Category: 1445-56-3

In 1998,Molecules [Electronic Publication] included an article by Fulep, Gunther; Haider, Norbert. Synthetic Route of C5H2ClN3. The article was titled 《Synthesis and intramolecular [4+2] cycloaddition reactions of 4-pyridazinecarbonitriles with alkyne side chains》. The information in the text is summarized as follows:

Title compounds I (X = O, R = H, Me; X = NH, R = H) were prepared I underwent thermally induced intramol. Diels-Alder reactions with inverse electron demand, affording fused benzonitriles (II). Incorporation of a 1,2-phenylene unit into the side chain, as in III (X = O, NAc), resulted in a more favorable conformation of the dienophilic substructure and thus in a pronounced acceleration of the [4+2] cycloaddition reaction. In the experiment, the researchers used 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Synthetic Route of C5H2ClN3)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Synthetic Route of C5H2ClN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In 1977,Chemical & Pharmaceutical Bulletin included an article by Yanai, Mitsuji; Takeda, Shigeko; Mitsuoka, Tamao. Category: pyridazine. The article was titled 《Studies on heterocyclic compounds. XX. The reaction of 4-cyano-3,6-dichloropyridazine with amines》. The information in the text is summarized as follows:

4-Cyano-3,6-dichloropyridazine (I) was treated with primary amines in MeOH under mild conditions (stirring at 0-5°) to give the corresponding 5-amino derivatives II (R = NHCH2CH2OH, NH2, PhCH2NH, NHMe, etc.) resulting from nuclear amination. When I was treated with secondary amines, the corresponding 3- or 6-amino derivatives were obtained.3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Category: pyridazine) was used in this study.

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Haider, Norbert; Heinisch, Gottfried; Lassnigg, Doris published their research in Journal of Heterocyclic Chemistry on February 29 ,1988. The article was titled 《Pyridazines. XXXV. Preparation of some novel pyrimido[4,5-c]pyridazine derivatives from 3-(alkylamino)- and 3-(arylamino)-4-pyridazinecarboxamides》.Product Details of 1445-56-3 The article contains the following contents:

Pyrimido[4,5-c]pyridazinediones I (R = Ph, PhCH2; R1R2 = O), pyrimido[4,5-c]pyridazinones II (R = Ph, PhCH2; R3 = H, Me, Et), and dihydropyrimido[4,5-c]pyridazinones I (R = Ph, PhCH2, Me2CH; R1 = H, R2 = Ph, 3-pyridyl) were prepared from 3-chloro-4-pyridazinecarbonitrile III (R4 = Cl) via amino carbonitriles III (R4 = NHR) and amino carboxamides. In addition, III (R4 = NH2) was prepared from III (R4 = Cl), via the tetrazolo[1,5-b]pyridazine IV as the key intermediate.3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Product Details of 1445-56-3) was used in this study.

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Product Details of 1445-56-3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Siegrist, Romain; Pozzi, Davide; Jacob, Gael; Torrisi, Caterina; Colas, Kilian; Braibant, Bertrand; Mawet, Jacques; Pfeifer, Thomas; de Kanter, Ruben; Roch, Catherine; Kessler, Melanie; Corminboeuf, Olivier; Bezencon, Olivier published their research in Journal of Medicinal Chemistry on December 8 ,2016. The article was titled 《Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers》.Computed Properties of C5H2ClN3 The article contains the following contents:

Despite the availability of numerous antiepileptic drugs, 20-30% of epileptic patients are pharmacoresistant with seizures not appropriately controlled. Consequently, new strategies to address this unmet medical need are required. T-type calcium channels play a key role in neuronal excitability and burst firing and selective triple T-type calcium channel blockers could offer a new way to treat various CNS disorders, in particular epilepsy. Herein the authors describe the identification of new 1,4-benzodiazepines as brain penetrant and selective triple T-type calcium channel blockers. From racemic hit 4 ((±)-N,1-dibenzyl-3,5-cis-dimethyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxamide), optimization work led to the preparation of pyridodiazepine 31c with improved physicochem. properties, solubility and metabolic stability. The racemic mixture was separated by chiral preparative HPLC and the resulting lead compound (3R,5S)-31c ((3R,5S)-N,1-dibenzyld-3,5-dimethyl-1,2,3,5-tetrahydro-4,5-pyrido[3,4-e][1,4]diazepine-4-carboxamide) showed promising efficacy in the WAG/Rij-rat model of generalized non-convulsive absence-like epilepsy. In the experiment, the researchers used many compounds, for example, 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Computed Properties of C5H2ClN3)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Computed Properties of C5H2ClN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Dostal, Wolfgang; Heinisch, Gottfried; Loetsch, Gerhard published an article in Monatshefte fuer Chemie. The title of the article was 《Chemistry of pyridazines. XXXVI. Novel diaza-analogs of 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one》.Name: 3-Chloropyridazine-4-carbonitrile The author mentioned the following in the article:

Procedures for the preparation of the novel tricyclic ketones 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-d]pyridazin-5-one (I), 5,6-dihydro-11H-benzo[4,5]cyclohepta[2,1-c]pyridazin-11-one, and 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-c]pyridazin-5-one starting from a preformed 1,2-diazine system are proposed. The key intermediates, e.g., II (R = CO2Et) are prepared from (2-phenylethyl)pyridazines, e.g., II (R = H) by introduction of a carboxylic functionality via homolytic alkoxycarbonylation or via a sulfonyl Reissert-type reaction. The experimental process involved the reaction of 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Name: 3-Chloropyridazine-4-carbonitrile)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Name: 3-Chloropyridazine-4-carbonitrile

