Category: 14959-32-1

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, Application In Synthesis of 3-Chloro-6-(methylamino)pyridazine, molecular formula is C5H6ClN3, introducing its new discovery. Application In Synthesis of 3-Chloro-6-(methylamino)pyridazine

2-arylbenzothiophene derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient. Since the 2-arylbenzothiophene derivatives of Formula 1 have a relatively high binding affinity for beta-amyloid, they can be used as diagnostic reagents for diagnosing Alzheimer’s disease at an early stage by non-invasive techniques when they are labeled with radioisotopes: wherein R1-R4, V, W, X, Y and Z are as defined in the Detailed Descript of the specification. Further, when the pharmaceutical composition containing the 2-arylbenzothiophene derivative binds with a low-molecular weight beta-amyloid peptide binding compound, generation of malignant high-molecular weight beta-amyloid deposits is minimized. Accordingly, the pharmaceutical composition can be used as a therapeutic agent of degenerative brain disease such as Alzheimer’s disease

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 3-Chloro-6-(methylamino)pyridazine. In my other articles, you can also check out more blogs about 14959-32-1

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1025 – PubChem

 

Reference of 14959-32-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.14959-32-1, Name is 3-Chloro-6-(methylamino)pyridazine, molecular formula is C5H6ClN3. In a Article，once mentioned of 14959-32-1

BACKGROUND: Optimization studies on compounds initially designed to be herbicides led to the discovery of a series of [6-(3-pyridyl)pyridazin-3-yl]amides exhibiting aphicidal properties. Systematic modifications of the amide moiety as well as the pyridine and pyridazine rings were carried out to determine if these changes could improve insecticidal potency. RESULTS: Structure?activity relationship (SAR) studies showed that changes to the pyridine and pyridazine rings generally resulted in a significant loss of insecticidal potency against green peach aphids [Myzus persicae (Sulzer)] and cotton aphids [(Aphis gossypii (Glover)]. However, replacement of the amide moiety with hydrazines, hydrazones, or hydrazides appeared to be tolerated, with small aliphatic substituents being especially potent. CONCLUSIONS: A series of aphicidal [6-(3-pyridyl)pyridazin-3-yl]amides were discovered as a result of random screening of compounds that were intially investigated as herbicides. Follow-up studies of the structure-activity relationship of these [6-(3-pyridyl)pyridazin-3-yl]amides showed that biosteric replacement of the amide moiety was widely tolerated suggesting that further opportunities for exploitation may exist for this new area of insecticidal chemistry. Insecticidal efficacy from the original hit, compound 1, to the efficacy of compound 14 produced greater than 10-fold potency improvement against Aphis gossypii and greater than 14-fold potency improvement against Myzus persicae.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1027 – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Recommanded Product: 3-Chloro-6-(methylamino)pyridazine. Introducing a new discovery about 14959-32-1, Name is 3-Chloro-6-(methylamino)pyridazine

Novel Delta1-pyrrolines of the formula (I) 1in which R1, R2, R3, m and Q have the meanings given in the description, a plurality of processes for preparing these substances and their use for controlling pests.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 3-Chloro-6-(methylamino)pyridazine, you can also check out more blogs about14959-32-1

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1024 – PubChem

 

Synthetic Route of 14959-32-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.14959-32-1, Name is 3-Chloro-6-(methylamino)pyridazine, molecular formula is C5H6ClN3. In a Article，once mentioned of 14959-32-1

On reacting the 3-aminopyridazines 1a,d,e with dimethyl acetylenedicarboxylate (DMAD), the pyrimido[1,2-b]pyridazin-2(2H)-ones 2e-g, whereas starting from 1f, the 4(4H)-ones 5a and 3b,d were prepared. In the 2(2H)-one series, the reactions of 2b with various amino compounds resulted in various types of products. The reaction of N-methylaminopyridazines 1g,h with DMAD led to the endo-N-substituted derivatives 8a,b, whereas 1h with diethyl ethoxymethylenemalonate (DEM) gave the exo-N-substituted compound 1k. The constitution of the compounds was proved by spectroscopic and chemical evidences.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14959-32-1

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1030 – PubChem

 

Synthetic Route of 14959-32-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.14959-32-1, Name is 3-Chloro-6-(methylamino)pyridazine, molecular formula is C5H6ClN3. In a Article，once mentioned of 14959-32-1

Nucleophilic displacement of halide by alkoxide in pyridazines, phthalazines, a thiazole and a thiadiazole is unexpectedly activated by acetamido anion substituents compared to neutral amido and amino substituents.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14959-32-1

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1029 – PubChem

 

14959-32-1, Name is 3-Chloro-6-(methylamino)pyridazine, belongs to pyridazine compound, is a common compound. Recommanded Product: 3-Chloro-6-(methylamino)pyridazineIn an article, once mentioned the new application about 14959-32-1.

2-ARYLBENZOTHIOPHENE DERIVATIVES OR PHARCEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARCEUTICAL COMPOSITION FOR THE DIAGNOSIS OR TREATMENT OF DEGENERATIVE BRAIN DISEASE CONTAINING THE SAME AS ACTIVE INGREDIENT

2-arylbenzothiophene derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient. Since the 2-arylbenzothiophene derivatives of Formula 1 have a relatively high binding affinity for beta-amyloid, they can be used as diagnostic reagents for diagnosing Alzheimer’s disease at an early stage by non-invasive techniques when they are labeled with radioisotopes: wherein R1-R4, V, W, X, Y and Z are as defined in the Detailed Descript of the specification. Further, when the pharmaceutical composition containing the 2-arylbenzothiophene derivative binds with a low-molecular weight beta-amyloid peptide binding compound, generation of malignant high-molecular weight beta-amyloid deposits is minimized. Accordingly, the pharmaceutical composition can be used as a therapeutic agent of degenerative brain disease such as Alzheimer’s disease

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1025 – PubChem

 

Related Products of 14959-32-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.14959-32-1, Name is 3-Chloro-6-(methylamino)pyridazine, molecular formula is C5H6ClN3. In a article，once mentioned of 14959-32-1

Synthesis and properties of mesoionic pyrimido[1,2 b]pyridazine 2,4 diones and mesoionic pyridazino[2,3 a] s triazine 2,4 diones: mesoionic analogs structurally related to fervenulin

Derivatives of two new and unusual classes of heterocycles, possessing structural similarities to the broad spectrum antibiotic fervenulin, were synthesized and examined for in vitro antimicrobial activity. Only three of 17 mesoionic pyrimido[1,2 b]pyridazine 2,4 diones exhibited evidence of antimicrobial activity while seven of eight mesoionic pyridazino[2,3 a]s triazine 2,4 diones were active against one or more microorganisms. Susceptibility toward attack by nucleophiles of both mesoionic pyridazino[2,3 a]s triazine 2,4 diones and fervenulin was observed.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14959-32-1

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1028 – PubChem

 

Reference of 14959-32-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 14959-32-1, 3-Chloro-6-(methylamino)pyridazine, introducing its new discovery.

HETEROARYLAMINOISOQUINOLINES, METHODS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF

The application is directed to compounds of formula (IA) : and specifically compounds of formula (I) and their salts and solvates, wherein R1, R11, R12, R13, R4, R5, n, A1, A2, and A3 are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of conditions associated with the alteration of the activity of beta-galactosidase, specially galactosidase beta-1 or GLB1, including GM1 gangliosidoses and Morquio syndrome, type B.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 14959-32-1. In my other articles, you can also check out more blogs about 14959-32-1

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1026 – PubChem