14305-08-9, 4,5-Dibromo-2-phenylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Similar reaction of 30 (1.005g, 3.05mmol, 1.00 equiv), glycinamide hydrochloride (0.70g, 6.31 mol, 2.07 equiv), and pyridine (0.51mL, 6.31mmol, 2.07 equiv) was heated under reflux in a mixture of EtOH (41mL) and DMF (5mL). After 48h starting material remained, so more glycinamide hydrochloride (2.98 equiv) and NEt3 (2.60mL, 18.65mmol, 6.12 equiv) were added and the mixture was heated under reflux for a further 16h. The cooled mixture was filtered through a pad of Celite and the filtrate was diluted with brine, extracted with CH2Cl2 (¡Á3) and the combined extracts were washed with brine, dried (MgSO4) and evaporated under reduced pressure. The residue was re-precipitated from MeOH: EtOAc to give 11 (77 mg, 8%) as an amorphous off-white solid: mp 216-219C; 1H NMR (CDCl3): delta 7.75 (s, 1H), 7.56 (br s, 1H), 7.47 (m, 4H), 7.39 (m, 1H), 7.24 (br s, 1H), 6.71 (m, 1H), 4.05 (d, J=6.20Hz, 2H); HRESIMS calcd for C12H1181BrN4NaO2 m/z [M+Na]+ 346.9938, found 346.9947, calcd for C12H1179BrN4NaO2 m/z [M+Na]+ 344.9958, found 344.9963; TLC Rf=0.22 (10% MeOH:EtOAc); HPLC purity: 98.7%., 14305-08-9
14305-08-9 4,5-Dibromo-2-phenylpyridazin-3(2H)-one 203396, apyridazine compound, is more and more widely used in various fields.
Reference£º
Article; Brooke, Darby G.; Van Dam, Ellen M.; Watts, Colin K.W.; Khoury, Amanda; Dziadek, Marie A.; Brooks, Hilary; Graham, Lisa-Jane K.; Flanagan, Jack U.; Denny, William A.; Bioorganic and Medicinal Chemistry; vol. 22; 3; (2014); p. 1029 – 1039;,
Pyridazine – Wikipedia
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