Category: 17645-17-9

17645-17-9, Name is 6-Chloro-N3-methylpyridazine-3,4-diamine, belongs to pyridazine compound, is a common compound. Formula: C5H7ClN4In an article, once mentioned the new application about 17645-17-9.

A process is described for the production of cyclohexanedimethanol by hydrogenation of a dialkyl cyclohexanedicarboxylate which comprises: (a) providing a hydrogenation zone containing a charge of a granular heterogeneous ester hydrogenation catalyst; (b) forming a vaporous feed stream of a hydrogen-containing gas,and a hydrogenatable material comprising a dialkyl cyclohexanedicarboxylate at a feed temperature which is in the range of from about 150 C. to about 350 C. and which is above the dew point of the feed stream and at a feed pressure in the range of from about 150 psia (about 10.34 bar) to about 2000 psia (about 137.90 bar), said vaporous feed stream having a known hydrogen-containing gas:dialkyl cyclohexanedicarboxylate ratio; (c) supplying the vaporous feed stream to the hydrogenation zone; (d) maintaining hydrogenation conditions in the hydrogenation zone which are effective to maintain the reaction mixture in contact with the hydrogenation catalyst above its dew point; (e) passing the vaporous feed stream through the hydrogenation zone; and (f) recovering from the hydrogenation zone a product stream containing cyclohexanedimethanol. In this process it is preferred to use dimethyl 1,4-cyclohexanedicarboxylate to produce 1,4-cyclohexanedimethanol.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 17645-17-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2087 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C5H7ClN4, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 17645-17-9

A process is described for the production of cyclohexanedimethanol by hydrogenation of a dialkyl cyclohexanedicarboxylate which comprises the steps of: (a) providing a hydrogenation zone containing a charge of a granular reduced manganese promoted copper catalyst; (b) forming a vaporous feed stream of a hydrogenatable material comprising a dialkyl cyclohexanedicarboxylate and from about 0.1 wt % up to about 15 wt % of an acidic material at a feed temperature which is in the range of from about 150 C. to about 350 C. and which is above the dew point of the feed stream and at a feed pressure which is in the range of from about 150 psia (about 10.34 bar) up to about 2000 psia (about 137.90 bar), said vaporous mixture having a known hydrogen-containing gas:dialkyl cyclohexanedicarboxylate ratio; (c) supplying the vaporous feed stream to the hydrogenation zone; (d) maintaining hydrogenation conditions in the hydrogenation zone which are effective to maintain the reaction mixture in contact with the catalyst above its dew point; (e) passing the vaporous feed stream through the hydrogenation zone: and (f) recovering from the hydrogenation zone a product stream comprising cyclohexanedimethanol.

If you are interested in 17645-17-9, you can contact me at any time and look forward to more communication. COA of Formula: C5H7ClN4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2083 – PubChem

 

Electric Literature of 17645-17-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.17645-17-9, Name is 6-Chloro-N3-methylpyridazine-3,4-diamine, molecular formula is C5H7ClN4. In a Article，once mentioned of 17645-17-9

A site-selective catalytic incorporation of multiple CO2 molecules into 1,3-dienes en route to adipic acids is described. This protocol is characterized by its mild conditions, excellent chemo- and regioselectivity and ease of execution under CO2 (1 atm), including the use of bulk butadiene and/or isoprene feedstocks.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 17645-17-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2094 – PubChem

 

Synthetic Route of 17645-17-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 17645-17-9, 6-Chloro-N3-methylpyridazine-3,4-diamine, introducing its new discovery.