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Safety of 3-Chloropyridazine-4-carbonitrileOn May 31, 1991, Czech, Karin; Haider, Norbert; Heinisch, Gottfried published an article in Monatshefte fuer Chemie. The article was 《Pyridazines. LIV. The synthesis of pyridazine-fused S-heterocycles: thieno[2,3-c]pyridazine, pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine, and pyridazino[3,4-b][1,4]benzothiazine》. The article mentions the following:

Starting from 3-chloro-4-pyridazinecarbonitrile (I), the thienopyridazine derivatives II (R = OMe; R1 = OMe, NH2) were prepared Condensation of II (R = NH2) with (EtO3)CH afforded the novel tricyclic system III. Reaction of I (R = R1 = NH2) with 2-H2NC6H4SH, followed by treatment with NaH/DMSO gave pyridazinobenzothiazine IV instead of the expected condensed thiazepine. In the experiment, the researchers used many compounds, for example, 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Safety of 3-Chloropyridazine-4-carbonitrile)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Safety of 3-Chloropyridazine-4-carbonitrile

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

《Pyridazine analogs of biologically active compounds. VI. Pyrido[2,3-c]pyridazines structurally related to nalidixic acid》 was written by Boamah, Philip Y.; Haider, Norbert; Heinisch, Gottfried. Safety of 3-Chloropyridazine-4-carbonitrile And the article was included in Archiv der Pharmazie (Weinheim, Germany) on April 30 ,1990. The article conveys some information:

Synthesis of 8-alkyl-5,8-dihydro-5-oxopyrido[2,3-c]pyridazine-6-carboxylic acids I (R = Et, Pr, Me2CH, cyclopropyl) starting from 3-chloro-4-pyridazinecarbonitrile is reported. I do not exhibit significant (gyrase-inhibiting) antibacterial activity. In addition to this study using 3-Chloropyridazine-4-carbonitrile, there are many other studies that have used 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Safety of 3-Chloropyridazine-4-carbonitrile) was used in this study.

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Safety of 3-Chloropyridazine-4-carbonitrile

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Klempier, Norbert; De Raadt, Anna; Griengl, Herfried; Heinisch, Gottfried published their research in Journal of Heterocyclic Chemistry on February 29 ,1992. The article was titled 《Enzymic hydrolysis of heterocyclic nitriles》.Computed Properties of C5H2ClN3 The article contains the following contents:

Chemoselective hydrolysis of heterocyclic nitriles can be achieved by an easy to use immobilized biocatalyst prepared from Rhodococcus sp. Pyrimidine-2-carbonitrile and 3-chloropyridazine-4-carbonitrile were converted into the corresponding amides, while 2-ethoxycarbonyl-4-pyridinecarbonitrile, 6-methylpyridazine-3-carbonitrile, 3-chloropyridazine-4-carbonitrile, 3-ethoxycarbonyl-4,5-dihydroisoxazole-5-carbonitrile, indole-3-carbonitrile, and indole-3-acetonitrile were hydrolyzed to the acids. In addition to this study using 3-Chloropyridazine-4-carbonitrile, there are many other studies that have used 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Computed Properties of C5H2ClN3) was used in this study.

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Computed Properties of C5H2ClN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Haider, Norbert; Hochholdinger, Iris; Matyus, Peter; Wobus, Andrea published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Synthesis of ortho-functionalized 4-aminomethylpyridazines as substrate-like semicarbazide-sensitive amine oxidase inhibitors》.COA of Formula: C5H2ClN3 The author mentioned the following in the article:

A series of 4-aminomethylpyridazines and -pyridazin-3(2H)-ones (diaza-benzylamines), bearing alkylamino side chains in ortho position relative to the CH2NH2 unit, was synthesized by catalytic hydrogenation of nitriles in strongly acidic medium. N-Benzyl protecting groups either at the pyridazinone ring nitrogen or at an exocyclic nitrogen were selectively removed hydrogenolytically or by treatment with a Lewis acid. The new compounds were tested in vitro for semicarbazide-sensitive amine oxidase (SSAO) inhibitory activity and 4-(aminomethyl)-N,N’-diethylpyridazine-3,5-diamine was found to be the most active representative.3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3COA of Formula: C5H2ClN3) was used in this study.

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.COA of Formula: C5H2ClN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The author of 《Mesoionic pyridazine ribonucleosides. A novel biologically active nucleoside metabolite》 were Bambury, Ronald E.; Feeley, Daniel T.; Lawton, Gerald C.; Weaver, John M.; Wemple, James. And the article was published in Journal of Medicinal Chemistry in 1984. Formula: C5H2ClN3 The author mentioned the following in the article:

Ribofuranosylpyridazinium I was prepared from 4-cyano-3(2H)-pyridazinone (II) by using a low-temperature, kinetically controlled, silyl Hilbert-Johnson reaction followed by deblocking of the resulting triacetate derivative with NaHCO3 in MeOH. I is a urine metabolite of II in mice. I possesses Gram-neg. antibacterial activity in vivo against a systemic Escherichia coli infection in mice with an ED50 of 25-50 mg/kg. A series of 4-substituted 3-oxidopyridazinium ribonucleosides were synthesized as analogs of I. 4-Chloro-3-oxido-1-β-D-ribofuranoylpyridazinium was several times more active than I against E. coli in vitro although it showed no in vivo activity.3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Formula: C5H2ClN3) was used in this study.

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Formula: C5H2ClN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem