLA)-substituted carbazole donor, RTP with different emission colors and lifetimes (with an absolute quantum yield of up to 39.4%) could be generated. Specifically, the chem. conjugation between an n-π* type of luminophore and a π-π* one most likely results in dual RTP while the conjugation between two π-π* types of luminophores produces fluorescence-RTP (F-RTP) dual emission. The consistency between the exptl. results and theor. calculations further validates the observation. To demonstrate the versatility and application potential of these purely organic, biocompatible materials, aqueous nanoparticles were fabricated and used as high-contrast cell imaging agents, given the large Stokes shift of RTP materials.

In addition to the literature in the link below, there is a lot of literature about this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran)Related Products of 17739-45-6, illustrating the importance and wide applicability of this compound(17739-45-6).

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about Tuning the Mechanical Properties of a Polymer Semiconductor by Modulating Hydrogen Bonding Interactions, the main research direction is tuning polymer semiconductor modulating hydrogen bonding.Synthetic Route of C7H13BrO2.

Conjugation breakers (CBs) with different H-bonding chemistries and linker flexibilities are designed and incorporated into a diketopyrrolopyrrole (DPP)-based conjugated polymer backbone. The effects of H-bonding interactions on polymer semiconductor morphol., mech. properties, and elec. performance are systematically investigated. We observe that CBs with an H-bonding self-association constant >0.7 or a denser packing tendency are able to induce higher polymer chain aggregation and crystallinity in as-casted thin films, resulting in a higher modulus and crack on-set strain. Addnl., the rDoC (relative degree of crystallinity) of the stretched thin film with the highest crack on-set strain only suffers a small decrease, suggesting the main energy dissipation mechanism is the breakage of H-bonding interactions. By contrast, other less stretchable polymer films dissipate strain energy through the breakage of crystalline domains, indicated by a drastic decrease in rDoC. Furthermore, we evaluate their elec. performances under mech. strain in fully stretchable field-effect transistors. The polymer with the highest crack on-set strain has the least degradation in mobility as a function of strain. Overall, these observations suggest that we can aptly tune the mech. properties of a polymer semiconductor by modulating intermol. interactions, such as H-bonding chem. and linker flexibility. Such understanding provides mol. design guidelines for future stretchable semiconductors.

In addition to the literature in the link below, there is a lot of literature about this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran)Synthetic Route of C7H13BrO2, illustrating the importance and wide applicability of this compound(17739-45-6).

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Electric Literature of C7H13BrO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about Synthesis and preclinical evaluation of [18F]PF04217903, a selective MET PET tracer. Author is Lien, Vegard Torp; Hauge, Emily; Nuruddin, Syed; Klaveness, Jo; Olberg, Dag Erlend.

The tyrosine kinase MET (hepatocyte growth factor receptor) is abnormally activated in a wide range of cancers and is often correlated with a poor prognosis. Precision medicine with positron emission tomog. (PET) can potentially aid in the assessment of tumor biochem. and heterogeneity, which can prompt the selection of the most effective therapeutic regimes. The selective MET inhibitor PF04217903 (1) formed the basis for a bioisosteric replacement to the deoxyfluorinated analog [18F]2, intended as a PET tracer for MET. [18F]2 could be synthesized with a “”hydrous fluoroethylation”” protocol in 6.3 ± 2.6% radiochem. yield and a molar activity of >50 GBq/μmol. In vitro autoradiog. indicated that [18F]2 specifically binds to MET in PC3 tumor tissue, and in vivo biodistribution in mice showed predominantly a hepatobiliary excretion along with a low retention of radiotracer in other organs.

There are many compounds similar to this compound(17739-45-6)Electric Literature of C7H13BrO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about New GSH-responsive amphiphilic zinc(II) phthalocyanine micelles as efficient drug carriers for combinatorial cancer therapy.Computed Properties of C7H13BrO2.

Combination therapies for the treatment of cancer have attracted wide attention. The poor selectivity and biocompatibility of photosensitizers (PS) limit the use of combination therapies in chemotherapy and photodynamic therapy (PDT) for cancer. In this work, the Gender PS (mPEG-b-PLA-S-S-ZnPC), asym. zinc(II) phthalocyanine (ZnPC) and mono-methoxy oxygen-based polyethylene glycol-polylactic acid (mPEG-b-PLA) were designed and synthesized for PDT through disulfide bond (-S-S-). The amphipathic PS could be self-assembled into a micelle in aqueous solution, and paclitaxel (PTX) was encapsulated in the core of the micelle for chemotherapy (PTX/mPEG-b-PLA-S-S-ZnPc). The PTX/mPEG-b-PLA-S-S-ZnPc micelle was spherical with a uniform diameter of about 184 nm. At the first 48 h, the release behaviors of ZnPC and PTX at 10 mmol / L GSH were 30% and 75.2%, resp. These results suggested that GSH-responsive PTX/mPEG-b-PLA-S-S-ZnPc micelle was an active ingredient in combination therapies for cancer.

There are many compounds similar to this compound(17739-45-6)Computed Properties of C7H13BrO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about Novel 18F-Labeled Isonicotinamide-Based Radioligands for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3β, the main research direction is fluorine 18 isonicotinamide radioligand preparation PET imaging GSK3 brain; 18F-labeled; GSK-3β; PET; brain; isonicotinamide.SDS of cas: 17739-45-6.

Glycogen synthase kinase-3β (GSK-3β), a cytoplasmic serine/threonine protein kinase, is involved in several human pathologies including Alzheimer’s disease, bipolar disorder, diabetes, and cancer. Positron emission tomog. (PET) imaging of GSK-3β could aid in investigating GSK-3β levels under normal and pathol. conditions. In this study, we designed and synthesized fluorinated PET radioligands starting with recently identified isonicotinamide derivatives that showed potent affinity to GSK-3β. After extensive in vitro inhibitory activity assays and analyzing U87 cell uptake, we identified [18F]10a-d as potential tracers with good specificity and high affinity. They were then subjected to further in vivo evaluation in rodent brain comprising PET imaging and metabolism studies. The radioligands [18F]10b-d penetrated the blood-brain barrier and accumulated in GSK-3β-rich regions, including amygdala, cerebellum, and hippocampus. Also, it could be specifically blocked using the corresponding standard compounds With these results, this work sets the basis for further development of novel 18F-labeled GSK-3β PET probes.

There are many compounds similar to this compound(17739-45-6)SDS of cas: 17739-45-6. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem