Category: 16082-13-6

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Formula: C10H12N2O4. Introducing a new discovery about 16082-13-6, Name is Diethyl pyridazine-3,4-dicarboxylate

A convenient route to prepare unsubstituted pyridazine-3,4-dicarboxylic acid on a preparative scale is described.The synthesis involves a hetero Diels-Alder reaction between a new 1,2-diaza-1,3-diene and ethyl vinyl ether and oxidation of the intermediate 1,4,5,6-tetrahydropyridazine as the key step.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C10H12N2O4, you can also check out more blogs about16082-13-6

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3007 – PubChem

 

Electric Literature of 16082-13-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16082-13-6, Name is Diethyl pyridazine-3,4-dicarboxylate, molecular formula is C10H12N2O4. In a Article£¬once mentioned of 16082-13-6

Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase

Human immunodeficiency virus type-1 integrase is an essential enzyme for effective viral replication and hence a valid target for the design of inhibitors. We report here on the design and synthesis of a novel series of phthalimide analogues as integrase inhibitors. The short synthetic pathway enabled us to synthesize a series of analogues with a defined structure diversity. The presence of a single carbonyl-hydroxy-aromatic nitrogen motif was shown to be essential for the enzymatic activity and this was confirmed by molecular docking studies. The enzymatically most active compound from this series is 7-(3,4-dichlorobenzyl)-5,9-dihydroxypyrrolo[3,4-g]quinoxaline-6,8- dione (15l) with an IC50 value of 112 nM on the HIV-1 integrase enzyme, while ((7-(4-chlorobenzyl)-5,9-dihydroxy-pyirolo[3,4-g]quinoxaline-6,8- dione (15k)) showed an EC50 of 270 nM against HIV-1 in a cell-based assay.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 16082-13-6. In my other articles, you can also check out more blogs about 16082-13-6

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3006 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 16082-13-6, name is Diethyl pyridazine-3,4-dicarboxylate, introducing its new discovery. category: pyridazine

HIV INTEGRASE INHIBITORS

The present invention concerns the compounds having the formula (1), N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof wherein (a) or (b); A, together with the two carbons of the phenyl ring to which it is attached forms a monocyclic aryl or a monocyclic Het2 ; R1 is hydrogen, halo, nitro, cyano, sultam, sulltim, C3-7cycloalkyl, C(=O)-R5, S(=O)y-R6, OR 7, NR8R9, C(=NR8)-R5, optionally polysubstituted C1-6alkyl, optionally polysubstituted C2-6alkenyl or optionally polysubstituted C2-6alkynyl; R 2 is hydrogen, C3-7cycloalkyl, aryl, Het1, Het2, C(=O)-R5, S(=O)Y-R6 OR7, NR8R9, C=NR8)-R5, or optionally polysubstituted C1-6alkyl, optionally polysubstituted C2-6alkenyl or optionally polysubstituted C2-6alkynyl. It further relates to their use as HIV integrase inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with other anti-retroviral agents, and to their use in assays as reference compounds or as reagents.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 16082-13-6, and how the biochemistry of the body works.category: pyridazine

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3005 – PubChem