A continuous process is described for the production of 1,4-cyclohexanedimethanol (CHDM) having a desired or predetermined trans-:cis- isomer ratio by catalytic hydrogenation of a dialkyl 1,4-cyclohexanedicarboxylate in the presence of an ester hydrogenation catalyst. The process is capable of being operated for an extended period of time during which the hydrogenation catalyst declines in catalytic activity and comprises feeding a vaporous mixture of the dialkyl 1,4-cyclohexanedicarboxylate and hydrogen to a hydrogenation zone containing the hydrogenation catalyst and recovering CHDM product. The degree of conversion of the dialkyl 1,4-cyclohexanedicarboxylate at a particular combination of temperature and pressure is related to the trans-:cis- isomer ratio of the CHDM product and may be varied by adjusting at least one feed condition selected from (i) the dialkyl 1,4-cyclohexanedicarboxylate feed rate and (ii) the hydrogen-containing gas:dialkyl 1,4-cyclohexanedicarboxylate molar ratio. As catalyst activity declines during operation of the process over an extended period of time at a particular combination of temperature and pressure, the degree of conversion of the dialkyl 1,4-cyclohexanedicarboxylate and/or the trans-:cis- isomer ratio of the CHDM product may be maintained at a constant value by adjusting at least one of the feed conditions referred to above. The determination of the Actual Activity and Reference Activity of the catalyst and the Actual and Effective Residence Times are included in the hydrogenation process.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 17645-17-9. In my other articles, you can also check out more blogs about 17645-17-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2086 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Computed Properties of C5H7ClN4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 17645-17-9, Name is 6-Chloro-N3-methylpyridazine-3,4-diamine, molecular formula is C5H7ClN4

Ruthenium nanoparticles supported onto aluminum-doped mesoporous silica catalysts (Ru/Al-SBA-15) are fabricated using hydrothermal and impregnation methods for catalysis application. The Ru/Al-SBA-15-3 catalyst at a Si/Al molar ratio of 3 exhibited excellent catalytic performance for the hydrogenation of p-phthalic acid with high conversion efficiency (100.0%) and cis-isomer selectivity (84.0%) in water. Moreover, this system displays exceptional stability and recyclability through preserving the conversion efficiency, as well as a cis-isomer selectivity of 90.2 and 83.3%, respectively, after reusing it fourteen times. Such an exceptional system can also be ideal for the hydrogenation of aromatic dicarboxylic acids and their ester derivatives in water. Strong Lewis acid sites due to doped Al species play significant roles in the hydrogenation reaction. Moreover, isotope labeling studies indicated that water molecules effectively participated in the hydrogenation reaction. Hydrogen and water contributed half of the hydrogen atoms for this hydrogenation reaction. In the end, a plausible mechanistic pathway for the hydrogenation of p-phthalic acid using the Ru/Al-SBA-15-3 catalyst in water is proposed.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C5H7ClN4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 17645-17-9, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2089 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 17645-17-9, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 17645-17-9, Name is 6-Chloro-N3-methylpyridazine-3,4-diamine, molecular formula is C5H7ClN4

Starting from 7-oxobicyclo<2.2.1>heptane-1-carbonyl chloride (3), bicyclo<2.2.0>hexane-1-carboxylic acid (9) was prepared via Hunsdiecker degradation and Favorskii rearrangement.The conversion of 9 to 1-methoxybicyclo<2.2.0>hexane (15) via methyl ketone 12 and acetate 13 was complicated by the facile homoketonization of the elusive bicyclo<2.2.0>hexane-1-ol (14).Similarly, bicyclo<2.2.0>hexane-1-amine readily underwent hydrolysis whereas N,N-dimethylbicyclo<2.2.0>hexane-1-amine (17) proved to be more resistant.Thermolysis of methyl bicyclo<2.2.0>hexane-1-carboxylate (10) revealed a “normal” rate enhancement (DeltaEa ca. 6 kcal/mol = 25 kJ/mol).The effects of 1-acetoxy, 1-methoxy and 1-dimethylamino groups on the rate of rearrangement were unexpectedly small.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 17645-17-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 17645-17-9, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2092 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C5H7ClN4, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 17645-17-9

Dimethyl and diethyl esters of cis-cyclohexane- 1,2- 1,3-, and 1,4-dicarboxylic acids cis-1, cis-2, and cis-3 give rise to major MH+ ions under ammonia chemical ionization (NH3-CI) conditions (minor [M + NH4]+) and to abundant [MH – ROH]+ ions under isobutane chemical ionization (i-Bu-CI) and collision induced dissociation (CID) conditions, indicating interaction between the two adjacent ester groups (stabilization of MH+ ion by hydrogen bridging and facilitating the ROH elimination by proton transfer between the two alkoxycarbonyl groups). Cyclohexane-trans-1,2-dicarboxylates trans-1 exhibit a similar interaction giving rise to major MH+ ions under NH3-CI and to abundant [MH – ROH]+ ions upon i-Bu-CI and CID. trans-1,4-Bis(alkoxycarbonyl)cyclohexanes trans-3, in which the two remote alkoxycarbonyl groups cannot interact, give rise to major [M + NH4]+ions under NH3-CI (minor MH+) and to negligible [MH – ROH]+ ions under i-Bu-CI and CID. trans-1,3-Diesters trans-2 behave in an unexpected way: They exhibit not only major [M + NH4]+ and minor MH+ ions under NH3-CI, in consistency with the large distance between the two ester groups, but also abundant [MH – ROH]+ ions under i-Bu-CI and upon CID conditions, indicating occurrence of a proton migration between the two alkoxycarbonyl groups. This behavior is explained in terms of a strained transition state or intermediate involved in the ROH elimination from MH+ of the trans-1,3-diesters. Methyl substituents at the two alpha-positions 1 and 3 increase the barrier for the proton transfer resulting in suppression of the ROH elimination from the MH+ ions of trans-1,3-dimethyl-1,3-bis(carboalkoxy)cyclohexanes trans-4 under i-Bu-CI and CID conditions.

If you are interested in 17645-17-9, you can contact me at any time and look forward to more communication. HPLC of Formula: C5H7ClN4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2090 – PubChem

 

Synthetic Route of 17645-17-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 17645-17-9, Name is 6-Chloro-N3-methylpyridazine-3,4-diamine, molecular formula is C5H7ClN4. In a Patent，once mentioned of 17645-17-9

A process is described for the production of cyclohexanedimethanol having a trans-:cis-isomer ratio greater than about 1:1 by hydrogenation of a dialkyl (e.g. dimethyl) cyclohexanedicarboxylate having a trans-:cis-isomer ratio less than about 1:1 which comprises: (a) providing a hydrogenation zone containing a charge of a granular heterogeneous ester hydrogenation catalyst; (b) supplying to the hydrogenation zone a vaporous feed stream containing hydrogen and a hydrogenarable material comprising a dialkyl cyclohexanedicarboxylate at an inlet temperature which is above its dew point of the mixture; (c) maintaining the hydrogenation zone under temperature and pressure conditions which are conducive to effecting hydrogenation of esters; (d) passing the vaporous feed stream through the hydrogenation zone; and (e) recovering from the hydrogenation zone a product stream containing cyclohexanedimethanol having a trans-:cis-isomer ratio greater than 1:1. In this process it is preferred to use dimethyl 1,4-cyclohexanedicarboxylate to produce 1,4-cyclohexanedimethanol.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 17645-17-9. In my other articles, you can also check out more blogs about 17645-17-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2088 – PubChem

 

Reference of 17645-17-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 17645-17-9, 6-Chloro-N3-methylpyridazine-3,4-diamine, introducing its new discovery.

Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation

A novel potent NMDA-NR2B selective antagonist (5b) without the reactive metabolites formation issue was identified. Through this study, a close correlation between reactive metabolites formation and calculated HOMO energies of parent compounds was found.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 17645-17-9. In my other articles, you can also check out more blogs about 17645-17-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2091 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 17645-17-9, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 17645-17-9, Name is 6-Chloro-N3-methylpyridazine-3,4-diamine, molecular formula is C5H7ClN4

A anti– 1, 4 – cyclohexane dicarboxylic acid mono methyl ester preparation method (by machine translation)

The present invention discloses an anti– 1, 4 – cyclohexane dicarboxylic acid mono methyl ester preparation method, in order to in the organic solvent has good solvent resistance of the mixing of the trans 1, 4 – cyclohexane dicarboxylic acid dimethyl as raw materials, the organic base catalyst of the isomerization reaction under the catalysis, then in the inorganic alkali under the action of the high selectivity of the monoester hydrolyzed to obtain the anti– 1, 4 – cyclohexane dicarboxylic acid mono methyl ester. Compared with the prior art has the following advantages: (1) the raw materials used in the organic solvent in the methanol has good solubility; (2) optimization of catalyst, reduces the activation energy of the isomerization reaction, the isomerization time is shortened, reducing energy consumption of reaction and cost, and is applicable to industrial production; (3) effectively reduces the diester hydrolysis, thereby reducing the acid by-product is 2% the following, improve the product purity; (4) a small amount of unreacted raw materials through the extracting process into the organic phase, to realize high-efficient separation of the product, to further improve the purity of the product. (by machine translation)

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, SDS of cas: 17645-17-9, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 17645-17-9

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2084 – PubChem